scholarly journals High expression of COMMD7 is an adverse prognostic factor in acute myeloid leukemia

Aging ◽  
2021 ◽  
Author(s):  
Kongfei Li ◽  
Lieguang Chen ◽  
Hua Zhang ◽  
Lu Wang ◽  
Keya Sha ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Prognostic Factor ◽  
Myeloid Leukemia ◽  
High Expression ◽  
Adverse Prognostic Factor ◽  
Acute Myeloid

scholarly journals High HSPA8 expression predicts adverse outcomes of acute myeloid leukemia

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jun Li ◽  
Zheng Ge
Keyword(s):  
Overall Survival ◽  
Acute Myeloid Leukemia ◽  
Prognostic Factor ◽  
Myeloid Leukemia ◽  
Cell Function ◽  
Adverse Outcomes ◽  
High Expression ◽  
Micro Rnas ◽  
Acute Myeloid

Abstract Background Acute myeloid leukemia (AML) remains one of the most common hematological malignancies, posing a serious challenge to human health. HSPA8 is a chaperone protein that facilitates proper protein folding. It contributes to various activities of cell function and also is associated with various types of cancers. To date, the role of HSPA8 in AML is still undetermined. Methods In this study, public datasets available from the TCGA (Cancer Genome Atlas) and GEO (Gene Expression Omnibus) were mined to discover the association between the expression of HSPA8 and clinical phenotypes of CN-AML. A series of bioinformatics analysis methods, including functional annotation and miRNA-mRNA regulation network analysis, were employed to investigate the role of HSPA8 in CN-AML. Results HSPA8 was highly expressed in the AML patients compared to the healthy controls. The high HSPA8 expression had lower overall survival (OS) rate than those with low HSPA8 expression. High expression of HSPA8 was also an independent prognostic factor for overall survival (OS) of CN-AML patients by multivariate analysis. The differential expressed genes (DEGs) associated with HSPA8 high expression were identified, and they were enriched PI3k-Akt signaling, cAMP signaling, calcium signaling pathway. HSPA8 high expression was also positively associated with micro-RNAs (hsa-mir-1269a, hsa-mir-508-3p, hsa-mir-203a), the micro-RNAs targeted genes (VSTM4, RHOB, HOBX7) and key known oncogenes (KLF5, RAN, and IDH1), and negatively associated with tumor suppressors (KLF12, PRKG1, TRPS1, NOTCH1, RORA). Conclusions Our research revealed HSPA8 as a novel potential prognostic factor to predict the survival of CN-AML patients. Our data also revealed the possible carcinogenic mechanism and the complicated microRNA-mRNA network associated with the HSPA8 high expression in AML.

scholarly journals High expression of MiR-98 is a good prognostic factor in acute myeloid leukemia patients treated with chemotherapy alone

2019 ◽  
Vol 10 (1) ◽  
pp. 178-185 ◽  
Author(s):  
Ning Hu ◽  
Zhiheng Cheng ◽  
Yifan Pang ◽  
Hongmian Zhao ◽  
Li Chen ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Prognostic Factor ◽  
Myeloid Leukemia ◽  
High Expression ◽  
Acute Myeloid

scholarly journals Loss of TRIM62 Expression Is an Independent Adverse Prognostic Factor in Acute Myeloid Leukemia

2015 ◽  
Vol 15 (2) ◽  
pp. 115-127.e15 ◽  
Author(s):  
Alfonso Quintás-Cardama ◽  
Nianxiang Zhang ◽  
Yi Hua Qiu ◽  
Sean Post ◽  
Chad J. Creighton ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Prognostic Factor ◽  
Myeloid Leukemia ◽  
Adverse Prognostic Factor ◽  
Independent Adverse Prognostic Factor ◽  
Acute Myeloid

scholarly journals CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

Cell ◽  
2009 ◽  
Vol 138 (2) ◽  
pp. 286-299 ◽  
Author(s):  
Ravindra Majeti ◽  
Mark P. Chao ◽  
Ash A. Alizadeh ◽  
Wendy W. Pang ◽  
Siddhartha Jaiswal ◽  
...  
Keyword(s):  
Stem Cells ◽  
Acute Myeloid Leukemia ◽  
Prognostic Factor ◽  
Myeloid Leukemia ◽  
Therapeutic Antibody ◽  
Leukemia Stem Cells ◽  
Adverse Prognostic Factor ◽  
Human Acute Myeloid Leukemia ◽  
Acute Myeloid

Methylation of CTNNA1 promoter: Frequent but not an adverse prognostic factor in acute myeloid leukemia

2014 ◽  
Vol 38 (5) ◽  
pp. 613-618 ◽  
Author(s):  
Xing-xing Chen ◽  
Jiang Lin ◽  
Jun Qian ◽  
Wei Qian ◽  
Jing Yang ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Prognostic Factor ◽  
Myeloid Leukemia ◽  
Adverse Prognostic Factor ◽  
Acute Myeloid

scholarly journals CIP2A high expression is a poor prognostic factor in normal karyotype acute myeloid leukemia

Haematologica ◽  
2015 ◽  
Vol 100 (5) ◽  
pp. e183-e185 ◽  
Author(s):  
E. Barragan ◽  
M. C. Chillon ◽  
R. Castello-Cros ◽  
N. Marcotegui ◽  
M. I. Prieto ◽  
...  
Keyword(s):  
Acute Myeloid Leukemia ◽  
Prognostic Factor ◽  
Myeloid Leukemia ◽  
Normal Karyotype ◽  
High Expression ◽  
Poor Prognostic Factor ◽  
Acute Myeloid
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