scholarly journals Audiological manifestations in patients of upper airway allergy

2019 ◽  
Vol 5 (6) ◽  
pp. 1451
Author(s):  
Gurbinder Singh Sekhon ◽  
Rohit Verma ◽  
Manish Munjal ◽  
Hemant Chopra
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Inner Ear ◽  
Otoacoustic Emissions ◽  
Upper Airway ◽  
Sensorineural Hearing ◽  
Study Group ◽  
Auditory Brain Stem Response ◽  
Distortion Product ◽  
Significant Difference

<p class="abstract"><strong>Background:</strong> The pathophysiology of involvement of inner ear in patients of upper airway allergy is poorly understood. The endolymphatic sac may be the likely seat of involvement in these patients as it can process antigens and produce its own local immune response. The aim of study was to assess the audiological profile of these patients.</p><p class="abstract"><strong>Methods:</strong> 53 patients of upper airway allergy (33 females and 20 males with mean age 25.77 years) and 20 control subjects (9 females and 11 males with mean age of 35.65 years) underwent haematological and audiological assessment.  </p><p class="abstract"><strong>Results:</strong> The study group had sensorineural hearing loss at 4000 and 8000 Hz frequencies. Abnormal distortion product otoacoustic emissions (DPOAEs) were noted in the study group as compared with the controls. On auditory brain stem response testing, no statistically significant difference was noted in the absolute latencies of waves I, III and V between study and control groups. Also no statistically significant difference was noted in the wave I-III and wave I-V inter peak latencies between the two groups.</p><p class="abstract"><strong>Conclusions:</strong> We found higher prevalence of high frequency sensorineural hearing loss and abnormalities of DPOAEs in patients having upper airway allergy. The likely seat of damage appears to be the inner ear as evidenced by abnormalities of DPOAEs. However the exact pathophysiology of inner ear damage in patients of upper airway allergy is poorly understood and needs further research.</p>

scholarly journals Exogenous IL-4-Expressing Bone Marrow Mesenchymal Stem Cells for the Treatment of Autoimmune Sensorineural Hearing Loss in a Guinea Pig Model

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Chang-qiang Tan ◽  
Xia Gao ◽  
Lang Guo ◽  
He Huang
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Inner Ear ◽  
Sensorineural Hearing ◽  
Scala Tympani ◽  
Auditory Brain Stem Response ◽  
Marrow Mesenchymal Stem Cells

Bone marrow mesenchymal stem cells (BMSCs) expressing recombinant IL-4 have the potential to remediate inflammatory diseases. We thus investigated whether BMSCs expressing exogenous IL-4 could alleviate autoimmune sensorineural hearing loss. BMSCs isolated from guinea pigs were transfected with recombinant lentivirus expressing IL-4. A total of 33 animals were divided into three groups. Group A received scala tympani injection of IL-4-expressing BMSCs, and Group B received control vector-expressing BMSCs, and Group C received phosphate-buffered saline. The distribution of implanted BMSCs in the inner ears was assessed by immunohistochemistry and fluorescence microscopy. Auditory brain-stem response (ABR) was monitored to evaluate the auditory changes. Following BMSCs transplantation, the threshold levels of ABR wave III decreased in Groups A and B and significant differences were observed between these two groupsP<0.05. Transplanted BMSCs distributed in the scala tympani and scala vestibuli. In some ears with hearing loss, there was a decrease in the number of spiral ganglion cells and varying degrees of endolymphatic hydrops or floccule. Following transplantation, the lentivirus-infected BMSCs migrated to the inner ear and produced IL-4. Our results demonstrate that, upon transplantation, BMSCs and BMSCs expressing recombinant IL-4 have the ability to remediate the inflammatory injury in autoimmune inner ear diseases.

