scholarly journals Allergic fungal rhinosinusitis: an overview on pathogenesis, early diagnosis and management

2018 ◽  
Vol 4 (3) ◽  
pp. 694 ◽  
Author(s):  
Neeraj Suri ◽  
Bhavya B. M.
Keyword(s):  
Nasal Obstruction ◽  
Endoscopic Sinus Surgery ◽  
Sinus Surgery ◽  
Histological Evaluation ◽  
Nasal Discharge ◽  
Fungal Sinusitis ◽  
Surgical Specimen ◽  
Specimen Handling ◽  
Fungal Rhinosinusitis ◽  
Allergic Fungal Rhinosinusitis

<p class="abstract"><strong>Background: </strong>The objective of the study was<strong> </strong>to evaluate the criteria for diagnosing allergic fungal rhinosinusitis and to maintain permanent drainage and ventilation, while preserving the integrity of the mucosa.</p><p class="abstract"><strong>Methods:</strong> This is a prospective study of 50 patients with allergic fungal sinusitis with or without polyposis all of whom were treated with endoscopic debridement. Mucous sample collection, nasal secretion culture, surgical specimen handling, and histological evaluation of surgical specimens are described. All patients treated with endoscopic sinus surgery, debridement, post-operative use of steroids and antifungal therapy.  </p><p class="abstract"><strong>Results:</strong> Fungal mucin was found in all 50 cases, histology and fungal cultures confirmed the diagnosis. Out of 50 patients, 29 were females and 21 were males, with a mean age of 32 years. The most common symptom was nasal discharge 41 (82%) cases, nasal obstruction in 38 (76%) cases, headache and facial pain in 32 (72%) cases, 7 (14%) patients had bronchial asthma. Symptoms of nasal obstruction and nasal discharge were improved in 46 (92%) cases. All preoperative versus postoperative changes in AFRS associated complaints reached statistical significance of p value &lt;0.001 except in patients with asthma.</p><p class="abstract"><strong>Conclusions:</strong> Comprehensive management with endoscopic sinus surgery, oral steroids and antifungals reduces the recurrence or need for revision surgery. Long term follow up is very important.</p>

Allergic fungal rhinosinusitis with skull base and orbital erosion

2009 ◽  
Vol 124 (2) ◽  
pp. 161-165 ◽  
Author(s):  
M S Marfani ◽  
M A Jawaid ◽  
S M Shaikh ◽  
K Thaheem
Keyword(s):  
Skull Base ◽  
Sinus Surgery ◽  
Common Finding ◽  
Nasal Discharge ◽  
Topical Steroids ◽  
Fungal Sinusitis ◽  
Fungal Rhinosinusitis ◽  
Allergic Fungal Rhinosinusitis ◽  
Postnasal Drip ◽  
Imaging Results

AbstractIntroduction:Allergic fungal rhinosinusitis is a benign, noninvasive sinus disease related to hypersensitivity to fungal infection having bony skull base and orbital erosion as common finding.Patients and method:This descriptive study was conducted at the department of otorhinolaryngology, Dow University of Health Sciences, Karachi, Pakistan, from April 2003 to March 2006. In forty-seven proven cases of allergic fungal sinusitis the following information was recorded: demographic data, signs and symptoms, laboratory investigation results, imaging results, pre- and post-operative medical treatment, surgery performed, follow up, and residual or recurrent disease. The Statistical Package for the Social Sciences version 10.0 software was used for data analysis.Results:Findings indicated that allergic fungal rhinosinusitis usually occurred in the second decade of life (51.06 per cent) in males (70.21 per cent), allergic rhinitis (100 per cent) and nasal polyposis (100 per cent). Nasal obstruction (100 per cent), nasal discharge (89.36 per cent), postnasal drip (89.36 per cent), and unilateral nasal and paranasal sinus involvement (59.57 per cent) were significant features. Aspergillus (59.57 per cent) was the most common aetiological agent. Combined orbital and skull base erosion was seen in 30.04 per cent of cases, with male preponderance 6.8:1. Endoscopic sinus surgery was performed in all cases, and recurrent or residual disease was observed in 19.14 per cent.Conclusion:Allergic fungal rhinosinusitis is a disease of young, immunocompetent individual. Skull base and orbital erosion are seen in one-third of cases. Bone erosion is 6.8 times more common in males than females. Orbital erosion is 1.5 times more common than skull base erosion. Endoscopic surgical debridement and drainage combined with topical steroids leads to resolution of disease in the majority of cases, without resorting to systemic antifungal agents, craniotomy or dural resection.

