scholarly journals Kikuchi-Fujimoto disease

2021 ◽  
Vol 8 (9) ◽  
pp. 1419
Author(s):  
Ashraf Alakkad ◽  
Mohamed Alakkad
Keyword(s):  
Cervical Lymphadenopathy ◽  
Needle Aspiration ◽  
Excision Biopsy ◽  
Medical Clinic ◽  
Asian Countries ◽  
Medical Problems ◽  
History Of ◽  
Necrotizing Lymphadenitis ◽  
Reticular Cells ◽  
The Uk

A lady from Sudan was referred to our medical clinic as a case of cervical lymphadenopathy with gradual enlargement. She had no complaint. The cervical lymphadenopathy was not associated with pain, fever, weight loss, cough, neither bleeding nor other associated swellings. There was no history of chronic medical problems including TB and underwent thorough investigations including LN biopsy. Lymphoma was initially suspected. Fine-needle aspiration and excision biopsy were undertaken. Histological analysis later suggested Kikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis. Kikuchi-Fujimoto disease (KFD) was described in 1972 as lymphadenitis with focal proliferation of reticular cells accompanied by numerous histiocytes and extensive nuclear debris. KFD, frequently found in East Asian countries, is rare in the UK. No definite etiology of KFD is known despite autoimmune and infection factors being suggested. The diagnostic hallmark is histological findings from lymph nodes. Steroid therapy could be used in severe cases. KFD is relatively unknown and this case report aims to highlight its occurrence in our population.

scholarly journals Kikuchi-Fujimoto Disease: A Case Report and Literature Review

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Vikrant Veer ◽  
Albert Lim ◽  
Wolfgang Issing
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Lymph Nodes ◽  
Needle Aspiration ◽  
Excision Biopsy ◽  
Asian Countries ◽  
Histiocytic Necrotising Lymphadenitis ◽  
History Of ◽  
Reticular Cells ◽  
The Uk

Case. 38-year-old lady was referred to the ENT clinic with history of right-sided facial pain, otalgia, and odynophagia. Clinical examination revealed enlarged right-sided lymph nodes in the neck. Further radiological scans showed a mass near the carotid and enlarged level V lymph nodes. Lymphoma was initially suspected. Fine-needle aspiration and excision biopsy were undertaken. Histological analysis later suggested Kikuchi-Fujimoto disease, also known as histiocytic necrotising lymphadenitis.Literature Review. Kikuchi-Fujimoto disease (KFD) was described in 1972 as lymphadenitis with focal proliferation of reticular cells accompanied by numerous histiocytes and extensive nuclear debris. KFD, frequently found in East Asian countries, is rare in the UK. No definite aetiology of KFD is known despite autoimmune and infection factors being suggested. The diagnostic hallmark is histological findings from lymph nodes. Malignancy should be excluded. This condition is mainly self-limiting; hence, management is limited to supportive care. Steroid therapy could be used in severe cases. KFD is relatively unknown in the UK and this case report aims to highlight its occurrence in our population.

scholarly journals Comparison of FNAC vs Excision Biopsy for suspected Tuberculous Cervical Lymphadenopathy

2016 ◽  
Vol 9 (3) ◽  
Author(s):  
Ajmal Farooq ◽  
Imran Ameen
Keyword(s):  
Cervical Lymphadenopathy ◽  
Needle Aspiration ◽  
Excision Biopsy ◽  
Tuberculous Lymphadenitis ◽  
Cervical Lymphadenitis ◽  
Aspiration Cytology ◽  
Safe Alternative ◽  
Associated Symptoms ◽  
History Of ◽  
Needle Aspiration Cytology

