scholarly journals A study on association of serum uric acid and blood pressure in hypertensives at a tertiary care centre

2021 ◽  
Vol 8 (4) ◽  
pp. 264-268
Author(s):  
K Ranjith Babu ◽  
Malika Noorjehan Samozai ◽  
Rajashree Devarapalli
Keyword(s):  
Blood Pressure ◽  
Uric Acid ◽  
Correlation Coefficient ◽  
Serum Uric Acid ◽  
High Blood Pressure ◽  
Pearson’S Correlation Coefficient ◽  
History Of ◽  
Pearson's Correlation ◽  
The Mean ◽  
Pearson's Correlation Coefficient

Hypertension(HTN) is the most common and significant cardiovascular disease because of its prevalence and severity of the damage to the mankind globally. Hyperuricemia, a condition of increased levels of Serum Uric acid (UA) has been proposed to have an association with hypertension in various studies. In certain studies, serum uric acid levels has been found to be an independent predictor for developing hypertension. On the basis of the above observations, we have proposed to the present study to compare the relationship between serum UA and hypertension in a single cohort with adjustment of all possible confounding factors.A total of 245 subjects were enrolled in this study during a regular routine health checkup. All subjects were informed about the study aims Individuals having a known history of gout and cardiac or severe renal diseases and patients who are already under medication for anti-hyperuricemic were excluded from the study. General information like Name, Age, Sex, Occupation, Address along with history of any drug intake and anthropometric indices - body weight (BW), body height (BH), hip circumference (HC), waist circumference (WC), and lifestyle information have been obtained. The data has been arranged in tables with mean ± SD for further analysis. The data is analyzed using IBM SPSS version 23. The difference between the groups for baseline variables was done by independent sample t-test (two-tailed). Pearson’s correlation coefficient test was performed to assess the interrelationships between baseline variables and SUA concentrations. The differences for the variables among the groups was determined by using One-way ANOVA.Of the 245 subjects, mean age of the participants was 42.4 ± 8.4 years (range 18–70 years). There was no significant difference in the mean levels of Height, Weight and BMI between the two groups. Mean levels of WC, HC were significantly different between two group (p < 0.05) subjects. The mean levels of SBP and DBP were also significantly more in the hypertensive subjects (p < 0.001). In Pearson’s correlation coefficient test, SUA levels were significantly related with SBP and DBP. In this study, we have observed comparatively a stronger relationship for SUA concentration with hypertension and prehypertension in the participants. The extended mechanism for the effect of SUA on hypertension is yet to be elucidated. There are some hypotheses partly explain the association between SUA and high blood pressure. One of the possible mechanism might be uric acid deposition on the blood vessels walls activates the renin-angiotensin system, suppress the liberate of carbon monoxide, enhance inflammation, and leads to vasoconstriction on later stage, which consequently leads to hyperplasia and incidence of hypertension. Another possibility involving oxidative stress and endothelial dysfunction associated with high SUA levels may contribute to high blood pressure.

Glottic Closing Force Versus Laryngeal Adductory Pressure in the Canine Larynx

2016 ◽  
Vol 126 (3) ◽  
pp. 173-178 ◽  
Author(s):  
Randal C. Paniello ◽  
Neel K. Bhatt
Keyword(s):  
Correlation Coefficient ◽  
Physical Property ◽  
Vocal Folds ◽  
Pearson’S Correlation ◽  
Pearson’S Correlation Coefficient ◽  
Vocal Process ◽  
Closing Force ◽  
Pearson's Correlation ◽  
The Mean ◽  
Pearson's Correlation Coefficient

Introduction: The strength of glottic closure with recurrent laryngeal nerve (RLN) stimulation has been indirectly measured experimentally by determining the squeezing pressure on a balloon inserted between the vocal folds, termed laryngeal adductory pressure (LAP). In this study, we sought to measure glottic closing force (GCF) directly and compare these results to LAP measures obtained with identical stimulation parameters. Methods: In canines, a method for measuring GCF was developed in which a suture was looped through a lateral thyrotomy hole, around the vocal process and back, then attached to a force gauge. The RLN was maximally stimulated and GCF recorded. The LAP was then measured as previously described, using the same stimuli. This process was repeated at 9 stimulation frequencies in 10-Hz intervals from 20 to 100 Hz. The GCF and LAP were compared using Pearson’s correlation coefficient (PCC). Results: Both sides were measured in 16 dogs, resulting in 32 data sets. The LAP measures were obtained at all frequencies, while GCF was obtained in 246 of 288 (85.4%) attempts. The maximum GCF for each dog typically occurred at 80 to 100 Hz and averaged 0.287 ± 0.106 newtons. Plotting GCF versus LAP for each hemilaryngeal preparation, the mean PCC was 0.932 ± .042 (range, 0.802-0.987). The mean PCC did not differ between control (n = 26) and postoperative (n = 6) hemilarynges. Conclusion: This method for measuring GCF appears valid. The high Pearson’s correlation coefficient indicates strong covariance between GCF and LAP, demonstrating that they are both measures of the same physical property. The LAP is easier to perform and more consistently obtained.