Allergic fungal sinusitis (AFS) – earlier diagnosis and management

2005 ◽  
Vol 119 (11) ◽  
pp. 875-881 ◽  
Author(s):  
Neeraj Singh ◽  
N H Bhalodiya
Keyword(s):  
Antifungal Therapy ◽  
Statistical Significance ◽  
Sinus Surgery ◽  
Histological Evaluation ◽  
Intracranial Extension ◽  
Comprehensive Treatment ◽  
Fungal Sinusitis ◽  
Allergic Fungal Sinusitis ◽  
Surgical Specimen ◽  
Specimen Handling

Aim: To evaluate the criteria for diagnosing allergic fungal sinusitis and to maintain permanent drainage and ventilation, while preserving the integrity of mucosa. Methods: This is a prospective study of 251 patients with chronic rhinosinusitis with or without polyposis, of whom 199 were treated surgically. Mucus sample collection, nasal secretion culture, surgical specimen handling and histological evaluation of surgical specimens are described. The management included wide local endoscopic sinus debridement, adequate sinus aeration, post-operative use of steroids and antifungal therapy. Results: Fungal cultures of nasal secretions were positive in 201 (80.01 per cent) of 251 patients. Of the 199 surgical cases, fungal elements were found in 156 histological specimens (62.1 per cent). Allergic mucin was found in 182 patients (91.45 per cent). Nasal obstruction and proptosis were the commonest presentations. All pre-operative versus post-operative changes in AFS-associated complaints reached statistical significance of p < 0.001. The ethmoid sinus was commonly involved with adjacent lamina papyracea exhibiting demineralization in 26.6 per cent of cases. Intracranial extension was seen in 15 cases. Recurrence was noted in 11 cases. Conclusion: Comprehensive treatment with endoscopic sinus surgery, steroids and antifungal therapy is needed. AFS is readily recurrent. Long-term follow up is important.

scholarly journals Recurrence Pattern and Complication Rate of Allergic Fungal Sinusitis: A 10-Year Tertiary Center Experience

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Yazeed Alghonaim ◽  
Abdulrhman Alfayez ◽  
Riyadh Alhedaithy ◽  
Abdullah Alsheikh ◽  
Malak Almalki
Keyword(s):  
Chronic Rhinosinusitis ◽  
Recurrence Rate ◽  
Nasal Obstruction ◽  
Recurrent Disease ◽  
Disease Recurrence ◽  
Fungal Sinusitis ◽  
Allergic Fungal Sinusitis ◽  
Bilateral Disease ◽  
Fungal Rhinosinusitis ◽  
Allergic Fungal Rhinosinusitis

Background. Allergic fungal rhinosinusitis is a noninvasive form of highly recurrent chronic rhinosinusitis. Despite the advancement in medical and surgical strategies, recurrence in AFRS in general poses another challenging problem with reported incidence that eventually can reach more than 60%. Recognition and understanding the pattern of disease recurrence will lead to greater understanding of the disease response in our population. Method. A retrospective cohort study was performed in King Abdulaziz Medical City in Riyadh, Saudi Arabia. All patients diagnosed with chronic rhinosinusitis and underwent functional endoscopic sinus surgery from the period of January 2006 to December 2016 were reviewed. Results. 28 patients were found to have AFRS based on clinical, radiological, and microscopic examination suggestive of allergic fungal rhinosinusitis. Among these patients, 53% of them were female and 46% were male. The age ranged from 13 to 55 years, with a mean age of 31.57 years. 28.57% of the patients presented with recurrent allergic fungal sinusitis. The duration between the surgery and symptoms recurrence was around one year. Male and female patients had similar recurrence rate (50%). At first visit, 95% of the patients with nonrecurrent disease presented with nasal obstruction compared to 87.5% of the patients with recurrent disease. On the other hand, patients with recurrent disease had more nasal discharge (87.5%), postnasal drip (37.5%), facial pressure/pain (50%), headache (50%), nasal polyposis (87.5%), hypertrophy of inferior turbinate (37.5%), and proptosis (12.5%). Nasal obstruction (87.5%) and nasal polyps (87.5%) were the most common presenting symptoms for the disease recurrence. The pattern of disease recurrence in the previously unilateral disease was 18% ipsilateral and 27% bilateral. For the patients who had bilateral disease formerly, 17% (n = 3) of them had recurrent bilateral disease. Conclusion. Allergic fungal rhinosinusitis is a distinct clinical entity. A high recurrence rate is a pathognomonic feature of the disease, despite all the development in medical and surgical trials. This study demonstrated that recurrence rate is lower in our population. However, more studies with a greater number of patients are needed in the future to clearly recognize the pattern of recurrence in patients with AFRS.

