scholarly journals Identification of a competing endogenous RNA network related to immune signature in clear cell renal cell carcinoma

Aging ◽  
2021 ◽  
Author(s):  
Yuke Zhang ◽  
Jiangwen Dai ◽  
Weifeng Huang ◽  
Qingsong Chen ◽  
Wei Chen ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Competing Endogenous Rna ◽  
Cell Renal Cell Carcinoma ◽  
Immune Signature ◽  
Competing Endogenous Rna Network

scholarly journals A prognostic nomogram based on competing endogenous RNA network for clear‐cell renal cell carcinoma

2021 ◽  
Author(s):  
Yun Peng ◽  
Shangrong Wu ◽  
Zihan Xu ◽  
Dingkun Hou ◽  
Nan Li ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Competing Endogenous Rna ◽  
Cell Renal Cell Carcinoma ◽  
Competing Endogenous Rna Network

A prognostic nomogram based on competing endogenous RNA network for clear-cell renal cell carcinoma

2020 ◽  
Author(s):  
Yun Peng ◽  
Shangrong Wu ◽  
Zihan Xu ◽  
Dingkun Hou ◽  
Nan Li ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Rna Sequencing ◽  
Renal Cell ◽  
Cox Regression ◽  
Clear Cell ◽  
Gene Signature ◽  
Expression Data ◽  
Competing Endogenous Rna ◽  
Cell Renal Cell Carcinoma

Abstract Backgroud Clear-cell renal cell carcinoma (ccRCC) is stubborn to traditional chemotherapy and radiation treatment, which makes its clinical management a major challenge. Recently, we have made efforts to understand the etiology of ccRCC. Increasing evidence revealed that the competing endogenous RNA (ceRNA) were involved in the development of various tumor. However, it’s scant for studying on ccRCC, and a comprehensive analysis of prognostic model based on lncRNA-miRNA-mRNA ceRNA regulatory network of ccRCC with large-scale sample size and RNA‐sequencing expression data is still limited. Methods RNA‐sequencing expression data were taken out from GTEx database and TCGA database, A total of 354 samples with ccRCC and 157 normal controlled samples were included in our study. The ccRCC-specific genes were obtained from WGCNA and differential expression analysis. Following, the communication between mRNAs and lncRNAs and target miRNAs were predicted by MiRcode, starBase, miRTarBase, and TargetScan. A gene signature of eight genes was constructed by univariate Cox regression, lasso methods and multivariate Cox regression analysis. Results A total of 2191 mRNAs and 1377 lncRNAs was identified, and a dys-regulated ceRNA network for ccRCC was established using 7 mRNAs, 363 lncRNAs, and 3 miRNAs. Further, a gene signature in cluding 8 genes based on this ceRNA was constructed, meanwhile, a nomogram predicting 1-, 3-, 5-year survival probability containing both clinical characteristics and ccRCC-specific gene signatures was developed. Conclusion It could contribute to a better understanding of ccRCC tumorigenesis mechanism and guide clinicians to make a more accurate treatment decision.

scholarly journals Identification of a lncRNA‑associated competing endogenous RNA‑regulated network in clear cell renal cell carcinoma

2019 ◽  
Author(s):  
Beibei Liu ◽  
Tantu Ma ◽  
Qingwen Li ◽  
Sheng Wang ◽  
Wei Sun ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Competing Endogenous Rna ◽  
Cell Renal Cell Carcinoma

scholarly journals Long Non-Coding RNA TTN-AS1 Serves as a Competing Endogenous RNA of miR-195 to Facilitate Clear Cell Renal Cell Carcinoma Progression

2020 ◽  
Vol Volume 12 ◽  
pp. 3091-3097
Author(s):  
Keng Lin ◽  
Hao Chen ◽  
Chunyan Su ◽  
Huanjin Zhu ◽  
Changchun Lai ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Competing Endogenous Rna ◽  
Cell Renal Cell Carcinoma ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals lncRNA PVT1 and its splicing variant function as competing endogenous RNA to regulate clear cell renal cell carcinoma progression

Oncotarget ◽  
2017 ◽  
Vol 8 (49) ◽  
pp. 85353-85367 ◽  
Author(s):  
Tao Yang ◽  
Hui Zhou ◽  
Peijun Liu ◽  
Libin Yan ◽  
Weimin Yao ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Competing Endogenous Rna ◽  
Cell Renal Cell Carcinoma ◽  
Splicing Variant

scholarly journals Identification of autophagy-related long non-coding RNA prognostic and immune signature for clear cell renal cell carcinoma

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Yankang Cui ◽  
Shaobo Zhang ◽  
Chenkui Miao ◽  
Chao Liang ◽  
Xiaochao Chen ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Immune Signature ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Pseudogene PTENP1 Functions as a Competing Endogenous RNA to Suppress Clear-Cell Renal Cell Carcinoma Progression

2014 ◽  
Vol 13 (12) ◽  
pp. 3086-3097 ◽  
Author(s):  
Gan Yu ◽  
Weimin Yao ◽  
Kiranmai Gumireddy ◽  
Anping Li ◽  
Ji Wang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Competing Endogenous Rna ◽  
Cell Renal Cell Carcinoma

638: Macroscopic Tumor Necrosis is a Prognostic Indicator for Non-Metastatic Clear Cell Renal Cell Carcinoma

2007 ◽  
Vol 177 (4S) ◽  
pp. 214-214
Author(s):  
Sung Kyu Hong ◽  
Byung Kyu Han ◽  
In Ho Chang ◽  
June Hyun Han ◽  
Ji Hyung Yu ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumor Necrosis ◽  
Clear Cell ◽  
Prognostic Indicator ◽  
Cell Renal Cell Carcinoma ◽  
Macroscopic Tumor
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