scholarly journals Video assisted surgery: a unique approach for non-resolving retroperitoneal abscess

2021 ◽  
Vol 8 (3) ◽  
pp. 1026
Author(s):  
Prashant Kumar ◽  
Sanjay Chaurey ◽  
Rudra P. Mishra ◽  
Irfan F. Kar ◽  
Aditya Gupta

Abdominal gunshot injuries and its management has always been challenging for surgeons. Challenges start from diagnosis and extent of injury and its immediate management and further its long term complications and their management. Injuries extending up to retroperitoneal space complicated by abscess formation are difficult to manage because the retroperitoneal space is relatively inaccessible leading to very poor outcome, and a tailor made approach is the best method of treatment for an individual patient. Current study report a rare case of video assisted approach for non-resolving retro-peritoneal abscess caused by abdominal gunshot injury with previous laparotomy and unilateral nephrectomy (left-side) with retro-peritoneal abscess along with sepsis, acute renal failure and hemopneumothorax.

2001 ◽  
Vol 59 (4) ◽  
pp. 1333-1341 ◽  
Author(s):  
Josephine Maree Forbes ◽  
Timothy David Hewitson ◽  
Gavin James Becker ◽  
Colin Lindsay Jones

1989 ◽  
Vol 35 (1) ◽  
pp. 84-89 ◽  
Author(s):  
Helen N. Georgaki-Angelaki ◽  
David B. Steed ◽  
Cyril Chantler ◽  
George B. Haycock

1969 ◽  
Vol 131 (2) ◽  
pp. 610-614 ◽  
Author(s):  
F. D. McDonald ◽  
G. Thiel ◽  
D. R. Wilson ◽  
G. F. DiBona ◽  
D. E. Oken

1991 ◽  
pp. 101-106
Author(s):  
Quirino Maggiore ◽  
G. Enia ◽  
G. Catalano ◽  
C. Martorano ◽  
F. Bartolomeo

2008 ◽  
Vol 23 (6) ◽  
pp. 2095-2097 ◽  
Author(s):  
H. Uta ◽  
K. Michael ◽  
P. Hermann ◽  
H. Martin ◽  
B. Eckhart

Author(s):  
V. Bonomini ◽  
A. Vangelista ◽  
G. Frasca ◽  
S. Stefoni ◽  
M. P. Scolari ◽  
...  

2016 ◽  
Author(s):  
Tugrul Burak Genc ◽  
Yildiz Okuturlar ◽  
Hakan Kocoglu ◽  
Samet Sayilan ◽  
Yesim Ozdem Inan ◽  
...  

Pharmaceutics ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 714
Author(s):  
Sung Hun Bae ◽  
Sun-Young Chang ◽  
So Hee Kim

Tofacitinib is a Jak inhibitor developed as a treatment for rheumatoid arthritis. Tofacitinib is metabolized mainly through hepatic CYP3A1/2, followed by CYP2C11. Rheumatoid arthritis tends to increase renal toxicity due to drugs used for long-term treatment. In this study, pharmacokinetic changes of tofacitinib were evaluated in rats with gentamicin (G-ARF) and cisplatin-induced acute renal failure (C-ARF). The time-averaged total body clearance (CL) of tofacitinib in G-ARF and C-ARF rats after 1-min intravenous infusion of 10 mg/kg was significantly decreased by 37.7 and 62.3%, respectively, compared to in control rats. This seems to be because the time-averaged renal clearance (CLR) was significantly lower by 69.5 and 98.6%, respectively, due to decreased creatinine clearance (CLCR). In addition, the time-averaged nonrenal clearance (CLNR) was also significantly lower by 33.2 and 57.4%, respectively, due to reduction in the hepatic CYP3A1/2 and CYP2C11 subfamily in G-ARF and C-ARF rats. After oral administration of tofacitinib (20 mg/kg) to G-ARF and C-ARF rats, both CLR and CLNR were also significantly decreased. In conclusion, an increase in area under plasma concentration-time curves from time zero to time infinity (AUC) of tofacitinib in G-ARF and C-ARF rats was due to the significantly slower elimination of tofacitinib contributed by slower hepatic metabolism and urinary excretion of the drug.


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