scholarly journals Unusual occurrence of two sister tumours in the same patient- gastrointestinal stromal tumour and gastrointestinal autonomic nerve tumour

2018 ◽  
Vol 5 (2) ◽  
pp. 752
Author(s):  
Abhijeet Bagul ◽  
Nandhkishore Narwade ◽  
Sridevi Murali ◽  
Yashraj Shah
Keyword(s):  
Case Reports ◽  
Gastrointestinal Stromal Tumour ◽  
Stromal Tumour ◽  
Autonomic Nerve ◽  
Gastrointestinal Stromal Tumours ◽  
Hereditary Syndromes ◽  
Gastrointestinal Tumours ◽  
Unusual Occurrence ◽  
Ileocecal Intussusception ◽  
Nerve Tumour

Gastrointestinal stromal tumours (GIST) account for less than 1% of gastrointestinal tumours, whereas Gastrointestinal autonomic nerve tumour (GANT) is a rare variant of gastrointestinal stromal tumour (GIST) and occurs at an estimated frequency of 1% of all malignant gastrointestinal tumours. We report the case of a 38-year old male which represents the rarity in the incidence of a Gastrointestinal Stromal tumour as well as the occurrence of a gastrointestinal autonomic nerve tumour together in the same patient which presented as a jejunal lump along with a terminal ileocecal intussusception. Multiple GISTs are associated with familial or hereditary syndromes are described only in few case reports whereas multiple sporadic GISTs have been rarely reported. This review aims to report the multiple sporadic occurrence of two types of GISTs as well as discuss highlight the features and prognosis of GANTs as surgeons and gastroenterologists are unaware of the existence of such an entity.

scholarly journals Spontaneous perforation of jejunal gastrointestinal stromal tumour presenting with multiple intraperitoneal abscess cavities: a case report and review of literature

2016 ◽  
Vol 2 (8) ◽  
pp. 207
Author(s):  
Indrajit Rana ◽  
Jugindra Sorokhaibam
Keyword(s):  
Case Report ◽  
Gastrointestinal Stromal Tumour ◽  
Stromal Tumour ◽  
Spontaneous Perforation ◽  
Review Of Literature ◽  
Gastrointestinal Stromal Tumours ◽  
Gastrointestinal Tumours

Gastrointestinal stromal tumours (GISTs) account for less than 1% of gastrointestinal tumours. Perforation of GIST is very rare (0.8%) and it is infrequently described in the literature. We report a case of 53 years old gentleman who had spontaneous perforation of jejunal GIST with multiple intraperitoneal abscess cavities which is unique and extremely rare.

scholarly journals Synchronous Epithelioid Stromal Tumour and Lipoma in the Stomach

2003 ◽  
Vol 17 (6) ◽  
pp. 374-375 ◽  
Author(s):  
Nabeel Al-Brahim ◽  
Jasim Radhi ◽  
John Gately
Keyword(s):  
Carcinoid Tumour ◽  
Case Reports ◽  
Polypoid Lesion ◽  
Gastrointestinal Stromal Tumour ◽  
Partial Gastrectomy ◽  
Stromal Tumour ◽  
Resected Stomach ◽  
Mesenchymal Tumors ◽  
Distal Stomach ◽  
First Case

An 82-year-old man presented with upper gastrointestinal bleeding. A polypoid lesion of the distal stomach with focal ulceration was seen at endoscopy. This was treated by a partial gastrectomy. The resected stomach contained two separate tumours near the pylorus: a gastrointestinal stromal tumour (GIST) and an adjacent lipoma. The literature includes case reports of synchronously occurring GIST and adenocarcinoma, GIST and mucosa-associated lymphoid tissue lymphoma and GIST and carcinoid tumour. Herein is the first case report of two distinct mesenchymal tumors coexisting in the stomach.

scholarly journals Refractory hypercalcaemia secondary to localised gastrointestinal stromal tumour

2018 ◽  
Vol 100 (6) ◽  
pp. e136-e138 ◽  
Author(s):  
T Hart ◽  
D Sinitsky ◽  
A Shamsiddinova ◽  
A Rohatgi
Keyword(s):  
Abdominal Pain ◽  
Abdominal Cavity ◽  
Gastrointestinal Stromal Tumour ◽  
Stromal Tumour ◽  
Unusual Complication ◽  
Treatment Resistant ◽  
Gastrointestinal Stromal Tumours ◽  
Rare Form ◽  
Abdominal Neoplasm ◽  
Mesenchymal Tissue