Changes in Otoacoustic Emissions and Auditory Brain Stem Response after C/s-Platinum Exposure in Gerbils

1997 ◽  
Vol 116 (6) ◽  
pp. 585-592 ◽  
Author(s):  
Kathleen C. Y. Sie ◽  
Susan J. Norton
Keyword(s):  
Hearing Loss ◽  
Brain Stem ◽  
Otoacoustic Emissions ◽  
Outer Hair Cell ◽  
Outer Hair Cells ◽  
Distortion Product Otoacoustic Emissions ◽  
Auditory Brain Stem Response ◽  
Distortion Product ◽  
Auditory Brain Stem ◽  
Significant Difference

Ototoxicity associated with cis-platinum administration commonly presents as hearing loss and tinnitus. The hearing loss is usually an irreversible, high-frequency sensorineural loss. Histologic studies in humans and animals suggest that the outer hair cells (OHCs) are most susceptible to cis-platinum. Evoked otoacoustic emissions (EOAE), as a measure of outer hair cell function, are potentially useful in following ototoxic insults involving OHCs. Distortion-product otoacoustic emissions (DPOAE) test frequency-specific regions of the cochlea and therefore may be particularly well suited for monitoring ototoxic injuries. We measured distortion product otoacoustic emissions, at f2 = 2, 4, 6, 8, 10, and 12 kHz, in gerbils after a single large dose of cis-platinum. Animals treated with saline served as controls. The findings were compared to auditory brain stem evoked response (ABR) thresholds, using tone pips of the same frequencies. The DPOAE and ABR thresholds were measured before treatment and again 2, 5, and 14 days after drug administration. The changes in DPOAE were compared with the changes in ABR. No treatment effect was noted in the 2-day group. Animals treated with c/s-platinum demonstrated significant elevation of DPOAE and ABR thresholds compared with control animals at 5 and 14 days. There was no significant difference between the threshold changes in the 5-and 14-day groups.

A Hearing Screening Pilot Study With Students With Significant Cognitive Disabilities

2020 ◽  
Vol 51 (2) ◽  
pp. 494-503
Author(s):  
Nancy Quick ◽  
Jackson Roush ◽  
Karen Erickson ◽  
Martha Mundy
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Doctoral Students ◽  
Otoacoustic Emissions ◽  
Cognitive Disabilities ◽  
Sensorineural Hearing ◽  
Significant Disabilities ◽  
Significant Cognitive Disabilities ◽  
Distortion Product ◽  
School Based

Purpose Many children with severe intellectual and developmental disabilities are at a higher risk for hearing loss than their peers who are typically developing. Unfortunately, they do not consistently participate in routine school-based hearing screenings. The current study investigated the feasibility of increasing their participation using an otoacoustic emissions protocol and documented results relative to student educational profiles. Method A total of 43 students with significant cognitive disabilities enrolled at a public school exclusively serving this population participated in the study. All but 9, who were excluded because of known hearing loss, were screened by a licensed audiologist assisted by audiology doctoral students. The protocol included otoscopy, tympanometry, distortion product otoacoustic emissions (DPOAEs), and teacher surveys. Results DPOAE screening was attempted on 33 students without previously diagnosed hearing loss and successfully completed for 26 (78.8%). Two students (4.6%) with absent otoacoustic emissions and normal tympanograms were referred for further assessment due to concerns about possible sensorineural hearing loss in one or both ears, and 10 (23.3%) had abnormal tympanograms in one or both ears. Conclusions Considering the high risk of sensorineural hearing loss for children with significant disabilities, it is important for them to be included in school hearing screenings. The results of this study demonstrate the feasibility of using DPOAEs for school-based hearing screenings with this population with an interprofessional team of licensed audiologists, educators, and speech-language pathologists. The results further suggest that students with significant disabilities and hearing loss may be unidentified and underserved. Given the complex needs of this population, an interprofessional practice model for hearing screenings and intervention services is recommended.

