The relationship between uric acid to high-density lipoprotein cholesterol ratio and collateral index in patients with chronic total occlusion

Kardiologiia ◽  
2021 ◽  
Vol 61 (9) ◽  
pp. 61-65
Author(s):  
Cihan Aydın ◽  
Nadir Emlek
Keyword(s):  
Uric Acid ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Collateral Circulation ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Total Occlusion ◽  
Group 2 ◽  
Group 1

Background    High serum uric acid (UA) levels and low high-density lipoprotein cholesterol (HDL–C) levels are accepted as risk factors for cardiovascular mortality. Hyperuricemia and low HDL–C levels were associated with an increased risk of cardiovascular mortality and the development of diabetes and hypertension. However, the association of UA with cardiovascular (CV) mortality,collateral index are undetermined in patients with chronic total occlusion (CTO).Material and methods    124 patients who underwent coronary angiography with the diagnosis of stable or unstable angina pectoris and had chronic total occlusion were included in our study. Blood samples were collected from all patients before the angiography procedure. Coronary collateral circulation (CCC) was graded according to the Rentrop grading system of 0–3. Rentrop grades of 0 and 1 indicated low-grade CCC group, whereas grades 2 and 3 indicated high-grade CCC group. We divided our patients into two groups as low-grade CCC and high-grade CCC and examined these two groups in terms of uric acid / HDL ratios. Group 1: Rentrop classification grade 0–1 (mean age, 63,9±9,9), Group 2: Rentrop classification grade 2–3 (mean age, 62,1±9,4).Results    The baseline characteristics were similar in both groups. Uric acid / High density lipoprotein-cholesterol ratios and uric acid levels were higher in group 1 with poor collateral circulation [group 1; 0,21 (0,07–0,39) vs. group 2; 0,16 (0,08–0,31), group 1; 8,2 (3,4–10,4) vs. group 2; 5,85 (3,5–7,7), p<0,001, p<0,001 respectively].Conclusions    We found that high Uric acid / High-density lipoprotein-cholesterol ratios and high uric acid levels are associated with poor collateral circulation.

scholarly journals Effect of selenium and melatonin on some parameters Related to metabolic syndrome induced by Acryl amide in male rats (Part I)

2017 ◽  
Vol 40 (2) ◽  
pp. 140-146
Author(s):  
Khalisa Khadim Khudair
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Central Obesity ◽  
Sodium Selenite ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Male Rats

     This study was designed to investigate the ameliorative role of sodium selenite and melatonin on   acryl amide induced metabolic syndrome in adult male rats. Twenty (20) adult male rats were randomly and equally divided into 4 groups (G1, G2, G3 and G4) and were treated orally for seven weeks G1, (control group) was given distilled water, G2 were given orally 1mg/kg /B.W of Acryl amide, G3 group received 1mg/kg /B.W of Acryl amide followed by 0.5 mg/Kg/ B.W. of sodium selenite orally. G4 group received 1 mg/kg /B.W of acryl amide (orally) followed by 8 mg/Kg/ B.W. melatonin (IP/ injection). Fasting blood samples were collected by cardiac puncture at (0, 7 weeks) of the experiment for measuring serum total cholesterol, triacylglycerol, high density lipoprotein-cholesterol and serum uric acid, in addition to measuring waist circumference .The results showed an occurrence of central obesity, hyper uricemia, dyslipidemia (hyper cholesterolemia, triacyleglycerolemia and lowered high density lipoprotein-cholesterol concentration) in acryl amide treated animals. The results also indicated the alleviation of the changes in the above- mentioned parameters related to metabolic syndrome by sodium selenite and melatonin through lowering central obesity, total cholesterol, triacylglycerol, elevation of serum high density lipoprotein-cholesterol and lowering in serum uric acid.

scholarly journals Non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio serve as a predictor for coronary collateral circulation in chronic total occlusive patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ya Li ◽  
Xin Chen ◽  
Shu Li ◽  
Yulin Ma ◽  
Jialing Li ◽  
...  
Keyword(s):  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Collateral Circulation ◽  
Independent Predictor ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Coronary Collateral Circulation ◽  
Cholesterol Ratio ◽  
Spearman Test

Abstract Objective The present study investigated the potential correlation between non-high-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio (non-HDL-C/HDL) and the formation of coronary collateral circulation (CCC) in coronary artery disease cases with chronic total occlusive (CTO) lesions. Methods Two experienced cardiologists identified and selected patients with CTO lesions for retrospective analysis. The 353 patients were divided into a CCC poor formation group (Rentrop 0–1 grade, n = 209) and a CCC good formation group (Rentrop 2–3 grade, n = 144) based on the Cohen-Rentrop standard. A comparison of non-HDL-C/HDL ratios between the two groups was performed. The Spearman test was used to obtain the correlation between the cholesterol ratio and Rentrop grade. Independent predictors of CCC were analyzed using logistic regression. Receiver operating characteristic (ROC) curve analysis was also performed to quantify the predictive value of research indicator. Results The non-HDL-C/HDL ratio in the CCC poor formation group was elevated markedly compared to the CCC good formation group [( 3.86 ± 1.40) vs ( 3.31 ± 1.22), P = 0.000]. The Spearman test results indicated that non-HDL-C/HDL negatively correlated with Rentrop grade (r = − 0.115, P = 0.030). Multivariate logistic regression analysis showed that non-HDL-C/HDL ratio was an independent predictor of CCC formation (OR = 1.195, 95%CI = 1.020–1.400, P = 0.027). The area under the curve of ROC for detecting CCC poor formation was 0.611 (95% CI: 0.551–0.671, P = 0.000) with an optimal cut-off value of 2.77. Conclusion Non-HDL-C/HDL negatively correlated with the formation of CCC and served as an independent predictor of CCC formation, which may be used as a biomarker for the evaluation of CCC.