Although Excision Biopsy has traditionally been required to diagnose cervical tuberculous lymphadenitis tine needle aspiration cytology (FNAC) has also been found to be useful. This prospective study presents the comparison of FNAC vs Excision Biopsy for suspected tuberculous cervical lymphadenitis in 100 consecutive. The aim and objective of the study was to determine whether FNAC is helpful in diagnosing tuberculous cervical lymphadenopathy thus avoiding Excision Biopsy. Patients between 5-70 years of age with suspected tuberculous lymphadenitis were included. Among these 62% were female and 38% were male 74% belong to poor class and 26% to middle class. 86%, were having history of immunization again tuberculosis with BCG. While 14% had no such history. The neck swelling was present in all 100 patients with some percentage of associated symptoms. The FNAC was positive for tuberculosis in 80 (80%) patients and Excision Biopsy in 94(94%) patients. Excision Biopsy was more sensitive than FNAC (94% vs 80%) in diagnosing tuberculous cervical lymphadenopathy. So it was concluded that FNAC is a safe alternative to Excision Biopsy and it should be recommended as first line and Excision Biopsy as second line investigation only if results of FNAC are negative.

scholarly journals A rare and interesting case report of Kikuchi-Fujimoto disease masquerading as tuberculosis

2020 ◽  
Vol 7 (10) ◽  
pp. 3508
Author(s):  
Joel Danie Mathew ◽  
Ajithakumari K. ◽  
Jiby Soosen Ninan ◽  
Juby Sunny
Keyword(s):  
Extrapulmonary Tuberculosis ◽  
Cervical Lymphadenopathy ◽  
Interesting Case ◽  
Excision Biopsy ◽  
Post Operative Period ◽  
History Of ◽  
Necrotizing Lymphadenitis ◽  
High Index Of Suspicion ◽  
Very High

Kikuchi-Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a rare benign, self-limited condition, probably genetic, that mainly affects young women which often presents with localised lymphadenopathy and fever. Reporting the case of a 17-year-old girl, with a strong family history of tuberculosis, who presented to the surgery OPD with cervical lymphadenopathy and a history of anti-tubercular treatment for the same complaints two years back. An excision biopsy revealed necrotizing histiocytic lymphadenitis suggestive of KFD. Post-operative period was uneventful and patient had spontaneous resolution of her complaints upon follow up. It is quite difficult to make a pre-operative diagnosis of this disease, until the clinician has got a very high index of suspicion especially because of the more common differential diagnoses including extrapulmonary tuberculosis. 

scholarly journals Kikuchi-Fujimoto Disease in a Filipino Boy: A Case Report

2019 ◽  
Vol 34 (2) ◽  
pp. 35-38
Author(s):  
Jenina Rachel Escalderon ◽  
Angelo Monroy
Keyword(s):  
Case Report ◽  
Private Hospital ◽  
Cervical Lymphadenopathy ◽  
Excision Biopsy ◽  
Cervical Lymph Nodes ◽  
History Of ◽  
Necrotizing Lymphadenitis ◽  
Supportive Management ◽  
Multiple Diagnosis

Objective: To report a case of a 12-year-old boy with Necrotizing Lymphadenitis (Kikuchi-Fujimoto disease) presenting as lymphadenitis secondary to multiple diagnosis.   Methods: Design : Case Report Setting: Tertiary Private Hospital Patient: One   Results: A 12-year-old boy consulted for two-month history of cervical lymphadenopathy with the underlying cause remaining unclear despite multiple consults, diagnosis and medical treatment. Lymphoma was considered and excision biopsy with further investigations confirmed a diagnosis of Kikuchi-Fujimoto disease. Supportive management was given with no recurrence of symptoms noted on 18 months of follow up.    Conclusion:  Kikuchi-Fujimoto disease in this case was a diagnosis of exclusion. Even with a proper history and physical examination, experts in otolaryngology can be misled to manage this case as malignant. Awareness of the disease and appropriate examinations including immunohistochemistry are important for a timely diagnosis and proper intervention.   Keywords: lympadenitis; Kikuchi-Fujimoto disease; lymphoma; cervical lymph nodes

scholarly journals A prospective clinico-pathological study of cervical lymphadenopathy

