scholarly journals Twists and turns in Kras-driven tumor initiation

Aging ◽  
2021 ◽  
Author(s):  
Yoshiaki Maru ◽  
Yoshitaka Hippo
Keyword(s):  
Tumor Initiation

YAP-induced tumor initiation mediates a switch in hepatic macrophage identity via the Ccl2/Ccr2 axis

2020 ◽  
Author(s):  
S Thomann ◽  
S Weiler ◽  
T Wei ◽  
C Sticht ◽  
C De La Torre ◽  
...  
Keyword(s):  
Tumor Initiation ◽  
Hepatic Macrophage

scholarly journals Inhibition of histone methyltransferase G9a attenuates liver cancer initiation by sensitizing DNA-damaged hepatocytes to p53-induced apoptosis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Takuma Nakatsuka ◽  
Keisuke Tateishi ◽  
Hiroyuki Kato ◽  
Hiroaki Fujiwara ◽  
Keisuke Yamamoto ◽  
...  
Keyword(s):  
Dna Damage ◽  
Epigenetic Modification ◽  
Histone Methyltransferase ◽  
Preventive Strategy ◽  
Tumor Initiation ◽  
Liver Transcriptome ◽  
Genetic Abnormalities ◽  
Responsive Element ◽  
Induced Apoptosis

AbstractWhile the significance of acquired genetic abnormalities in the initiation of hepatocellular carcinoma (HCC) has been established, the role of epigenetic modification remains unknown. Here we identified the pivotal role of histone methyltransferase G9a in the DNA damage-triggered initiation of HCC. Using liver-specific G9a-deficient (G9aΔHep) mice, we revealed that loss of G9a significantly attenuated liver tumor initiation caused by diethylnitrosamine (DEN). In addition, pharmacological inhibition of G9a attenuated the DEN-induced initiation of HCC. After treatment with DEN, while the induction of γH2AX and p53 were comparable in the G9aΔHep and wild-type livers, more apoptotic hepatocytes were detected in the G9aΔHep liver. Transcriptome analysis identified Bcl-G, a pro-apoptotic Bcl-2 family member, to be markedly upregulated in the G9aΔHep liver. In human cultured hepatoma cells, a G9a inhibitor, UNC0638, upregulated BCL-G expression and enhanced the apoptotic response after treatment with hydrogen peroxide or irradiation, suggesting an essential role of the G9a-Bcl-G axis in DNA damage response in hepatocytes. The proposed mechanism was that DNA damage stimuli recruited G9a to the p53-responsive element of the Bcl-G gene, resulting in the impaired enrichment of p53 to the region and the attenuation of Bcl-G expression. G9a deletion allowed the recruitment of p53 and upregulated Bcl-G expression. These results demonstrate that G9a allows DNA-damaged hepatocytes to escape p53-induced apoptosis by silencing Bcl-G, which may contribute to the tumor initiation. Therefore, G9a inhibition can be a novel preventive strategy for HCC.

Chromosomal translocations inactivating CDKN2A support a single path for malignant peripheral nerve sheath tumor initiation

2021 ◽  
Author(s):  
Miriam Magallón-Lorenz ◽  
Juana Fernández-Rodríguez ◽  
Ernest Terribas ◽  
Edgar Creus-Batchiller ◽  
Cleofe Romagosa ◽  
...  
Keyword(s):  
Peripheral Nerve ◽  
Chromosomal Translocations ◽  
Nerve Sheath Tumor ◽  
Tumor Initiation ◽  
Peripheral Nerve Sheath Tumor ◽  
Nerve Sheath ◽  
Single Path

The effect of various dietary fats on skin tumor initiation

1991 ◽  
Vol 16 (3-4) ◽  
pp. 189-196 ◽  
Author(s):  
Mary Locniskar ◽  
Martha A. Belury ◽  
Adam G. Cumberland ◽  
Kelly E. Patrick ◽  
Susan M. Fischer
Keyword(s):  
Dietary Fats ◽  
Skin Tumor ◽  
Tumor Initiation

scholarly journals B26 Relationship of Sox2 and Rb in Tumor Initiation and Maintenance in Small-Cell Lung Cancer

2020 ◽  
Vol 15 (2) ◽  
pp. S35
Author(s):  
E. Voigt ◽  
H. Wollenzien ◽  
E. Thompson ◽  
J. Feiner ◽  
M. Vande Kamp ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Tumor Initiation ◽  
Small Cell Lung ◽  
Relationship Of

scholarly journals Molecular genetics of bladder cancer: Emerging mechanisms of tumor initiation and progression

2010 ◽  
Vol 28 (4) ◽  
pp. 429-440 ◽  
Author(s):  
David J. McConkey ◽  
Sangkyou Lee ◽  
Woonyoung Choi ◽  
Mai Tran ◽  
Tadeusz Majewski ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Molecular Genetics ◽  
Tumor Initiation

scholarly journals Exercise Reduces Tumor Initiation and Progression in Mouse Models

2016 ◽  
Vol 6 (4) ◽  
pp. 339.1-339
Keyword(s):  
Mouse Models ◽  
Tumor Initiation

scholarly journals Genes Involved in Viral Carcinogenesis and Tumor Initiation in Hepatitis C Virus-Induced Hepatocellular Carcinoma

2009 ◽  
Vol 15 (3-4) ◽  
pp. 85-94 ◽  
Author(s):  
Valeria R. Mas ◽  
Daniel G. Maluf ◽  
Kellie J. Archer ◽  
Kenneth Yanek ◽  
Xiangrong Kong ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Tumor Initiation ◽  
Viral Carcinogenesis

scholarly journals Research progress on the regulation of tumor initiation and development by the forkhead box Q1 gene

2018 ◽  
Vol 14 (1) ◽  
pp. 6 ◽  
Author(s):  
Qiang Guo ◽  
Hui Tang ◽  
Jinjin Zhang
Keyword(s):  
Research Progress ◽  
Tumor Initiation ◽  
Forkhead Box

scholarly journals The mitochondrial genetic landscape in neuroblastoma from tumor initiation to relapse

Oncotarget ◽  
2015 ◽  
Vol 7 (6) ◽  
pp. 6620-6625 ◽  
Author(s):  
Lara M. Riehl ◽  
Johannes H. Schulte ◽  
Medhanie A. Mulaw ◽  
Meike Dahlhaus ◽  
Matthias Fischer ◽  
...  
Keyword(s):  
Tumor Initiation ◽  
Genetic Landscape
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