scholarly journals Cyclin D1 expression in Peripheral T-Cell Lymphoma: A report of 2 cases

2021 ◽  
Vol 6 (4) ◽  
pp. 279-282
Author(s):  
Shweta P Rathi ◽  
Vinita Pant ◽  
Jay Mehta
Keyword(s):  
T Cell ◽  
Cyclin D1 ◽  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Plasma Cell Myeloma ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Peripheral T Cell Lymphoma ◽  
Mantle Cell

: Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of non-Hodgkin's lymphomas (NHL), characterized by poor outcome, accounting approximately for 10%-15% of all non-Hodgkin lymphomas in the western countries, and with a higher prevalence in Asia. Cyclin D1 immunoreactivity is characteristically seen in mantle cell lymphoma. It is also observed in hairy cell leukemia, plasma cell myeloma and a proportion of diffuse large B-cell lymphomas, however its expression in peripheral T-cell lymphoma is rarely recorded. : We report two cases of peripheral T-cell lymphoma not otherwise specified with heterogeneous nuclear Cyclin D1 immunohistochemical overexpression, due to gene copy gain, a phenomenon similar to that observed in Mantle Cell Lymphoma.: Cyclin D1 expression can be seen in PTCLs, besides mantle cell lymphoma, hairy cell leukemia and plasma cell myeloma and underline the importance of molecular biology integration tests as a diagnostic tool to escape the pitfall.

scholarly journals The simultaneous presentation of peripheral T-cell lymphoma and hairy cell leukemia

Cancer ◽  
1987 ◽  
Vol 60 (7) ◽  
pp. 1537-1544 ◽  
Author(s):  
Emer Lawlor ◽  
D. Sean O'Briain ◽  
Theresa Finn ◽  
Ronan Ward ◽  
Francisca M. Rogers ◽  
...  
Keyword(s):  
T Cell ◽  
Hairy Cell Leukemia ◽  
Cell Lymphoma ◽  
Simultaneous Presentation ◽  
T Cell Lymphoma ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Peripheral T Cell Lymphoma

scholarly journals Immunohistochemical Detection of Cyclin D1 Using Optimized Conditions Is Highly Specific for Mantle Cell Lymphoma and Hairy Cell Leukemia

2000 ◽  
Vol 13 (12) ◽  
pp. 1308-1314 ◽  
Author(s):  
Roberto N Miranda ◽  
Robert C Briggs ◽  
Marsha C Kinney ◽  
Pat A Veno ◽  
Richard D Hammer ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Mantle Cell Lymphoma ◽  
Hairy Cell Leukemia ◽  
Cell Lymphoma ◽  
Immunohistochemical Detection ◽  
Hairy Cell ◽  
Cell Leukemia ◽  
Mantle Cell ◽  
Optimized Conditions

Cutaneous mantle cell lymphoma histomorphologically mimicking subcutaneous panniculitis‐like T‐cell lymphoma: Case report

2019 ◽  
Vol 46 (7) ◽  
pp. 538-541 ◽  
Author(s):  
Caroline Laggis ◽  
Rodney Miles ◽  
Deborah M. Stephens ◽  
Keith Duffy ◽  
Anneli Bowen ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
Mantle Cell Lymphoma ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Mantle Cell

scholarly journals Peripheral T-cell Lymphoma with Cyclin D1 overexpression: a case report

2012 ◽  
Vol 7 (1) ◽  
pp. 79 ◽  
Author(s):  
Gabriella Aquino ◽  
Renato Franco ◽  
Fioravante Ronconi ◽  
Annamaria Anniciello ◽  
Luigi Russo ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
Cyclin D1 ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Peripheral T Cell Lymphoma

scholarly journals Co-existence of cutaneous T-cell lymphoma and B hairy cell leukemia

2000 ◽  
Vol 64 (3) ◽  
pp. 197-202 ◽  
Author(s):  
Rossella Paolini ◽  
Alessandro Poletti ◽  
Emilio Ramazzina ◽  
Chiara Menin ◽  
Maria Santacatterina ◽  
...  
Keyword(s):  
T Cell ◽  
Hairy Cell Leukemia ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Hairy Cell ◽  
Cell Leukemia

scholarly journals Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma

Blood ◽  
2010 ◽  
Vol 115 (5) ◽  
pp. 1026-1036 ◽  
Author(s):  
Javeed Iqbal ◽  
Dennis D. Weisenburger ◽  
Timothy C. Greiner ◽  
Julie M. Vose ◽  
Timothy McKeithan ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
High Expression ◽  
Molecular Signature ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Peripheral T Cell Lymphoma ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Adult T Cell Leukemia

Abstract Peripheral T-cell lymphoma (PTCL) is often challenging to diagnose and classify. Gene expression profiling was performed on 144 cases of PTCL and natural killer cell lymphoma and robust molecular classifiers were constructed for angioimmunoblastic T-cell lymphoma (AITL), anaplastic lymphoma kinase-positive (ALK+) anaplastic large-cell lymphoma (ALCL), and adult T-cell leukemia/lymphoma. PTCL-unclassifiable was molecularly heterogeneous, but we were able to identify a molecular subgroup with features of cytotoxic T lymphocytes and a poor survival compared with the remaining PTCL–not otherwise specified cases. Many of the pathologic features and substantial components of the molecular signature of AITL are contributed by the follicular dendritic cells, B-cell, and other stromal components. The expression of Th17-associated molecules in ALK+ ALCL was noted and may represent aberrant activation of Th17-cell differentiation by abnormal cytokine secretion. Adult T-cell leukemia/lymphoma has a homogeneous molecular signature demonstrating high expression of human T-lymphotropic virus type 1–induced genes. These classifiers reflect the biology of the tumor cells as well as their microenvironment. We also constructed a molecular prognosticator for AITL that appears to be largely related to the microenvironmental signature, and the high expression of 2 immunosuppressive signatures are associated with poor outcome. Oncogenic pathways and tumor-host interactions also were identified, and these findings may lead to better therapies and outcome in the future.

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