Amniotic band syndrome: a case series

Amniotic band syndrome (ABS) is a rare congenital disorder which involves fetal entrapment in strands of amniotic tissue, which can manifest as constriction rings, limb and digital amputations or complex congenital anomalies and sometimes results in stillbirth. Etiopathogenesis is varied and ABS can be associated with syndromes. Antenatal diagnosis is made by ultrasonography in most cases. Postnatal examination reveals constrictions, amputations and craniofacial or abdominal wall defects. Treatment is case based and surgical intervention is required to release constriction rings. Authors report here six cases (one stillbirth and five live births) of amniotic band syndrome that were encountered over the last one and half years.

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One-stage circumferential limb ring constriction release and direct circular skin closure in amniotic band syndrome: a 14-case series

Orthopaedics & Traumatology Surgery & Research ◽

10.1016/j.otsr.2020.06.009 ◽

2020 ◽

Vol 106 (7) ◽

pp. 1353-1359

Author(s):

Benjamin Dufournier ◽

Stéphane Guero ◽

Marine de Tienda ◽

Caroline Dana ◽

Nicolas Garcelon ◽

...

Keyword(s):

Case Series ◽

Skin Closure ◽

Amniotic Band ◽

Amniotic Band Syndrome ◽

One Stage ◽

Ring Constriction

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Role of Ultrasound in Body Stalk Anomaly and Amniotic Band Syndrome

International Journal of Reproductive Medicine ◽

10.1155/2016/3974139 ◽

2016 ◽

Vol 2016 ◽

pp. 1-10 ◽

Cited By ~ 4

Author(s):

Madhavilatha Routhu ◽

Sreedevi Thakkallapelli ◽

Prashanthi Mohan ◽

Nadeem Ahmed

Keyword(s):

First Trimester ◽

Unknown Etiology ◽

Abdominal Wall Defects ◽

Body Parts ◽

Patient Counselling ◽

Amniotic Band ◽

Developmental Abnormalities ◽

Amniotic Band Syndrome ◽

Limb Deformities ◽

Craniofacial Defects

Body stalk anomaly (BSA) and amniotic band syndrome (ABS) are rare similar fetal sporadic polymalformative syndromes of unknown etiology, though there are certain differences between them. BSA is a combination of developmental abnormalities involving neural tube, body wall, and the limbs with persistent extra embryonic coelomic cavity. ABS is characterized by the presence of thin membrane-like strands attached to fetal body parts and causing constrictions and amputations. This is a cohort study involving 32,100 patients who were referred for routine antenatal ultrasound scan. The data was entered prospectively into a computer database. The duration of study was 3 years. In our study, ultrasound examination in 86 patients demonstrated ventral wall defects, craniofacial defects, and spinal and limb deformities as isolated or combined abnormalities. In those, 10 patients were suspected/diagnosed as BSA/ABS including a twin of a dichorionic diamniotic gestation. The typical features of body stalk anomaly can be detected by ultrasound by the end of the first trimester, which is important for the patient counselling and management. We are presenting these rare conditions and highlighting the importance of early sonographic imaging in diagnosing and differentiating them from other anterior abdominal wall defects.

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Complex Congenital Heart Defect, Heterotaxy, Imperforate Anus, and Other Congenital Anomalies in a 27-Week Infant: A Case Study

Neonatal Network The Journal of Neonatal Nursing ◽

10.1891/0730-0832.33.4.199 ◽

2014 ◽

Vol 33 (4) ◽

pp. 199-203 ◽

Cited By ~ 1

Author(s):

Angela Koerner

Keyword(s):

Congenital Anomalies ◽

Intraventricular Hemorrhage ◽

Congenital Heart ◽

Surgical Intervention ◽

First Year ◽

Risk Of Infection ◽

Cardiac Defects ◽

Live Births ◽

First Year Of Life

According to multiple researchers and studies, congenital heart disease (CHD) occurs in approximately 4.8–12.0 of 1,000 live births in the general population, and 2.4 per 1,000 cases are serious enough to require surgery or cardiac catheterization in the first year of life.1 Historically, it has been assumed that the earlier the gestational age with CHD, the poorer the outcome; however, with continued improvements in neonatal care, this hypothesis should be looked at more closely. This case illustrates the challenges associated with prematurity, complex cardiac defects, intraventricular hemorrhage (IVH), and other congenital anomalies that increase the risk of infection and/or surgical intervention. It will discuss the hospital course of a twin, born at 27 weeks gestation, who was found to have all of these diagnoses, yet, despite the complexity of his case, he had a predominantly uncomplicated hospital course.

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Amniotic Band Syndrome: A Case Series

Journal of Pregnancy and Child Health ◽

10.4172/2376-127x.1000109 ◽

2014 ◽

Vol 01 (01) ◽

Author(s):

Srinivasan H Dhungel P

Keyword(s):

Case Series ◽

Amniotic Band ◽

Amniotic Band Syndrome

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A Neonate with Amniotic Band Syndrome and Osteomyelitis

10.21203/rs.3.rs-80180/v1 ◽

2020 ◽

Author(s):

Nazanin Zafaranloo ◽

Fereshteh Moshfegh ◽

Parisa Mohagheghi ◽

Babak Beigi ◽

Elahe Nourozi

Keyword(s):