scholarly journals Evaluation of the New Digital Goldmann Applanation Tonometer for Measuring Intraocular Pressure

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
Yuta Sakaue ◽  
Jun Ueda ◽  
Masaaki Seki ◽  
Takayuki Tanaka ◽  
Tetsuya Togano ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Correlation Coefficient ◽  
Pearson’S Correlation ◽  
Pearson’S Correlation Coefficient ◽  
Goldmann Applanation Tonometer ◽  
Applanation Tonometer ◽  
Pearson's Correlation ◽  
The Mean ◽  
The Difference ◽  
Pearson's Correlation Coefficient

Purpose. To compare a new digital Goldmann applanation tonometer (dGAT) that measures intraocular pressure (IOP) in 0.1 mmHg increments to a standard Goldmann applanation tonometer (sGAT).Methods. This study included 116 eyes of 60 subjects. A single examiner first measured IOP in triplicate using either sGAT or dGAT, which was randomly chosen. After a 5-minute interval, the next set of three consecutive IOP was measured using the other GAT.Results. The mean IOP measured with sGAT was 16.27 ± 6.68 mmHg and 16.35 ± 6.69 mmHg with dGAT. Pearson’s correlation coefficient was 0.998 (P<0.01). The subjects were divided into three groups based on the mean IOP: IOP < 14 mmHg, 14–20 mmHg, or >20 mmHg. The Pearson’s correlation coefficient within each group was 0.935, 0.972, and 0.997 (P<0.01), respectively. The difference within the three consecutive IOP measurements (maximum–minimum) for dGAT (0.72 ± 0.34 mmHg) was significantly smaller than those with sGAT (0.92 ± 0.42 mmHg,P<0.01). Even in patients with equal IOP (zero left-right difference) with sGAT (n=30), dGAT detected IOP differences between the left and right eyes (0.47 ± 0.31 mmHg).Conclusion. Compared to sGAT, dGAT measurements are highly reproducible and less variable.

scholarly journals The Association Between Severity of Dysmenorrhea and Social Support among Female Students of Ilam University of Medical Sciences

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Mahsa Mashreghi ◽  
Zainab Suhrabi ◽  
Parand Soliemanifard ◽  
Sedigheh Farzi ◽  
Safoura Taheri
Keyword(s):  
Social Support ◽  
Correlation Coefficient ◽  
Female Students ◽  
Inverse Association ◽  
Medical Sciences ◽  
Pearson’S Correlation ◽  
Pearson’S Correlation Coefficient ◽  
Pearson's Correlation ◽  
The Mean ◽  
Pearson's Correlation Coefficient

Background: Dysmenorrhea or painful menstruation is the most common periodic pain in women, which includes primary and secondary types. One of the possible factors affecting the severity of dysmenorrhea is the presence or absence of social support. Objectives: Due to the high prevalence of dysmenorrhea and its undesirable consequences on the quality of personal, social, and academic life of students, this study aimed to evaluate the association between severity of dysmenorrhea and social support among female students of Ilam University of Medical Sciences, Iran. Methods: Using purposeful sampling method, this cross-sectional and descriptive-analytical study was conducted on 286 female students of Ilam University of Medical Sciences (age range: 18 - 28 years) in 2018. Data collection tools included demographic information form, Visual Analogue Scale (VAS) to determine pain severity, and standardized Social Support Questionnaire (SSQ) to assess social support. Descriptive statistics (frequency and mean) and analytical statistics (Pearson’s correlation coefficient) were used for data analysis in SPSS software version 16. Results: The mean age of the samples was 21.62 ± 2.10 years, and the mean age of menarche was 13.57 ±1.33 years. The prevalence of primary dysmenorrhea was 86% among the samples, with 8% of them having low social support, 39.2% moderate social support, and 52.8% high social support. There was a significant association between social support and severity of dysmenorrhea so that Pearson’s correlation coefficient showed an inverse association between the two variables (r = -0.187, P = 0.002). Conclusions: The inverse association between the severity of dysmenorrhea and the level of social support highlighted the need for planning to create and enhance social support by family and community and reduce the effects that dysmenorrhea can have on physical, mental, and social health of individuals.

scholarly journals Case Study of Anaerobic Digestion Process Stability Detected by Dissolved Hydrogen Concentration

Processes ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 106
Author(s):  
Daniela Platošová ◽  
Jiří Rusín ◽  
Jan Platoš ◽  
Kateřina Smutná ◽  
Roman Buryjan
Keyword(s):  
Anaerobic Digestion ◽  
Correlation Coefficient ◽  
Hydrogen Concentration ◽  
Pearson’S Correlation ◽  
Pearson’S Correlation Coefficient ◽  
Digestion Process ◽  
Short Service Life ◽  
Pearson's Correlation ◽  
Dissolved Hydrogen ◽  
Pearson's Correlation Coefficient