scholarly journals Effect of functional endoscopic sinus surgery on the symptom profile in chronic rhinosinusitis cases

2020 ◽  
Vol 6 (2) ◽  
pp. 375
Author(s):  
G. Syam Manohar ◽  
Khan Majid Jabbar
Keyword(s):  
Quality Of Life ◽  
Chronic Rhinosinusitis ◽  
Nasal Obstruction ◽  
Endoscopic Sinus Surgery ◽  
Facial Pain ◽  
Functional Endoscopic Sinus Surgery ◽  
Sinus Surgery ◽  
Nasal Discharge ◽  
Symptom Profile

<p class="abstract"><strong>Background:</strong> Chronic rhinosinusitis (CRS) is a common chronic disease, that have considerable impact on quality of life, functional and emotional impairments of affected beings. Post-surgical improvement of quality of life indicates the surgical success. Functional endoscopic sinus surgery (FESS) is the dominating surgical procedure for CRS. This study was designed to assess the symptom profile of patient before and after surgery and the complications after FESS in the post-operative period.</p><p class="abstract"><strong>Methods:</strong> A total of 50 cases attending ENT outpatient department with clinical features and investigations suggestive of chronic sinusitis with infective pathology were randomly considered for this study. Cases were assessed for CRS symptoms pre and post operatively using grading symptoms.  </p><p class="abstract"><strong>Results:</strong> Common major symptom was nasal obstruction (93.3%, N=28) followed by post nasal drip (83.33%, N=25), purulent nasal discharge (76.66%, N=23), facial pain/pressure (66.66%, N=20) and hyposmia (60%, N=18). None of the patients reported fever and facial congestion or fullness. Post operatively, cases with nasal obstruction (92.8%), purulent nasal discharge (86.9%), facial pain or pressure (85%), headache (81.8%), post nasal drip (84%), ear pain or fullness or pressure (92.8%) and hyposmia (61.1%) showed improvement after FESS at the end of three follow-up.</p><p class="abstract"><strong>Conclusions:</strong> The most common symptom pre operatively was nasal obstruction which also responded best to FESS, along with all the other minor symptoms including headache. The results of this study confirm that FESS is an excellent method of treatment in patients with CRS refractory to medical treatment.</p>

Symptom Specific Outcomes of Endoscopic Sinus Surgery

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P81-P81
Author(s):  
Jastin L Antisdel ◽  
Raj Sindwani ◽  
Alexander C Chester
Keyword(s):  
Nasal Obstruction ◽  
Symptom Severity ◽  
Endoscopic Sinus Surgery ◽  
Facial Pain ◽  
Relative Effectiveness ◽  
Sinus Surgery ◽  
Nasal Discharge ◽  
Web Based ◽  
Relative Improvement ◽  
Severity Scores

Objective 1) Learn the relative effectiveness of endoscopic sinus surgery (ESS) regarding improving individual major chronic rhinosinusitis (CRS) symptoms and headache. 2) Be able to more effectively counsel patients undergoing ESS. Methods A literature search of MEDLINE, EMBASE, Web of Science, Cochrane databases, and other Web-based sources from 1980–2008 was performed. Additional articles were identified by reviewing relevant bibliographies. Studies with more than 10 adult CRS patients that used symptom severity scores to analyze at least 4 major criteria (facial pressure, congestion, nasal obstruction, nasal discharge, and hyposmia/anosmia) or 3 major criteria as well as headache were included. 265 studies were identified and reviewed. 22 of these met inclusion criteria and their data were analyzed. After conversion of the symptom severity scores used in each study to a relative percent value, symptom categories were averaged, and compared in aggregate. Results This analysis included 1641 CRS patients (average of 74 pts/study). The patients were followed an average of 19.4 months (range, 1 week to 76 months) postoperatively. All 6 evaluated symptoms showed non-weighted, relative improvements in symptom scores. Overall, symptoms improved synchronously with a relative improvement over preoperative levels ranging from 27% to 36%. ESS provided the greatest relief from nasal obstruction (relative improvement of 36%), which was a significantly larger change than with facial pain (p<0.034) or nasal discharge (p<0.034). Conclusions The relative improvement in major CRS symptoms and headache after surgery is similar. Nasal obstruction improves slightly more than facial pain and nasal discharge.