Spontaneous Recovery of Sudden Sensorineural Hearing Loss: Possible Association with Autoimmune Disorders

2006 ◽  
Vol 17 (07) ◽  
pp. 498-505 ◽  
Author(s):  
Jeffrey J. DiGiovanni ◽  
Padmaja Nair
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Otoacoustic Emissions ◽  
White Male ◽  
Pure Tone Audiometry ◽  
Normal Hearing ◽  
Sensorineural Hearing ◽  
Residual Effects ◽  
Distortion Product ◽  
The Right

A 46-year-old white male diagnosed with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) was seen for audiological testing 15 minutes following a sudden onset hearing loss in the right ear. The test battery included pure-tone audiometry, word-recognition testing, speech-recognition threshold (SRT) testing, immittance testing, and distortion-product otoacoustic emissions (DPOAE) testing. Testing revealed a sensorineural hearing loss in the right ear. Shortly after testing, the patient indicated that his condition had improved. Testing was repeated, and the second round of tests revealed normal hearing in both ears. Four days later, a follow-up test again indicated normal hearing in both ears. Possible connections of this brief occurrence of idiopathic hearing loss with the patient's medical conditions are discussed. Specifically, symptoms were consistent with a transient ischemic attack (TIA) affecting his right cochlea in the stria vascularis region, resulting in a temporary, sensorineural hearing loss. No residual effects were observed clinically.

Hearing status in patients with rheumatoid arthritis

2017 ◽  
Vol 131 (10) ◽  
pp. 895-899 ◽  
Author(s):  
A Ahmadzadeh ◽  
M Daraei ◽  
M Jalessi ◽  
A A Peyvandi ◽  
E Amini ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Otoacoustic Emissions ◽  
Bone Conduction ◽  
Pure Tone Audiometry ◽  
Sensorineural Hearing ◽  
Speech Discrimination ◽  
Distortion Product ◽  
Acoustic Reflexes

AbstractObjective:Rheumatoid arthritis is thought to induce conductive hearing loss and/or sensorineural hearing loss. This study evaluated the function of the middle ear and cochlea, and the related factors.Methods:Pure tone audiometry, speech reception thresholds, speech discrimination scores, tympanometry, acoustic reflexes, and distortion product otoacoustic emissions were assessed in rheumatoid arthritis patients and healthy volunteers.Results:Pure tone audiometry results revealed a higher bone conduction threshold in the rheumatoid arthritis group, but there was no significant difference when evaluated according to the sensorineural hearing loss definition. Distortion product otoacoustic emissions related prevalence of conductive or mixed hearing loss, tympanometry values, acoustic reflexes, and speech discrimination scores were not significantly different between the two groups. Sensorineural hearing loss was significantly more prevalent in patients who used azathioprine, cyclosporine and etanercept.Conclusion:Higher bone conduction thresholds in some frequencies were detected in rheumatoid arthritis patients that were not clinically significant. Sensorineural hearing loss is significantly more prevalent in refractory rheumatoid arthritis patients.

Efficacy of intratympanic methylprednisolone acetate in treatment of drill-induced sensorineural hearing loss in guinea pigs

2005 ◽  
Vol 119 (1) ◽  
pp. 2-7 ◽  
Author(s):  
Diaa M El-Hennawi ◽  
Mohamed H Badr El-Deen ◽  
Ashraf S Abou-Halawa ◽  
Hani S Nadeem ◽  
Mohamed R Ahmed
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Inner Ear ◽  
Guinea Pigs ◽  
Outer Hair Cells ◽  
Sensorineural Hearing ◽  
Control Group ◽  
Methylprednisolone Acetate ◽  
Distortion Product ◽  
Sem Morphology

Intratympanic steroids offer direct access to the inner ear with high concentration and without systemic effects. In this study, the efficacy of intratympanic methylprednisolone acetate (IT-MPA) was evaluated in a guinea-pig model of drill-induced inner ear trauma.Twenty-five guinea pigs were divided into a control group to document the baseline distortion product otoacoustic emissions (DPOAEs) and the normal scanning electron microscopic (SEM) morphology of the inner ear. The animals in the study group were subdivided into a steroid-only group (S), a trauma-only group(T), a trauma-plus-time group (TT), and a trauma-plus-steroid (TS) group.IT-MPA was found to have no damaging effect on the inner ear. Twelve days after trauma, there was spontaneous although incomplete recovery of the DPOAEs amplitudes and SEM morphology with scar tissue replacing lost outer hair cells. Statistically higher DPOAEs amplitudes (p < 0.05) were recorded in the TS group that had nearly normal SEM morphology compared to the TT group. The authors conclude that IT-MPA significantly improves drill-induced sensorineural hearing loss and inner ear morphological changes in guinea pigs.

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