The paper presents the results of a laboratory experiment of mesophilic single-stage anaerobic digestion performed to verify the possibility of early detection of process instability and reactor overload by evaluating the course of dissolved hydrogen concentration of the main intermediate. The digestion process was run in a Terrafors IS rotary drum bioreactor for 230 days. The substrate dosed on weekdays was food leftovers from the university canteen. At an average temperature of 37 °C, an organic loading of volatiles of 0.858 kg m−3 day−1 and a theoretical retention time of 259 days, biogas production of 0.617 Nm3 kg VS−1 was achieved with a CH4 content of 51.7 vol. %. The values of the established FOS/TAC stability indicator ranged from 0.26 to 11.4. The highest value was reached when the reactor was overloaded. The dissolved hydrogen concentration measured by the amperometric microsensor ranged from 0.039–0.425 mg dm−3. Data were statistically processed using Pearson’s correlation coefficient. The correlation of the hydrogen concentration with other parameters such as the concentration of organic acids was evaluated. The value of Pearson’s correlation coefficient was 0.331 and corresponded to a p-value of 0. The results confirmed a very low limit of the hydrogen concentration at which the microbial culture, especially methanogens, was already overloaded. The amperometric microsensor proved to be rather unsuitable for operational applications due to insufficient sensitivity and short service life. The newly designed ratio of dissolved hydrogen concentration to neutralizing capacity was tested but did not work significantly better than the established FOS/TAC stability indicator.

Italian version of the cornell musculoskeletal discomfort questionnaire (CMDQ-I): Translation, cultural adaptation and validation

Work ◽  
2021 ◽  
pp. 1-7
Author(s):  
F. Magnifica ◽  
F. Colagrossi ◽  
A. Aloisi ◽  
S. Politi ◽  
A. Peretti ◽  
...  
Keyword(s):  
Correlation Coefficient ◽  
Cultural Adaptation ◽  
Italian Version ◽  
Cronbach’S Alpha ◽  
Musculoskeletal Discomfort ◽  
Pearson’S Correlation ◽  
Pearson’S Correlation Coefficient ◽  
Cronbach's Alpha ◽  
Pearson's Correlation ◽  
Pearson's Correlation Coefficient

BACKGROUND: Almost 25%of workers in the European Union suffer from back pain, and 23%complain of muscle pain. Sixty-two percent of workers carry out repetitive operations with their hands or arms, 46%work in painful or tired positions and 35%carry or handle loads. OBJECTIVE: This study aimed to translate, culturally adapt and validate the Italian version of the Cornell Musculoskeletal Discomfort Questionnaire (CMDQ-I). METHODS: Translation and cultural adaptation procedures followed international guidelines. Participants were recruited from among the personnel components of the Italian Air Force, who were between 18 and 65 years old. Cronbach’s alpha and the intraclass correlation coefficient (ICC) were calculated to assess internal consistency and stability, respectively. The CDMQ-I was administered together with the Visual Analogic Scale (VAS), and the validity was evaluated using Pearson’s correlation coefficient. RESULTS: All CDMQ-I items were either identical or similar in meaning to the original version’s items. The scale was administered twice with a retest after seven to 10 days to 66 participants. Cronbach’s alpha was higher than 0.761, and the ICC ranged between 0.737 and 0.952. Pearson’s correlation coefficient showed positive and significant correlations (p >  0.01). CONCLUSIONS: The study produced an Italian version of the CMDQ with good reliability and validity. This scale is a useful tool to investigate the frequency and intensity of musculoskeletal disorders in various categories of workers.

scholarly journals Suitable Docking Protocol for the Design of Novel Coumarin Derivatives with Selective MAO-B Effects

2021 ◽  
Vol 1 (1) ◽  
pp. 40-47
Author(s):  
Emilio Viktorov Mateev ◽  
Iva Valkova ◽  
Maya Georgieva ◽  
Alexander Zlatkov
Keyword(s):  
Correlation Coefficient ◽  
Scoring Functions ◽  
Pearson’S Correlation ◽  
Chain Flexibility ◽  
Pearson’S Correlation Coefficient ◽  
Pairwise Correlation ◽  
Mao B ◽  
Docking Protocol ◽  
Pearson's Correlation ◽  
Pearson's Correlation Coefficient

Recently, the application of molecular docking is drastically increasing due to the rapid growth of resolved crystallographic receptors with co-crystallized ligands. However, the inability of docking softwares to correctly score the occurred interactions between ligands and receptors is still a relevant issue. This study examined the Pearson’s correlation coefficient between the experimental monoamine oxidase-B (MAO-B) inhibitory activity of 44 novel coumarins and the obtained GOLD 5.3 docking scores. Subsequently, optimization of the docking protocol was carried out to achieve the best possible pairwise correlation. Numerous modifications in the docking settings such as alteration in the scoring functions, size of the grid space, presence of active waters, and side-chain flexibility were conducted. Furthermore, ensemble docking simulations into two superimposed complexes were performed. The model was validated with a test set. A significant Pearson’s correlation coefficient of 0.8217 was obtained for the latter. In the final stage of our work, we observed the major interactions between the top-scored ligands and the active site of 1S3B.

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