scholarly journals Allergic fungal rhinosinusitis: a clinical study in Srikakulam

2018 ◽  
Vol 5 (1) ◽  
pp. 149
Author(s):  
K. Jeevan Pradep ◽  
S. Ramesh ◽  
Hareesh .
Keyword(s):  
Endoscopic Sinus Surgery ◽  
Histopathological Examination ◽  
Fungal Growth ◽  
Functional Endoscopic Sinus Surgery ◽  
Antifungal Treatment ◽  
Sinus Surgery ◽  
Tropical Country ◽  
Fungal Rhinosinusitis ◽  
Allergic Fungal Rhinosinusitis ◽  
Management Protocol

<p class="abstract"><strong>Background:</strong> Allergic fungal rhinosinusitis is one of the differential diagnoses for chronic bacterial rhinosinusitis. Recognition and understanding of this unique disease will lead to efficient diagnosis and treatment of this curable process. India being a tropical country, provides an apt environment for fungal growth, the clinical diagnosis of Allergic fungal rhinosinusitis should not be missed and should be thoroughly investigated and managed to prevent recurrence. The objective of the study was to verify the management protocol for allergic fungal rhinosinusitis, after surgical clearance with functional endoscopic sinus surgery and postoperative histopathological examination and to see the efficacy of steroid and antifungal treatment</p><p class="abstract"><strong>Methods:</strong> A one year prospective study was considered with 28 patients from July 2016 to July 2017. Clinically suspected cases of rhinosinusitis depending upon their clinical presentation were subjected to nasal endoscopy, radiological examination and functional endoscopic sinus surgery. Postoperative histopathological examination was performed. Patients were followed up after giving steroid and antifungal treatment.  </p><p class="abstract"><strong>Results:</strong> 28 cases were non-invasive. <em>Aspergillus</em> was found to be the most common isolate. The criteria responsible for good prognosis of allergic fungal rhinosinusitis management were mainly found to be functional endoscopic sinus surgery followed by topical corticosteroid therapy.</p><p class="abstract"><strong>Conclusions:</strong> Allergic fungal rhinosinusitis is a disease entity on the rise. Prompt diagnosis and intervention prevents recurrence and complications.</p>

TO EVALUATE THE RESULTS OF FUNCTIONAL ENDOSCOPIC SINUS SURGERY TO PATIENTS SUFFERING FROM CHRONIC SINUSITIS WITH SPHENOID SINUSITIS

2017 ◽  
pp. 114-121
Author(s):  
Xuan Trung Ho ◽  
Van Dung Phan ◽  
Tu The Nguyen ◽  
Thanh Thai Le
Keyword(s):  
Ct Scan ◽  
Nasal Obstruction ◽  
Endoscopic Sinus Surgery ◽  
Chronic Sinusitis ◽  
Functional Endoscopic Sinus Surgery ◽  
University Hospital ◽  
Sinus Surgery ◽  
Nasal Discharge ◽  
Sphenoid Sinusitis ◽  
Grade Iii

Objective: To evaluate the features and CT scan of chronic sinusitis with sphenoid sinusitis. To evaluate the results in patients undergoing Functional Endoscopic Sinus Surgery. Subjects and Method: a prospective descriptive study with intervention was designed for 34 patients at Hue Pharmacy and Medicine University hospital and Da nang hospital. Results: almost all patients presented nasal discharge, headache and nasal obstruction. Endoscopic assessment: grade III-IV 82,3%, grade I-II 17,7%. CT scan assessment: grade III-IV 85,2%, grade I-II 14,8%. 34 patients were followed up after 6 months. Conclusions: almost common presenting complaints were nasal discharge, headache and nasal obstruction. Majority of patients were better in symptoms, endoscopic and CT scan features. Key words: sphenoid sinusitis, chronic sinusitis, endoscopic sinus surgery

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