scholarly journals Case Report: Schwannoma of the sigmoid colon: a case report of a rare colonic neoplasm and review of literature

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 652
Author(s):  
Gangmi Kim ◽  
Sun Il Kim ◽  
Kang Young Lee
Keyword(s):  
Case Report ◽  
Sigmoid Colon ◽  
Tumor Cells ◽  
Surgical Resection ◽  
Submucosal Tumor ◽  
Regional Lymph Node ◽  
Screening Colonoscopy ◽  
Resection Margins ◽  
Resected Specimen ◽  
S 100

Background: Schwannomas are tumors originating in Schwann cells of the peripheral nerve system and uncommonly develop in the gastrointestinal tract. Sigmoid colon schwannomas are very rare and only 28 cases have been reported. This study aims to report a case of a sigmoid colon schwannoma and present a literature review. Case report: We report a case of a 66-year-old female with asymptomatic sigmoid colon schwannoma. The patient underwent a screening colonoscopy and about 4cm sized submucosal tumor was identified at the sigmoid colon. A colonoscopic biopsy was performed and the microscopic exam revealed an ulcerated lesion with a proliferation of fibroblast-like spindle cells beneath ulcer, which was insufficient for diagnosis. Abdominopelvic computerized tomography (CT) scan showed a well-defined, well-enhancing, round shaped and slightly heterogenous mass at the sigmoid colon. No distant metastasis was identified in abdominopelvic CT and chest CT scans. Carcinoembryonic antigen level was within a normal range (1.33ng/mL). The patient underwent laparoscopic anterior resection. Immunohistochemical staining of the resected specimen showed positivity for S-100 protein in tumor cells and schwannoma was diagnosed post-surgically. Surgical resection margins were free from tumor and no regional lymph node metastasis was reported. Conclusion: Colon schwannomas are rare diseases. Most cases of colon schwannomas are accidentally identified during screening colonoscopy. The tumors usually present as submucosal masses and colonoscopic biopsies are mostly non-diagnostic. Surgical resection is required, and definitive diagnosis is made by confirming S-100 positive tumor cells in immunohistochemical analysis. Most cases are benign; a few cases have been reported to be malignant. Surgical resection with free negative margins is the treatment of choice

Schwannoma Arising from the Tentorium at an Unusual Location: Case Report

Neurosurgery ◽  
2002 ◽  
Vol 50 (6) ◽  
pp. 1352-1355 ◽  
Author(s):  
Akihiro Oikawa ◽  
Naoto Takeda ◽  
Nobuhiko Aoki ◽  
Touichiro Takizawa ◽  
Takaaki Sakoma
Keyword(s):  
Case Report ◽  
Tumor Cells ◽  
Cystic Mass ◽  
Dense Adhesion ◽  
Inferior Surface ◽  
Truncal Ataxia ◽  
Dural Tail Sign ◽  
S 100 ◽  
Dural Tail ◽  
History Of

Abstract OBJECTIVE AND IMPORTANCE We present a case of schwannoma attached to the tentorium. CLINICAL PRESENTATION A 41-year-old woman without evidence of neurofibromatosis presented with a 3-month history of headache, positional vertigo, and truncal ataxia. Magnetic resonance imaging revealed an extra-axial cystic mass lesion in the left anteromedial cerebellar region with a dural tail sign. INTERVENTION The tumor was removed completely by retrosigmoid craniotomy. Dense adhesion of the tumor to the inferior surface of the tentorium was confirmed during surgery. On light microscopic study, this neoplasm was composed of spindle cells and showed palisaded structures. Immunohistochemically, the tumor cells stained positive for S-100 protein and vimentin. Reticulin staining revealed a pericellular pattern of distribution of reticulin fibers. Electron microscopy confirmed the presence of a basement membrane encompassing the tumor cells. From these findings, the tumor was diagnosed as a schwannoma arising from the tentorium. CONCLUSION To our knowledge, this case report is the first to describe a schwannoma arising from the tentorium. Our case report indicates that schwannoma is a possible pathology in the differential diagnosis of dura-based tumors.

scholarly journals Gastric Schwannoma: A Postoperative Surprise A Case Report.