Congenital Malformations ◽

Chronic Osteomyelitis ◽

Amniotic Band ◽

Case Presentation ◽

Live Births ◽

Amniotic Band Syndrome ◽

Interprofessional Teamwork ◽

Males And Females ◽

Anatomic Region

Abstract Background: Amniotic band syndrome (ABS) comprises of a spectrum of congenital malformations involving the limbs more often, but any other anatomic region of fetus could be involved (1). Its prevalence has been reported to range from 0.19 to 8.1 per 10000 live births (2). There are different theories for explaining the etiology of amniotic bands, but it has been considered to have a multifactorial etiology. (2) Fetoscopic release of amniotic bands affecting one or more extremities can prevent limb loss or preserve limb function when distal fellow is still identifiable on preoperative ultrasound scans (3)(4). ABS occurs in 77% of fetuses with multiple anomalies (5). Both males and females are equally affected (6). Osteomyelitis in neonates is relatively uncommon, but burdened with an increased hospital stay and possible long‐term sequela if not diagnosed on time (18). The long bones are the most frequently affected sites (18).Case presentation: Here we are introducing a neonate with left upper extremity necrosis due to ABS which needed amputation and it was associated with severe chronic osteomyelitis.Conclusion: Amniotic band syndrome mostly involves the limbs. It is important to diagnose it as soon as possible, because with the interprofessional teamwork approach, an optimal patient result with fetoscopic or surgery procedures could be achieved.

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Prenatal ultrasonographic diagnosis of limb body wall complex

Nepal Journal of Obstetrics and Gynaecology ◽

10.3126/njog.v2i2.1460 ◽

1970 ◽

Vol 2 (2) ◽

pp. 72-74

Author(s):

Narayan B Thapa ◽

Ganesh Dangal ◽

Aruna Karki

Keyword(s):

Key Words ◽

Abdominal Wall ◽

Umbilical Cord ◽

Body Wall ◽

Abdominal Wall Defects ◽

Amniotic Band ◽

Wall Defect ◽

Ultrasonographic Diagnosis ◽

Amniotic Band Syndrome ◽

Rare Combination

In this report, a case of limb body wall complex (LBWC) diagnosed by ultrasonography is presented. Limbbody wall complex refers to a rare combination of disruptive and lethal abnormalities which start early in the gestational process. Abnormalities commonly associated with this disorder include cranio-facial abnormalities, scoliosis, ventral body wall defect (thoraco-abdominoschisis), limb deformations, short umbilical cord, and others. Other terms used to describe similar findings include short umbilical cord syndrome, body-stalk anomaly, and amniotic band syndrome. This complex should be distinguished from other body-wall defects including omphalocele and gastroschisis since the prognosis for limb-body wall complex is uniformly poor. The diagnosis of limb-body wall complex can be made by prenatal sonography. Key words: limb body wall complex, abdominal wall defects, amniotic bands, amniotic band syndrome, ultrasonography. doi:10.3126/njog.v2i2.1460 N. J. Obstet. Gynaecol 2007 Nov-Dec; 2 (2): 72 - 74

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P22.12: Antenatal diagnosis of amniotic band syndrome-case report

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.7370 ◽

2009 ◽

Vol 34 (S1) ◽

pp. 265-266

Author(s):

S. Kabra

Keyword(s):

Case Report ◽

Antenatal Diagnosis ◽

Amniotic Band ◽

Amniotic Band Syndrome

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Prevalência de Cardiopatias Congénitas em Portugal em 2015: Dados do Registo Nacional de Anomalias Congénitas

Acta Médica Portuguesa ◽

10.20344/amp.12111 ◽

2020 ◽

Vol 33 (7-8) ◽

pp. 491

Author(s):

Isabel Saraiva de Melo ◽

Paula Braz ◽

Rita Roquette ◽

Paulo Sousa ◽

Carla Nunes ◽

...

Keyword(s):

Congenital Heart Disease ◽

Heart Disease ◽

Congenital Anomalies ◽

Congenital Heart ◽

Chromosomal Abnormalities ◽

Antenatal Diagnosis ◽

National Registry ◽

Critical Congenital Heart Disease ◽

Live Births ◽

Congenital Birth Defects

Introduction: The prevalence at birth of congenital heart disease in Portugal is 8.3/1000 births; undetected critical congenital heart disease may result in adverse outcomes for the fetus/newborn infant. This study describes the reported cases of congenital heart disease in Portugal in 2015 regarding antenatal diagnosis, cardiac defect, and presence of other congenital anomalies/chromosomal abnormalities. These indicators are compared in live births and medical pregnancy terminations. Additionally, postnatal deaths were characterized.Material and Methods: Congenital heart disease data derived from the 2015 Portuguese National Registry of Congenital Birth Defects were analyzed. The prevalence rates per 1000 births were assessed by the chi-square test of independence.Results: The prevalence of congenital heart disease in this study was 5/1000 live-births (339 live-births, 20% with critical defects). The most common defects were ventricular septal defect (38%), atrial septal defect (15%), aortic coarctation (7%), tetralogy of Fallot (7%) and pulmonary stenosis (5%). One third of the live births had antenatal diagnosis of congenital heart disease. In the live-births with critical congenital heart disease, 54% had antenatal diagnosis and 14% were diagnosed at birth. There were records of 84 pregnancy terminations; 49% had critical defects, 75% had non-cardiac congenital anomalies and 40% had chromosomal abnormalities. There were 15 postnatal deaths recorded (3.4% mortality rate), associated with prematurity/low birthweight, critical congenital heart disease, other non-cardiac congenital anomalies and chromosomal abnormalities.Discussion: The data analysis revealed a prevalence of congenital heart disease in this study of 5/1000 births (inferior to other international studies), with a distribution per type of anomaly similar to that reported in previously published work. There were significant regional differences that need further studying.Conclusion: These results are paramount to characterize the Portuguese scenario and improve Healthcare planning. It is important to improve reporting in the Portuguese National Registry of Congenital Birth Defects.

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