Gastrointestinal stromal tumours are a rare form of intra-abdominal neoplasm derived from mesenchymal tissue, typically presenting with abdominal pain, anaemia or bleeding into the bowel or abdominal cavity. Hypercalcaemia is an unusual complication, having been documented in only seven previous patients, all of whom had advanced metastatic disease. We present a case of treatment-resistant hypercalcaemia in a patient with non-metastatic gastrointestinal stromal tumour, which resolved following excision of the tumour.

scholarly journals Familial wild-type gastrointestinal stromal tumour in association with germline truncating variants in both SDHA and PALB2

2021 ◽  
Author(s):  
James Whitworth ◽  
◽  
Ruth T. Casey ◽  
Philip S. Smith ◽  
Olivier Giger ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Succinate Dehydrogenase ◽  
Ductal Carcinoma ◽  
Gastrointestinal Stromal Tumour ◽  
Stromal Tumour ◽  
Wild Type ◽  
Mesenchymal Neoplasm ◽  
Predisposition Genes ◽  
High Heritability ◽  
Unusual Occurrence

AbstractGastrointestinal stromal tumour (GIST) is a mesenchymal neoplasm arising in the gastrointestinal tract. A rare subset of GISTs are classified as wild-type GIST (wtGIST) and these are frequently associated with germline variants that affect the function of cancer predisposition genes such as the succinate dehydrogenase subunit genes (SDHA, SDHB, SDHC, SDHD) or NF1. However, despite this high heritability, familial clustering of wtGIST is extremely rare. Here, we report a mother–son diad who developed wtGIST at age 66 and 34 years, respectively. Comprehensive genetic testing revealed germline truncating variants in both SDHA (c.1534C>T (p.Arg512*)) and PALB2 (c.3113G>A (p.Trp1038*)) in both affected individuals. The mother also developed breast ductal carcinoma in-situ at age 70 years. Immunohistochemistry and molecular analysis of the wtGISTs revealed loss of SDHB expression and loss of the wild-type SDHA allele in tumour material. No allele loss was detected at PALB2 suggesting that wtGIST tumourigenesis was principally driven by succinate dehydrogenase deficiency. However, we speculate that the presence of multilocus inherited neoplasia alleles syndrome (MINAS) in this family might have contributed to the highly unusual occurrence of familial wtGIST. Systematic reporting of tumour risks and phenotypes in individuals with MINAS will facilitate the clinical interpretation of the significance of this diagnosis, which is becoming more frequent as strategies for genetic testing for hereditary cancer becomes more comprehensive.

The gist of it: Case reports of a gastrointestinal stromal tumour and a leiomyoma of the anorectum

2003 ◽  
Vol 73 (3) ◽  
pp. 167-169 ◽  
Author(s):  
Ravi L. Huilgol ◽  
Christopher J. Young ◽  
Michael J. Solomon
Keyword(s):  
Case Reports ◽  
Gastrointestinal Stromal Tumour ◽  
Stromal Tumour

Imatinib-induced haematuria necessitating drug discontinuation

2020 ◽  
Vol 4 (3) ◽  
pp. 121-123
Author(s):  
Anandu Hemakumar ◽  
Keechilat Pavithran
Keyword(s):  
Kinase Inhibitors ◽  
Advanced Disease ◽  
Gastrointestinal Stromal Tumour ◽  
Stromal Tumour ◽  
Drug Discontinuation ◽  
Gastrointestinal Stromal Tumours ◽  
Old Adult ◽  
History Of ◽  
Improvement In Survival ◽  
Gross Haematuria

Gastrointestinal stromal tumours are rare neoplasms of the gastrointestinal tract that are mesenchymal in origin. The introduction of tyrosine kinase inhibitors resulted in significant improvement in survival of patients with gastrointestinal stromal tumour even in advanced disease conditions. A 43-year-old adult male who is a known case of gastrointestinal stromal tumour of the stomach, on adjuvant therapy with imatinib, presented with a history of gross haematuria of several episodes as well as persistent microhaematuria and was evaluated for the same. He was investigated for all possible causes, but all were negative. The patient was advised to withhold imatinib. Haematuria resolved 1 month after stopping imatinib. Then it was rechallenged. He had recurrence of symptoms, so it was discontinued. In view of the temporal relation of haematuria and administration of imatinib, a diagnosis of imatinib-induced haematuria was made.

16. Is it a gist or what? Two case reports of desmoid tumour in patients with previous gastrointestinal stromal tumour

Pathology ◽  
2014 ◽  
Vol 46 ◽  
pp. S111-S112
Author(s):  
Mahtab Farzin ◽  
Parag Sharma ◽  
Timothy Teo ◽  
Robert Eckstein ◽  
Bryn Atmore
Keyword(s):  
Case Reports ◽  
Gastrointestinal Stromal Tumour ◽  
Stromal Tumour ◽  
Desmoid Tumour
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