scholarly journals Effect of acrylamide and fructose on some parameters related to metabolic syndrome in adult male rats

2016 ◽  
Vol 40 (1) ◽  
pp. 125-135
Author(s):  
Khalisa Khadhim Khudiar
Keyword(s):  
Metabolic Syndrome ◽  
Drinking Water ◽  
Uric Acid ◽  
High Density Lipoprotein ◽  
Adult Male ◽  
High Density Lipoprotein Cholesterol ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Male Rats

     This study is designed to investigate the effect of acrylamide on some metabolic syndrome parameters in adult male rats relative to fructose. Forty adult male rats were randomly divided into four equal groups (ten rat/group) and treated for 60 days as follows: Control: Rats in this group were received distilled water orally, groups T1 and T2: rats of these groups were given orally 0.5 and 1mg/kg B.W acrylamide respectively. Animals in the fourth (T3) group were given 40% fructose in drinking water. Blood samples were collected by cardiac puncture technique at different periods 0, 30 and 60 day of the experiment for measuring serum concentration of the following parameters related to metabolic syndrome: Dyslipidemia (high density lipoprotein-cholesterol, and triacylglycerol), uric acid and glutathione. The result revealed that oral intubation of two concentration of acrylamide or exposure of rats to 40% fructose in drinking water caused disturbance in lipid metabolism manifested by triacylglycerolemia, lowered high density lipoprotein-cholesterol concentration, lowered serum uric acid and glutathione concentration with hyperuricemia. These functional changes were accompanied by structural changes in the kidney. Sections in rat's kidney showed renal damage manifested by desquamation and degeneration of epithelial cells of renal tubule as well as lymphocyte infiltration between renal tubules. The results of this study concluded that acrylamide succeeded to induce sever changes in parameters related to metabolic syndrome in rats as does the fructose (the well-known inducer of metabolic syndrome). According to the available literature it seems that this is the first study which showed the effect of acrylamide on some parameters related to metabolic syndrome.                                                             

Triglyceride to high density lipoprotein cholesterol ratio, total cholesterol to high density lipoprotein cholesterol ratio and low ankle brachial index in an elderly population

VASA ◽  
2014 ◽  
Vol 43 (3) ◽  
pp. 189-197 ◽  
Author(s):  
Yiqiang Zhan ◽  
Jinming Yu ◽  
Rongjing Ding ◽  
Yihong Sun ◽  
Dayi Hu
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
High Density Lipoprotein Cholesterol ◽  
Ankle Brachial Index ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Lipid Lowering ◽  
Cholesterol Ratio ◽  
Potential Biomarker

Background: The associations of triglyceride (TG) to high-density lipoprotein cholesterol ratio (HDL‑C) and total cholesterol (TC) to HDL‑C ratio and low ankle brachial index (ABI) were seldom investigated. Patients and methods: A population based cross-sectional survey was conducted and 2982 participants 60 years and over were recruited. TG, TC, HDL‑C, and low-density lipoprotein cholesterol (LDL-C) were assessed in all participants. Low ABI was defined as ABI ≤ 0.9 in either leg. Multiple logistic regression models were applied to study the association between TG/HDL‑C ratio, TC/HDL‑C ratio and low ABI. Results: The TG/HDL‑C ratios for those with ABI > 0.9 and ABI ≤ 0.9 were 1.28 ± 1.20 and 1.48 ± 1.13 (P < 0.0001), while the TC/HDL‑C ratios were 3.96 ± 1.09 and 4.32 ± 1.15 (P < 0.0001), respectively. After adjusting for age, gender, body mass index, obesity, current drinking, physical activity, hypertension, diabetes, lipid-lowering drugs, and cardiovascular disease history, the odds ratios (ORs) with 95 % confidence intervals (CIs) of low ABI for TG/HDL‑C ratio and TC/HDL‑C ratio were 1.10 (0.96, 1.26) and 1.34 (1.14, 1.59) in non-smokers. When TC was further adjusted, the ORs (95 % CIs) were 1.40 (0.79, 2.52) and 1.53 (1.21, 1.93) for TG/HDL‑C ratio and TC/HDL‑C ratio, respectively. Non-linear relationships were detected between TG/HDL‑C ratio and TC/HDL‑C ratio and low ABI in both smokers and non-smokers. Conclusions: TC/HDL‑C ratio was significantly associated with low ABI in non-smokers and the association was independent of TC, TG, HDL‑C, and LDL-C. TC/HDL‑C might be considered as a potential biomarker for early peripheral arterial disease screening.

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