scholarly journals Extraappendiceal goblet cell carcinoid of the transverse colon

2021 ◽  
Vol 8 (2) ◽  
pp. 730
Author(s):  
Madison Bowles
Keyword(s):  
Stem Cells ◽  
Goblet Cell ◽  
Transverse Colon ◽  
Literature Search ◽  
Neuroendocrine Tumours ◽  
Intestinal Epithelial ◽  
Tumour Stage ◽  
Goblet Cell Carcinoid ◽  
Crypt Base

Goblet cell carcinoids (GCC) are a rare subgroup of neuroendocrine tumours which exhibit mixed endocrine and exocrine features and are almost exclusively localised to the appendix. A few cases of extraappendiceal GCC have been reported in the literature however these are exceedingly rare. They are biologically aggressive tumours that are believed to arise from pluripotent intestinal epithelial crypt base stem cells. Given their rarity, no guidelines currently exist for the management of extraappendiceal GCC, however treatment for GCC’s is generally based on their tumour stage in line with staging for typical adenocarcinomas. This case gives an account of a colonic goblet cell carcinoid within the transverse colon encountered in a 66-year-old male. A literature search did not identify any previous documented cases of a GCC at this location.  

Recent Patents Applications in Red Biotechnology: A Mini-Review

2019 ◽  
Vol 13 (3) ◽  
pp. 170-186 ◽  
Author(s):  
Raíssa C.D. Graciano ◽  
Júlia A.T. Ribeiro ◽  
Anderson K.S. Macêdo ◽  
José Paulo de S. Lavareda ◽  
Pedro R. de Oliveira ◽  
...  
Keyword(s):  
United States ◽  
Stem Cells ◽  
Cancer Research ◽  
Molecular Diagnostics ◽  
Literature Search ◽  
The United States ◽  
Therapeutic Antibodies ◽  
Diagnostic Kits

Background: The different fields of biotechnology can be classified by colors, as a "rainbow" methodology. In this sense, the red biotechnology, focused on the preservation of health, has been outstanding in helping to solve this challenge through the provision of technologies, including diagnostic kits, molecular diagnostics, vaccines, innovations in cancer research, therapeutic antibodies and stem cells. Objective: The main goal of this work is to highlight the different areas within the red Biotechnology. In this sense, we revised some patents regarding red biotechnology as examples to cover this subject. Methods: A literature search of patents was performed from the followings Patents Database: INPI, USPTO, Esp@cenet, WIPO and Google Patents. Results: Our analysis showed the following numbers from patents found: cancer research (8), diagnosis kit (9), vaccines (8), stem cells (9) and therapeutic antibodies (5), where the United States is the leader for most filled patents in Red Biotechnology. Conclusion: This mini-review has provided an update of some patents on Recent Patents in Red Biotechnology. As far as we know, this is the first mini-review report on Red Biotechnology based on patents.

scholarly journals Goblet cell carcinoid of the rectum: a case report

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Yoshiyuki Inoue ◽  
Hisanaga Horie ◽  
Yuko Homma ◽  
Ai Sadatomo ◽  
Makiko Tahara ◽  
...  
Keyword(s):  
Case Report ◽  
Goblet Cell ◽  
Goblet Cell Carcinoid

scholarly journals Adenocarcinoma Ex Goblet Cell Carcinoid of Appendix: Two Case Reports

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Yu-Ting Wang ◽  
Yi-Ru Li ◽  
Tuan-Ying Ke
Keyword(s):  
Acute Appendicitis ◽  
Acute Abdomen ◽  
Goblet Cell ◽  
Case Reports ◽  
Biological Behavior ◽  
Rare Tumor ◽  
Goblet Cell Carcinoid

Adenocarcinoma ex goblet cell carcinoid is a rare tumor incidentally found in specimens of appendicitis. Most patients present with acute abdomen, similar to acute appendicitis. Here we present two cases, which were found incidentally after operation. We give a brief summary about clinical and biological behavior of this entity.

