scholarly journals Solitary polypoid ganglioneuroma in the sigmoid colon: a rare finding during colonoscopy

2021 ◽  
Vol 8 (3) ◽  
pp. 1063
Author(s):  
Madison Bowles
Keyword(s):  
Gastrointestinal Tract ◽  
Sigmoid Colon ◽  
Histological Analysis ◽  
Ganglion Cells ◽  
Screening Colonoscopy ◽  
Phenotypic Characteristics ◽  
S 100 ◽  
Protein Immunoreactivity ◽  
Benign Tumours ◽  
Specific Symptoms

Ganglioneuromas (GN) are rare, benign tumours of the autonomic nervous system which are seldom encountered in the gastrointestinal tract. They may occur as solitary lesions or more commonly as multiple lesions, also known as ganglioneuromatosis. Endoscopically they have no identifiable phenotypic characteristics and therefore diagnosis can only be confirmed through histological analysis. Microscopically they are composed of ganglion cells, nerve fibres and Schwann cells and show S-100 protein immunoreactivity. Clinically, there are no specific symptoms eluding towards the diagnosis of solitary ganglioneuromas of the gastrointestinal tract with most patients remaining asymptomatic. Due to their rarity, no guidelines current exists for solitary colonic GNs, however consensus exists that endoscopic resection is curative with no evidence of recurrence following total excision. This case gives an account of a solitary colonic ganglioneuroma in the sigmoid colon encountered during a screening colonoscopy in a 47-year-old male.

scholarly journals Endoscopic Treatment of Solitary Colonic Ganglioneuroma

2020 ◽  
Vol 14 (1) ◽  
pp. 34-38
Author(s):  
Toshio Arai ◽  
Hiroki Yamada ◽  
Takeya Edagawa ◽  
Satoshi Yoshida ◽  
Shunji Maekura ◽  
...  
Keyword(s):  
Ganglion Cells ◽  
Occult Blood ◽  
Fecal Occult Blood ◽  
Neurofibromatosis I ◽  
Fecal Occult ◽  
Electromagnetic Resonance ◽  
Spindle Cell Proliferation ◽  
Old Japanese ◽  
S 100 ◽  
Protein Immunoreactivity

Ganglioneuromas (GNs) in adults are uncommon clinical entities, especially in the colon. Patients with GNs without multiple endocrine neoplasia or neurofibromatosis-I are normally asymptomatic; however, GNs can present with abdominal pain, weight loss, bleeding, and anemia, depending on the size and location. Here, we present a case of solitary colonic GN treated with endoscopic mucosal resection. A 40-year-old Japanese outpatient with a positive fecal occult blood test visited our hospital. We performed diagnostic colonoscopy, which revealed a polyp of 15-mm diameter in the ascending colon. Electromagnetic resonance imaging was performed, and the histological examination revealed benign polypoid spindle-cell proliferation, ganglion cells, and thick nerve bundles, which was positive for S-100 protein immunoreactivity consistent with GN.

scholarly journals Case Report: Schwannoma of the sigmoid colon: a case report of a rare colonic neoplasm and review of literature

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 652
Author(s):  
Gangmi Kim ◽  
Sun Il Kim ◽  
Kang Young Lee
Keyword(s):  
Case Report ◽  
Sigmoid Colon ◽  
Tumor Cells ◽  
Surgical Resection ◽  
Submucosal Tumor ◽  
Regional Lymph Node ◽  
Screening Colonoscopy ◽  
Resection Margins ◽  
Resected Specimen ◽  
S 100

Background: Schwannomas are tumors originating in Schwann cells of the peripheral nerve system and uncommonly develop in the gastrointestinal tract. Sigmoid colon schwannomas are very rare and only 28 cases have been reported. This study aims to report a case of a sigmoid colon schwannoma and present a literature review. Case report: We report a case of a 66-year-old female with asymptomatic sigmoid colon schwannoma. The patient underwent a screening colonoscopy and about 4cm sized submucosal tumor was identified at the sigmoid colon. A colonoscopic biopsy was performed and the microscopic exam revealed an ulcerated lesion with a proliferation of fibroblast-like spindle cells beneath ulcer, which was insufficient for diagnosis. Abdominopelvic computerized tomography (CT) scan showed a well-defined, well-enhancing, round shaped and slightly heterogenous mass at the sigmoid colon. No distant metastasis was identified in abdominopelvic CT and chest CT scans. Carcinoembryonic antigen level was within a normal range (1.33ng/mL). The patient underwent laparoscopic anterior resection. Immunohistochemical staining of the resected specimen showed positivity for S-100 protein in tumor cells and schwannoma was diagnosed post-surgically. Surgical resection margins were free from tumor and no regional lymph node metastasis was reported. Conclusion: Colon schwannomas are rare diseases. Most cases of colon schwannomas are accidentally identified during screening colonoscopy. The tumors usually present as submucosal masses and colonoscopic biopsies are mostly non-diagnostic. Surgical resection is required, and definitive diagnosis is made by confirming S-100 positive tumor cells in immunohistochemical analysis. Most cases are benign; a few cases have been reported to be malignant. Surgical resection with free negative margins is the treatment of choice

