scholarly journals ANTIPHAGE ACTIVITY OF ASYMMETRICALLYSUBSTITUTED PYRIDYLPORPHYRINS

2013 ◽  
Vol 0 (3(23)) ◽  
pp. 94-103
Author(s):  
Н. С. Водзінська ◽  
Б. М. Галкін ◽  
С. В. Водзінський ◽  
Т. О. Філіпова
Keyword(s):  
1982 ◽  
Vol 13 (13) ◽  
Author(s):  
V. G. KHARCHENKO ◽  
N. I. KOZHEVNIKOVA ◽  
L. K. KULIKOVA ◽  
N. V. VORONINA
Keyword(s):  

1996 ◽  
Vol 32 (10) ◽  
pp. 1131-1135
Author(s):  
O. V. Fedotova ◽  
E. V. Lipatova ◽  
E. B. Kapitonova ◽  
P. V. Reshetov ◽  
O. P. Plotnikov ◽  
...  

2017 ◽  
Vol 12 (2) ◽  
pp. 109-117 ◽  
Author(s):  
Marzanna Łusiak-Szelachowska ◽  
Maciej Żaczek ◽  
Beata Weber-Dąbrowska ◽  
Ryszard Międzybrodzki ◽  
Sławomir Letkiewicz ◽  
...  

1961 ◽  
Vol 81 (1) ◽  
pp. 101-104 ◽  
Author(s):  
IN ASHESHOV ◽  
JJ GORDON

2021 ◽  
Author(s):  
Yunlin Wei ◽  
Chunting Zhang ◽  
Kunhao Qin ◽  
Xiaodan Zheng ◽  
Qian Luo ◽  
...  

Recent studies on preservation property in the field of materials science suggest that a newly synthesized material can retain the biological properties of the raw material. Still, further study is...


2020 ◽  
Vol 15 (9) ◽  
pp. 767-777
Author(s):  
Jhonatan M Ribeiro ◽  
Giovana N Pereira ◽  
Renata KT Kobayashi ◽  
Gerson Nakazato

Viruses are considered biological entities that possess a genome and can adapt to the environment of living organisms. Since they are obligate intracellular parasites, their cycle of replication can result in cell death, and consequently, some viruses are harmful to mammalian cells and can cause disease in humans. Therefore, the search for substances for the treatment of viral diseases can be accomplished through the use of bacteriophages as models for eukaryotic cell viruses. Thus, this review highlights the main studies identifying substances with antiphage activity in comparison assays involving phages and eukaryotic viruses, in order to explore the potential of these substances as antivirals. As a future perspective, this approach may help at the beginning of an Antiviral Age.


ChemInform ◽  
2010 ◽  
Vol 32 (52) ◽  
pp. no-no
Author(s):  
S. K. Klimenko ◽  
T. V. Stolbova ◽  
L. K. Kulikova ◽  
F. M. Shub
Keyword(s):  

1960 ◽  
Vol 5 (1) ◽  
pp. 46-49
Author(s):  
V. Bydžovský ◽  
A. Šlmek
Keyword(s):  

ChemInform ◽  
2010 ◽  
Vol 33 (1) ◽  
pp. no-no
Author(s):  
V. V. Sorokin ◽  
A. P. Kriven'ko ◽  
N. A. Vinogradova ◽  
O. P. Plotnikov
Keyword(s):  

2015 ◽  
Vol 81 (11) ◽  
pp. 3848-3855 ◽  
Author(s):  
Maxime Bélanger ◽  
Sylvain Moineau

ABSTRACTThe lactococcal abortive phage infection mechanism AbiQ recently was classified as a type III toxin-antitoxin system in which the toxic protein (ABIQ) is regulated following cleavage of its repeated noncoding RNA antitoxin (antiQ). In this study, we investigated the role of the antitoxin in antiphage activity. The cleavage ofantiQby ABIQ was characterized using 5′ rapid amplification of cDNA ends PCR and was located in an adenine-rich region ofantiQ. We next generated a series of derivatives with point mutations withinantiQor with various numbers ofantiQrepetitions. These modifications were analyzed for their effect on the antiphage activity (efficiency of plaquing) and on the endoribonuclease activity (Northern hybridization). We observed that increasing or reducing the number ofantiQrepeats significantly decreased the antiphage activity of the system. Several point mutations had a similar effect on the antiphage activity and were associated with changes in the digestion profile ofantiQ. Interestingly, a point mutation in the putative pseudoknot structure ofantiQmutants led to an increased AbiQ antiphage activity, thereby offering a novel way to increase the activity of an abortive infection mechanism.


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