A further note on the measurement of the affinity of a dye (Azure A) for histological substrates

1965 ◽  
Vol s3-106 (76) ◽  
pp. 299-306
Author(s):  
D. J. GOLDSTEIN
Keyword(s):  
Adsorption Isotherm ◽  
Goblet Cell ◽  
Binding Sites ◽  
Langmuir Isotherm ◽  
Langmuir Adsorption Isotherm ◽  
Intestinal Epithelial ◽  
Langmuir Adsorption ◽  
Azure A ◽  
First Approximation ◽  
The Ideal

If two histological sections, of thickness nµ and 2nµ, and having the same apparent intensity of staining, are at equilibrium with dyebaths of concentration B1 and B2 respectively, the affinity of the histological substrate for the dye is, under denned conditions, given by the expression ΔF° = - RT In I/B, where B is either (i) B2 if the thinner section is stained to saturation, or (ii) B1 if B1 = 3B2. The affinity tends to be greater when measured in a weaker dyebath, as implied in method (ii). Evidence is presented suggesting that the uptake of the basic dye Azure A by pancreatic basal chromidial substance, goblet cell mucin and intestinal epithelial cytoplasm follows a Langmuir adsorption isotherm to a first approximation, in that, at low dyebath concentrations, the uptake of dye is proportional to the concentration of dyebath with which the substrate is in equilibrium, while in strong dyebaths the uptake approaches a plateau. A deviation from the ideal Langmuir isotherm in dyebaths of moderate concentration, observed in epithelial cytoplasm and to a lesser extent in pancreatic basal chromidial substance, may have been due to interaction between neighbouring dye-binding sites, or to the presence in a single area of sites with different affinities for the dye.

Adenocarcinoma ex-goblet cell carcinoid of the ascending colon concurrent with conventional adenocarcinoma

Pathology ◽  
2018 ◽  
Vol 50 (7) ◽  
pp. 789-792 ◽  
Author(s):  
Kyu Yun Jang ◽  
Ho Sung Park ◽  
Sang Jae Noh ◽  
Ho Lee ◽  
Min Ro Lee
Keyword(s):  
Goblet Cell ◽  
Ascending Colon ◽  
Goblet Cell Carcinoid

scholarly journals Immunostaining of Lgr5, an Intestinal Stem Cell Marker, in Normal and Premalignant Human Gastrointestinal Tissue

2008 ◽  
Vol 8 ◽  
pp. 1168-1176 ◽  
Author(s):  
Laren Becker ◽  
Qin Huang ◽  
Hiroshi Mashimo
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Stem Cell Niche ◽  
Intestinal Stem Cells ◽  
Stem Cell Marker ◽  
Tumor Initiating Cells ◽  
Colonic Adenomas ◽  
Potential Marker ◽  
Cell Niche ◽  
Crypt Base

Lgr5 has recently been identified as a murine marker of intestinal stem cells. Its expression has not been well characterized in human gastrointestinal tissues, but has been reported in certain cancers. With the increasing appreciation for the role of cancer stem cells or tumor-initiating cells in certain tumors, we sought to explore the expression of Lgr5 in normal and premalignant human gastrointestinal tissues. Using standard immunostaining, we compared expression of Lgr5 in normal colon and small intestine vs. small intestinal and colonic adenomas and Barrett's esophagus. In the normal tissue, Lgr5 was expressed in the expected stem cell niche, at the base of crypts, as seen in mice. However, in premalignant lesions, Lgr5+cells were not restricted to the crypt base. Additionally, their overall numbers were increased. In colonic adenomas, Lgr5+cells were commonly found clustered at the luminal surface and rarely at the crypt base. Finally, we compared immunostaining of Lgr5 with that of CD133, a previously characterized marker for tumor-initiating cells in colon cancer, and found that they identified distinct subpopulations of cells that were in close proximity, but did not costain. Our findings suggest that (1) Lgr5 is a potential marker of intestinal stem cells in humans and (2) loss of restriction to the stem cell niche is an early event in the premalignant transformation of stem cells and may play a role in carcinogenesis.

Comment on the Article by Chetty et al on Combined Classical Carcinoid and Goblet Cell Carcinoid Tumor

2011 ◽  
Vol 35 (8) ◽  
pp. 1248-1250
Author(s):  
Tze Sheng Khor ◽  
Jian Shen ◽  
Gregory Y. Lauwers ◽  
Vikram Deshpande
Keyword(s):  
Carcinoid Tumor ◽  
Goblet Cell ◽  
Goblet Cell Carcinoid
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