Gangliocytic Paraganglioma of the Duodenum: Case Report

1987 ◽  
Vol 73 (4) ◽  
pp. 425-429 ◽  
Author(s):  
Stefania Dante ◽  
Giuseppe Viale ◽  
Paolo Dalla Palma
Keyword(s):  
Case Report ◽  
Ganglion Cells ◽  
Neuron Specific Enolase ◽  
Gangliocytic Paraganglioma ◽  
Spindle Cells ◽  
S 100 ◽  
Neurofilament 200

A case of gangliocytic paraganglioma of the second portion of the duodenal loop is presented. The tumor was polypoid and, histologically, composed of mature ganglion cells, spindle cells and epithelial-like cells. Immunocytochemical examination demonstrated the presence of neurofilament 200 K and S-100 protein only in the first two types of cells; all the cells were positive for neuron-specific enolase. The reaction for cytokeratin was negative in all neoplastic components. According to morphologic and immunocytochemical findings, we suggest a hamartomatous nature of this entity.

scholarly journals A Case of Benign Schwannoma of the Ascending Colon Treated With Laparoscopic-Assisted Wedge Resection

2013 ◽  
Vol 98 (4) ◽  
pp. 315-318 ◽  
Author(s):  
Se-Jin Baek ◽  
Won Hwangbo ◽  
Jin Kim ◽  
In-Sun Kim
Keyword(s):  
Submucosal Tumor ◽  
Wedge Resection ◽  
Ascending Colon ◽  
Mesenchymal Tumors ◽  
Benign Schwannoma ◽  
S 100 ◽  
Colon And Rectum ◽  
Laparoscopic Assisted ◽  
Specific Symptoms ◽  
Diffuse Positivity

Abstract Isolated colonic schwannomas are rare gastrointestinal mesenchymal tumors. Only a small number of cases have been reported. Occurrence of these tumors is more common in the stomach than in the large intestine. These spindle cell lesions are distinct from leiomyoma, leiomyosarcoma, and gastrointestinal stromal tumors because the tumor cells have a distinct immunophenotype, with strong diffuse positivity for S-100 and vimentin, as well as corroborative negative staining of CD117 and smooth muscle markers. We present a case of colonic schwannoma in a 70-year-old woman who had no specific symptoms. The patient was diagnosed with a submucosal tumor in the ascending colon on colonoscopy and abdominal computed tomography. Laparoscopic-assisted wedge resection of colon was performed. The very rare pathologic diagnosis of ascending schwannoma was made postoperatively. This case is interesting because schwannomas of the colon and rectum are extremely rare and are treated by laparoscopic-assisted wedge resection.

scholarly journals Asymptomatic Perforated Appendicitis Presenting as a Subepithelial Sigmoid Colon Lesion at Screening Colonoscopy

2015 ◽  
Vol 89 (5) ◽  
pp. 548-552
Author(s):  
Yu Yi Choi ◽  
Su Jin Kim ◽  
Dae Hwan Kang ◽  
Hyung Wook Kim ◽  
Cheol Woong Choi ◽  
...  
Keyword(s):  
Sigmoid Colon ◽  
Perforated Appendicitis ◽  
Screening Colonoscopy ◽  
Colon Lesion

Cecal Mucosal Myxoma: The First Report of a New Type of Mesenchymal Colon Polyp

2019 ◽  
Vol 27 (6) ◽  
pp. 693-696
Author(s):  
Caroline Bsirini ◽  
Jennifer J. Findeis-Hosey ◽  
Aaron R. Huber
Keyword(s):  
Case Reports ◽  
Colonic Polyp ◽  
Screening Colonoscopy ◽  
Unknown Etiology ◽  
Positive Staining ◽  
Gi Tract ◽  
Sessile Polyp ◽  
First Case ◽  
S 100 ◽  
New Type