2017 ◽  
Vol 4 (12) ◽  
pp. 3967
Author(s):  
Narender N. R. ◽  
Yadagiri Rao J.
Keyword(s):  
Lymph Nodes ◽  
Prospective Observational Study ◽  
Primary Tumour ◽  
Cervical Lymphadenopathy ◽  
Needle Aspiration ◽  
Excision Biopsy ◽  
Medical Sciences ◽  
Aspiration Cytology ◽  
Needle Aspiration Cytology ◽  
Carcinoma Tongue

Background: Lymphadenopathy refers to one or more lymph nodes that are abnormal in size, consistency or number. There are various causes for lymphadenopathy which range from benign conditions to malignant either primary or secondary from draining primary tumour. Lymphadenopathy can be localised to a single group or generalised.Methods: Prospective observational study was performed for the patients attending outpatient department of general surgery at Kamineni academy of medical sciences, LB nagar Hyderabad, Telangana with complaints of enlarged or swollen lymph nodes in the neck. This study included 46 cases. In cases where fine needle aspiration cytology was inconclusive and there was need for excision biopsy, only these cases were included in the study. After biopsy lymph node was sent for gross and microscopic examination for expert opinion from department of pathology.Results: The present study includes 46 patients in a period of two years from 01-8-2015 to 31-7-2017. Of these case tuberculosis lymphadenopathy (n=25,54.3%) was the most common aetiology followed by nonspecific chronic lymphadenopathy (n=16,34.7%) followed by some relatively rare cases and unusual presentation Schwannoma, pleomorphic adenoma, Kikuchi disease, non-Hodgkin’s lymphoma and secondaries from carcinoma tongue (n=1,2.1%).Conclusions: In the present prospective study tubercular lymphadenopathy was the most common cause for cervical lymphadenopathy followed by chronic nonspecific lymphadenopathy. 

Follicular lymphoma presenting as mumps, with persistent cervical lymphadenopathy

2006 ◽  
Vol 121 (5) ◽  
pp. 501-502 ◽  
Author(s):  
A S Cole ◽  
M I Trotter ◽  
J O'Connell
Keyword(s):  
Follicular Lymphoma ◽  
Sore Throat ◽  
Fine Needle Aspiration ◽  
Healthy Individual ◽  
Cervical Lymphadenopathy ◽  
Needle Aspiration ◽  
Excision Biopsy ◽  
Malignant Cells ◽  
Fine Needle

We report a case of follicular lymphoma in a healthy individual, which presented as saliva- and serum-proven mumps. The patient presented with a sore throat and parotid and submandibular lymphadenopathy. Fine needle aspiration, undertaken three weeks following presentation, revealed no malignant cells. An excision biopsy of a level two node was performed due to persistent lymphadenopathy, five weeks following presentation. As far as we are aware, this is the first reported case of follicular lymphoma presenting as mumps. This case highlights the importance of follow up in patients in whom lymphadenopathy is persistent despite the proven diagnosis of mumps.

Kikuchi—Fujimoto's Necrotizing Lymphadenitis in Association with Discoid Lupus Erthematosus: A Case Report

2004 ◽  
Vol 8 (6) ◽  
pp. 442-445
Author(s):  
Shane G. Silver ◽  
H. Chih-Ho Hong ◽  
Patricia T. Ting ◽  
Nigel J. Ball
Keyword(s):  
Lymph Node ◽  
Lupus Erythematosus ◽  
Histopathological Examination ◽  
Cervical Lymphadenopathy ◽  
Discoid Lupus Erythematosus ◽  
Erythematous Plaque ◽  
Nasal Bridge ◽  
Reticular Dermis ◽  
History Of ◽  
Necrotizing Lymphadenitis