2014 ◽  
Vol 1 (1) ◽  
pp. 23-25
Author(s):  
Abdelmounaim Ait ALi ◽  
Mohamed Essarghini ◽  
Abderzak Hajjouji ◽  
Khalid Sair
Keyword(s):  
Case Report ◽  
Clinical Case ◽  
Submucosal Tumor ◽  
S100 Protein ◽  
Partial Gastrectomy ◽  
Definitive Diagnosis ◽  
Resected Specimen ◽  
Stromal Tumors ◽  
Gastric Schwannoma ◽  
Slow Growing

Gastric Schwannoma is a rare, slow-growing, and clinically non-specific submucosal tumor, originating from Schwann cells with excellent prognosis after surgical resection. We report a clinical case of a patient presented with gastric schwannoma revealed by non-specific gastric signs and of which the definitive diagnosis is done through immunohistochemistry of the resected specimen, showing strong S100 protein positivity. The evolution is favorable after a partial gastrectomy with a decline of two years. Through this case, we are trying to trace the rarity, strong similarities with gastric stromal tumors and especially, the weak index of suspicion for this diagnosis.

Colonic Neurogenic Lesion: An Admixture of Mucosal Neurofibromatous Lesion and Submucosal Ganglioneuromatous Lesion With Transition

2020 ◽  
Vol 28 (5) ◽  
pp. 563-568
Author(s):  
Hirotsugu Hashimoto ◽  
Hirotomo Koda ◽  
Hajime Horiuchi ◽  
Maho Takayama ◽  
Junya Toyoda ◽  
...  
Keyword(s):  
Sigmoid Colon ◽  
Submucosal Tumor ◽  
Immunohistochemical Analysis ◽  
Resected Specimen ◽  
Rare Occurrence ◽  
Supporting Cells ◽  
Rectosigmoid Junction ◽  
Submucosal Lesions ◽  
Tumor Like Lesions ◽  
Single Lesion

Benign neural tumors or tumor-like lesions are rarely detected in the gastrointestinal tract. In this article, we present the case of a neural lesion of the sigmoid colon, which was incidentally detected in a 68-year-old man treated with laparoscopic low anterior resection for an advanced carcinoma of the rectosigmoid junction. Within the resected specimen, a submucosal tumor-like protruding lesion was found in the sigmoid colon. Histologically, the growth was composed of mucosal neurofibromatous and submucosal ganglioneuromatous lesions, between which there was transition. Immunohistochemical analysis revealed a rupture of the perineurium in the area of transition, along with a proliferation of Schwann cells and supporting cells extending into the deep mucosa. This transition indicated that the mucosal and submucosal lesions comprised a single lesion, and that a diagnosis of neurofibroma or ganglioneuroma would be inadequate in this case. Because we could not classify it as an established single entity, we diagnosed the mass as an unclassifiable colonic neurogenic lesion. In summary, we report the case of an extremely rare occurrence of an unclassifiable colonic neurogenic lesion comprising an admixture of transitioning mucosal neurofibromatous and submucosal ganglioneuromatous lesions.

scholarly journals A Rare Cancer of the Tongue That Showed Unusual Histology and Immunohistochemical Phenotype: Case Report

2017 ◽  
Vol 1 ◽  
Author(s):  
Yae Ohata ◽  
Rei Tohyama ◽  
Kou Kayamori ◽  
Hiroaki Shimamoto ◽  
Yuka Hirota ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Neck Dissection ◽  
Tumor Cells ◽  
Rare Case ◽  
Tongue Cancer ◽  
Submucosal Tumor ◽  
Rare Cancer ◽  
Cytokeratin 7 ◽  
Not Otherwise Specified

<p class="AbstractContent">We report a rare case of primary tongue cancer that showed unusual clinical, histological and immunohistological features. The patient was a 73-year-old man who presented with a submucosal tumor in the left side of tongue. Treatment consisted of preoperative chemotherapy, hemiglossectomy, unilateral neck dissection and postoperative chemo-radiotherapy. The tumor locates in the submucosa, independently of the overlying tongue epithelium and the salivary gland. The tumor showed infiltrating growth, arranged in cord or trabecular nests without keratinization or distinct duct formation. The tumor cells were positive for pan-keratin, cytokeratin 7 (CK7) and p63, but negative for other specific markers. Since this tumor did not match any of the defined entity, we diagnosed this lesion as carcinoma, not otherwise specified of the tongue.</p>

scholarly journals Multiple non-polypoid mucosal Schwann cell hamartomas presenting as edematous and submucosal tumor-like lesions: a case report