Myxomas are benign mesenchymal neoplasms of unknown etiology that most commonly occur in the cardiac atrium; however, other reported sites include the skin, joints, skeletal muscles, maxillofacial bones, and sinonasal tract. Myxomas involving the gastrointestinal (GI) tract are rare and are limited to a few published case reports. We are presenting, to our knowledge, the first case report of a mucosal myxoma in the colon presenting as a colonic polyp. A 49-year-old woman underwent a screening colonoscopy and was found to have a 0.2-cm sessile polyp in the cecum. Histologically, the polyp was composed of bland spindled cells in the lamina propria set in a hypocellular, myxoid stroma. The lesion was relatively well-demarcated from the surrounding mucosa. The overlying colonic epithelium showed no dysplasia. S-100 immunohistochemical stain showed only focal nonspecific positivity, while CD34, CD117, SMA, EMA, and desmin were all negative. Alcian blue special stain showed positive staining, supporting the diagnosis of myxoma. Myxomas in the GI tract are very rare, with this being the first reported case of a polypoid colonic mucosal myxoma. Previous reports of GI myxomas are limited to examples in the stomach, small bowel, and one recently reported case in the colon, all of which were submucosal lesions and not limited to the mucosa. In some of the prior reports, the patients had synchronous cardiac atrial myxomas. Mucosal colonic myxoma represents a newly identified mesenchymal polyp of the colon and pathologists should be aware of this diagnostic entity.

scholarly journals Intrauterine device removal from the sigmoid colon during a screening colonoscopy

Endoscopy ◽  
2015 ◽  
Vol 47 (S 01) ◽  
pp. E446-E446 ◽  
Author(s):  
Ana García-Rodríguez ◽  
Marco Álvarez ◽  
Agustin Seoane
Keyword(s):  
Sigmoid Colon ◽  
Intrauterine Device ◽  
Screening Colonoscopy ◽  
Device Removal

S-100 Protein Immunoreactivity in the Upper Eyelid of the Sheep Ovis aries

2003 ◽  
Vol 35 (5) ◽  
pp. 457-462
Author(s):  
J. Aisa ◽  
M. Lahoz ◽  
P. Serrano ◽  
M.C. Pérez-Castejón ◽  
C. Junquera ◽  
...  
Keyword(s):  
Ovis Aries ◽  
Upper Eyelid ◽  
S 100 ◽  
Protein Immunoreactivity

Absence of S-100 Protein Immunoreactivity in Cellular Blue Nevus: A Potential Diagnostic Pitfall

1999 ◽  
Vol 7 (4) ◽  
pp. 255
Author(s):  
Angelo P. Dei Tos ◽  
Jasvir S. Khurana ◽  
Paul J. Kurtin ◽  
Antonio G. Nascimento
Keyword(s):  
Blue Nevus ◽  
Diagnostic Pitfall ◽  
S 100 ◽  
Protein Immunoreactivity ◽  
Cellular Blue Nevus

scholarly journals Lipoma of the sigmoid colon

2013 ◽  
Vol 70 (3) ◽  
pp. 319-321 ◽  
Author(s):  
Matilda Djolai ◽  
Bojana Andrejic ◽  
Dejan Ivanov
Keyword(s):  
Adipose Tissue ◽  
Case Report ◽  
Gastrointestinal Tract ◽  
Sigmoid Colon ◽  
Human Body ◽  
Soft Tissues ◽  
Benign Tumor ◽  
Extensive Resection ◽  
One Year ◽  
Histological Confirmation

Introduction. Lipoma is a benign tumor of adipose tissue, the most common tumor of the human body soft tissues. As such, it can be found almost anywhere in the human body including the gastrointestinal system (incidence below 0.5%), but rarely in the sigmoid colon. Case report. This is a case report on symptomatic polyp of the sigmoid colon, which after one year, at control colonoscopy, caused suspicion to malignancy. Endoscopically diagnosed polipoid lesion was laparoscopically removed. The pathohistological diagnosis determined benign, submucosal, incapsulated lipoma of the sigmoid colon. Conclusion. Although lipomas of the gastrointestinal tract are rare, this case clearly indicates that we should not prematurely and without histological confirmation of malignancy do more extensive resection for a suspected malignancy.

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