scholarly journals Programmed cell death-ligand 1 expression predicts poor treatment response and prognostic value in esophageal squamous cell carcinoma patients without esophagectomy

Aging ◽  
2021 ◽  
Author(s):  
Fang Zhang ◽  
Xiuyuan Zhu ◽  
Qi Zhang ◽  
Ping Zhou ◽  
Liang Hao
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Treatment Response ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Poor Treatment ◽  
Poor Treatment Response

Programmed cell death 1 expression in esophageal squamous cell carcinoma and association with clinical characteristics

2015 ◽  
Vol 52 (7) ◽  
pp. 176 ◽  
Author(s):  
L Li ◽  
Z Feng ◽  
Li Xiang-lei ◽  
W Hai-tao ◽  
W Zuo-pei ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Clinical Characteristics ◽  
Programmed Cell Death 1

The concentration of programmed cell death-ligand 1 in the peripheral blood is a useful biomarker for esophageal squamous cell carcinoma

Esophagus ◽  
2018 ◽  
Vol 15 (2) ◽  
pp. 103-108 ◽  
Author(s):  
Yasunori Akutsu ◽  
Kentaro Murakami ◽  
Masayuki Kano ◽  
Takeshi Toyozumi ◽  
Yasunori Matsumoto ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Peripheral Blood

scholarly journals Programmed cell death ligand 1 expression in esophageal squamous cell carcinoma

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Lei Guo ◽  
Ying Ji ◽  
Wei Guo ◽  
Peng Song ◽  
Xue-Min Xue ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell

scholarly journals Indoleamine 2,3-dioxygenase 1 and Programmed Cell Death-ligand 1 Co-expression Predicts Poor Pathologic Response and Recurrence in Esophageal Squamous Cell Carcinoma after Neoadjuvant Chemoradiotherapy

Cancers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 169 ◽  
Author(s):  
Sha Zhou ◽  
Lei Zhao ◽  
Zhaohui Liang ◽  
Songran Liu ◽  
Yong Li ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Neoadjuvant Chemoradiotherapy ◽  
Pathologic Response ◽  
Indoleamine 2,3 Dioxygenase ◽  
Ido1 Expression

This study aimed to investigate the impact of indoleamine 2,3-dioxygenase 1 (IDO1) expression, programmed cell death-ligand 1 (PD-L1) expression, CD8+ tumor-infiltrating lymphocyte (TIL) status, and their combination on pathologic complete response (pCR) and recurrence in esophageal squamous cell carcinoma (ESCC) treated with neoadjuvant chemoradiotherapy (CRT). Indoleamine 2,3-dioxygenase 1, PD-L1, and CD8+ TIL statuses were evaluated by immunohistochemical analysis on pre-CRT biopsies of 158 patients. Sixty-eight patients (43.0%) achieved pCR after neoadjuvant CRT and 48 patients (30.4%) developed recurrences after surgery. IDO1 and PD-L1 proteins were co-expressed in 28 patients (17.7%). Indoleamine 2,3-dioxygenase 1 positive patients showed a significantly lower pCR rate than IDO1 negative patients (28.6% vs. 51.0%, P = 0.007). Similarly, PD-L1 high expression was significantly negatively correlated with pCR rate (27.3% vs. 51.5%, P = 0.004). On multivariate analysis, IDO1 expression was an independent prognostic factor for developing recurrences. Stratification analysis revealed that patients with co-expression of IDO1 and PD-L1 were significantly associated with a lower pCR rate and worse recurrence-free survival than those with one or none positive protein. In conclusion, IDO1 and PD-L1 co-expression could predict poor pathologic response and high risk of recurrence in ESCC after neoadjuvant CRT, indicating a subset of patients who may benefit from CRT combined with immunotherapy.

scholarly journals Prognostic Function of Programmed Cell Death-Ligand 1 in Esophageal Squamous Cell Carcinoma Patients Without Preoperative Therapy: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Hongxia Cui ◽  
Yarong Li ◽  
Su Li ◽  
Guangxuan Liu
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Esophageal Squamous Cell Carcinoma ◽  
Quality Assessment ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Meta Analysis ◽  
Preoperative Therapy ◽  
Lymph Node Status

BackgroundStudies investigating the correlation between the expression of programmed cell death-ligand 1 (PD-L1) and prognosis in patients with esophageal squamous cell carcinoma (ESCC) not receiving preoperative therapy have increased significantly, but conclusions remain inconclusive. Therefore, this study aimed to determine the association between clinical outcomes and expression of PD-L1 in ESCC patients without preoperative therapy.MethodsWe conducted a comprehensive literature search using four databases up to May 2020. Quality assessment was carried out according to the Newcastle–Ottawa Quality Assessment Scale (NOS). Hazard ratios (HRs) were used to analyze the association between PD-L1 expression with prognosis. Furthermore, we evaluated the correlation between PD-L1 and clinicopathological characteristics using odds ratios (ORs) and 95% confidence intervals (CIs).ResultsTwenty studies (19 publications) comprising 3,677 patients were included in this meta-analysis. We found that the expression of PD-L1 was not related to overall survival (OS, HR: 1.16, 95% CI: 0.94–1.42, p = 0.16) or disease-free survival (DFS, HR: 0.85, 95% CI: 0.66–1.10, p = 0.21) in ESCC. Furthermore, although PD-L1 expression was not significantly associated with sex, degree of differentiation, TNM stage, T stage, lymph node status, smoking, or alcohol use, the merged OR demonstrated that the expression of PD-L1 was higher in older patients compared to younger patients (OR: 1.40, 95% CI: 1.07–1.83, p = 0.01). No obvious publication bias was observed.ConclusionsOur present study illustrated that PD-L1 expression was not related to poor prognosis of ESCC patients not receiving preoperative therapy, albeit the association only showed a tendency for statistical significance. Notably, PD−L1 expression showed a significant association with age. This meta-analysis had several limitations; therefore, our results need to be verified through further large-scale and prospective studies.

Prognostic value of VEGF expression in primary esophageal squamous cell carcinoma

2004 ◽  
Vol 16 (2) ◽  
pp. 85-89 ◽  
Author(s):  
Wei-guo Xu ◽  
Guo-li Yang ◽  
Li-xin Zhou ◽  
Yu-quan Xie ◽  
Li-jian Zhang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Vegf Expression
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