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Takeshi Okamoto ◽  
Takaaki Yoshimoto ◽  
Katsuyuki Fukuda
Keyword(s):  
Schwann Cell ◽  
Sigmoid Colon ◽  
Submucosal Tumor ◽  
Distal Colon ◽  
Screening Colonoscopy ◽  
Neurofilament Protein ◽  
Neurogenic Tumors ◽  
Asymptomatic Patients ◽  
Tumor Like Lesions

Abstract Background Mucosal Schwann cell hamartomas are rare neurogenic tumors which present most commonly in the distal colon. They are usually discovered as small, single polyps in asymptomatic patients. Case presentation An asymptomatic 64-year-old man was referred to us after a 12 mm subepithelial lesion was discovered incidentally on screening colonoscopy. Follow-up colonoscopy conducted 2 months later revealed that the tumor had disappeared, leaving multiple edematous, submucosal tumor-like elevations presenting as skip lesions throughout the sigmoid colon. Lesions had elongated pits on magnifying endoscopy and were limited to the first layer on endoscopic ultrasound. Biopsies revealed unclearly delineated foci of spindle-shaped cells limited to the lamina propria. On immunohistochemistry, all lesions were positive for S-100 protein and negative for CD34, CD56, and neurofilament protein. The patient was diagnosed with multiple mucosal Schwann cell hamartomas of the sigmoid colon. He remains asymptomatic after 18 months of follow-up, but the lesions have also remained unchanged. Conclusion We report a case of multiple non-polypoid mucosal Schwann cell hamartomas. Endoscopic findings may assist in the differential diagnosis, particularly when presenting as non-polypoid, submucosal tumor-like lesions.

scholarly journals A rare simultaneous coexistence of epithelioid gastrointestinal stromal tumors and schwannoma in the stomach: a case report

2019 ◽  
Vol 14 (1) ◽  
Author(s):  
Yuxin Li ◽  
Yongliang Teng ◽  
Xiaofei Wei ◽  
Zhuang Tian ◽  
Yuqing Cao ◽  
...  
Keyword(s):  
Case Report ◽  
Tumor Cells ◽  
Gastrointestinal Stromal Tumors ◽  
Simultaneous Occurrence ◽  
Correct Identification ◽  
Stromal Tumors ◽  
Gastric Schwannoma ◽  
Disease Pattern ◽  
S 100 ◽  
Lesser Curvature

Abstract Background Gastrointestinal stromal tumors (GISTs), a type of mesenchymal tumor in the gastrointestinal tract, are believed to be closely associated with PDGFRA and C-KIT mutations. Schwannoma in the stomach, which is an unusual location, is a rare disorder. The simultaneous occurrence of the two diseases is rarer than metachronous occurrences, and its pathological characteristics have not been reported to date. We present a case report on a patient with simultaneous coexistence of gastric schwannoma and GISTs. Case presentation A 39-year-old female visited our hospital complaining of intermittent abdominal pain for the previous 3 months. CT revealed a 3.4 cm slight homogeneous enhancement in the lesser curvature of the stomach; the mass was nodular soft tissue, which was removed by radical surgery. Two solid tumors with different volumes were located in the stomach. Histologically and immunohistochemically different, the larger tumor consisted of spindle cells surrounded by a peripheral lymphoid cuff, and was positive for S-100. The larger tumor was therefore classified as a gastric schwannoma. The smaller tumor was composed of medium-sized round, oval cells with amphiphilic granular cytoplasm; vacuolization was also observed. The tumor cells were positive for DOG1 and sporadically positive for CD34 and CD117. Hence, the smaller tumor was diagnosed as epithelioid GISTs. Sanger sequencing revealed that the GIST tumor cells contained a deletion mutation (c.2527_2538 del12,843–846del4), which was located in exon 18 of PDGFRA. Conclusion GISTs combined with gastric schwannoma are a considerably rare subgroup of gastric tumors. Related clinical research is comparatively weak, and the mechanism remains unknown. We reviewed related articles to provide knowledge to improve the correct identification, diagnosis and management of patients with gastric cancer. All pathologists involved in the diagnosis and clinicians involved in the treatment should be aware of this new kind of disease pattern to improve their understanding of the disease.