Background: Kikuchi–Fujimoto's necrotizing lymphadenitis (KFNL) is a rare, benign, self-limited condition characterized by constitutional symptoms, lymphadenopathy, and skin lesions. Objective: We report a case of KFNL in a 43-year-old East Indian woman with a ten-year history of discoid lupus erythematosus (DLE) of the scalp and a three-month history of a erythematous plaque on the left nasal bridge, cervical lymphadenopathy, and fever. Skin biopsy samples were taken from the face and lymph node. Results: Histopathological examination of the skin revealed a mixed infiltrate of inflammatory cells, nuclear dust, and histiocytes phagocytosing nuclear debris in the reticular dermis. The lymph node showed interfollicular liquefactive necrosis, immunoblasts, and a similar cellular infiltrate as the skin. The non-necrotic areas demonstrated follicular hyperplasia. These pathological changes are associated with a diagnosis of KFNL. Conclusions: KFNL is reported in association with systemic lupus erythematosus, but only two other cases of systemic KFNL in association with DLE exist in the literature. This case is unique in that the patient presented with cutaneous and systemic KFNL in the setting of longstanding DLE.

scholarly journals Hashimoto’s Thyroiditis and Kikuchi’s Disease: Presentation of a Case and Review of the Literature

2012 ◽  
Vol 2012 ◽  
pp. 1-5
Author(s):  
Athanasios Saratziotis ◽  
Konstantinos Karakousis ◽  
Kelly Tzika ◽  
Katerina G. Oikonomou ◽  
Panagiotis J. Vlachostergios
Keyword(s):  
Hashimoto’S Thyroiditis ◽  
Cervical Lymphadenopathy ◽  
Hashimoto's Thyroiditis ◽  
Surgical Removal ◽  
Cervical Lymph Nodes ◽  
Kikuchi’S Disease ◽  
Long Term Follow Up ◽  
History Of ◽  
Necrotizing Lymphadenitis ◽  
Kikuchi's Disease

We report the case of a 19-year-old woman with a history of Hashimoto’s thyroiditis who presented with tender right anterior cervical lymphadenopathy and fever. Workup for infectious, autoimmune, and malignant causes was unremarkable. Surgical removal of cervical lymph nodes after detailed magnetic resonance (MR) imaging disclosed necrotizing lymphadenitis, also known as Kikuchi’s disease (KD). The patient was treated with a short-term course of steroids, due to the onset of pancytopenia and borderline antiphospholipid antibodies combined with increased anti-thyroglobulin (anti-TG) titers. Despite being a diagnosis of exclusion, KD should be included in the differential of such patients, particularly in cases of previous or concurrent autoimmune diseases such as Hashimoto’s thyroiditis, which necessitate a long-term follow-up.

scholarly journals Kikuchi's Disease: A Case Report

2014 ◽  
Vol 8 (2) ◽  
pp. 96-98
Author(s):  
Md Shafiq-Ur Rahman ◽  
Golam Muktadir ◽  
SK Abdul Momen Ahmed
Keyword(s):  
Early Recognition ◽  
Cervical Lymphadenopathy ◽  
Needle Aspiration ◽  
Lymph Node Biopsy ◽  
Unknown Etiology ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Cervical Lymphadenitis ◽  
Kikuchi’S Disease ◽  
Necrotizing Lymphadenitis ◽  
Kikuchi's Disease

Kikuchi's disease is also known as histiocytic necrotizing lymphadenitis. Kikuchi-Fujimoto disease (KFD) or histiocytic necrotizing lymphadenitis, is a rare benign, self-limiting cervical lymphadenitis of unknown etiology. It predominantly affects young women and can closely mimic infective and immunological disorders. Recognition of this condition is crucial, specially because it can easily be mistaken for tuberculosis, lymphoma, or even adenocarcinoma. We report an 18 years old girl who presented with fever and cervical lymphadenopathy. She had multiple enlarged cervical lymphadenopathy. Examination of other systems was normal. Laboratory investigations were also normal. Fine needle aspiration cytology of the cervical node was not done. The patient took a course of oral antibiotics. Since the patient did not respond, lymph node biopsy was done and the histological features suggested the diagnosis of Kikuchi's disease. The Patient was treated symptomatically and complete remission occurred in few weeks. Although the incidence of Kikuchi-Fujimoto disease is rare, clinicians should be aware of this condition as early recognition of the disease will minimize potentially harmful and unnecessary evaluations and treatments. DOI: http://dx.doi.org/10.3329/fmcj.v8i2.20395 Faridpur Med. Coll. J. 2013;8(2): 96-98

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