Prostaglandin E1-effective, transient-type ischemic colitis developed after surgical resection of sigmoid colon cancer. A case report

2003 ◽  
Vol 15 (3) ◽  
pp. 240-242 ◽  
Author(s):  
YUKAKO ISHIHARA ◽  
MASAHIRO SEIKE ◽  
ITARU YOKOUCHI ◽  
HIROAKI SUDA ◽  
SHUNICHIRO ISHITSUKA ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Case Report ◽  
Sigmoid Colon ◽  
Surgical Resection ◽  
Ischemic Colitis ◽  
Prostaglandin E1 ◽  
Sigmoid Colon Cancer

scholarly journals Solitary polypoid ganglioneuroma in the sigmoid colon: a rare finding during colonoscopy

2021 ◽  
Vol 8 (3) ◽  
pp. 1063
Author(s):  
Madison Bowles
Keyword(s):  
Gastrointestinal Tract ◽  
Sigmoid Colon ◽  
Histological Analysis ◽  
Ganglion Cells ◽  
Screening Colonoscopy ◽  
Phenotypic Characteristics ◽  
S 100 ◽  
Protein Immunoreactivity ◽  
Benign Tumours ◽  
Specific Symptoms

Ganglioneuromas (GN) are rare, benign tumours of the autonomic nervous system which are seldom encountered in the gastrointestinal tract. They may occur as solitary lesions or more commonly as multiple lesions, also known as ganglioneuromatosis. Endoscopically they have no identifiable phenotypic characteristics and therefore diagnosis can only be confirmed through histological analysis. Microscopically they are composed of ganglion cells, nerve fibres and Schwann cells and show S-100 protein immunoreactivity. Clinically, there are no specific symptoms eluding towards the diagnosis of solitary ganglioneuromas of the gastrointestinal tract with most patients remaining asymptomatic. Due to their rarity, no guidelines current exists for solitary colonic GNs, however consensus exists that endoscopic resection is curative with no evidence of recurrence following total excision. This case gives an account of a solitary colonic ganglioneuroma in the sigmoid colon encountered during a screening colonoscopy in a 47-year-old male.

Metastatic Liposarcoma of the Skull Base: A Case Report and Review of Literature

Neurosurgery ◽  
2017 ◽  
Vol 80 (4) ◽  
pp. 219-223 ◽  
Author(s):  
Nirmeen Zagzoog ◽  
Greta Ra ◽  
Alex Koziarz ◽  
John Provias ◽  
Doron Sommer ◽  
...  
Keyword(s):  
Case Report ◽  
Skull Base ◽  
Surgical Resection ◽  
Nerve Palsy ◽  
Myxoid Liposarcoma ◽  
Resection Margins ◽  
Subtotal Resection ◽  
Sixth Nerve Palsy ◽  
Scapular Region ◽  
Sixth Nerve

Abstract BACKGROUND AND IMPORTANCE: Myxoid liposarcoma is not an uncommon form of sarcoma. However, it usually affects the lower extremity long bones. Scapular involvement is extremely rare, as is a metastasis to the parasellar region. We present a case of liposarcoma of the skull base originating in the scapular region and metastasizing to the sellar and parasellar regions and provide a review of the pertinent literature. CLINICAL PRESENTATION: A 43-year-old female patient diagnosed with left scapular myxoid liposarcoma was treated with surgical resection. She had clear resection margins and was treated pre- and postoperatively with radiotherapy to the region. She remained asymptomatic for 2 years following surgery, after which she abruptly developed diplopia with right lateral gaze. There were no symptoms of raised intracranial pressure or impaired vision. Her examination was normal apart from complete right sixth nerve palsy. Imaging studies of the brain showed a large mass in the clivus eroding into the floor of the sella, encircling the right internal carotid artery in the cavernous sinus. The mass also displaced the sellar contents superiorly. An endonasal, endoscopic skull base approach was undertaken, and a subtotal resection was performed in an effort to avoid multiple cranial nerve pareses. CONCLUSION: Our literature search revealed that this case report is the first to document liposarcoma metastasis to the skull base originating from the scapular region. Subtotal surgical resection resulted in minimal improvement of the patient's sixth nerve palsy. Postoperative radiation was undertaken. A multidisciplinary approach on an individual patient basis is recommended.

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