scholarly journals Prognostic value of the neutrophil-to-lymphocyte ratio in the ARQ 197-215 second-line study for advanced hepatocellular carcinoma

Oncotarget ◽  
2017 ◽  
Vol 8 (9) ◽  
pp. 14408-14415 ◽  
Author(s):  
Nicola Personeni ◽  
Laura Giordano ◽  
Giovanni Abbadessa ◽  
Camillo Porta ◽  
Ivan Borbath ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Value ◽  
Neutrophil To Lymphocyte Ratio ◽  
Advanced Hepatocellular Carcinoma ◽  
Second Line ◽  
Lymphocyte Ratio ◽  
Arq 197

Pre-treatment neutrophil-to-lymphocyte ratio affects survival in patients with advanced hepatocellular carcinoma treated with sorafenib

2014 ◽  
Vol 31 (11) ◽  
Author(s):  
Leonardo Gomes da Fonseca ◽  
Romulado Barroso-Sousa ◽  
Afonso da Silva Alves Bento ◽  
Bruna Paccola Blanco ◽  
Gabriel Luis Valente ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Neutrophil To Lymphocyte Ratio ◽  
Advanced Hepatocellular Carcinoma ◽  
Lymphocyte Ratio ◽  
Pre Treatment

Baseline neutrophil-to-lymphocyte ratio (NLR) and early toxicity as prognostic factors in advanced hepatocellular carcinoma patients treated with sorafenib.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e15159-e15159
Author(s):  
Gema Bruixola ◽  
Oscar Mauricio Niño ◽  
Robert Diaz-Beveridge ◽  
Encarnacion Reche ◽  
Carmen Salvador ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Factors ◽  
Neutrophil To Lymphocyte Ratio ◽  
Advanced Hepatocellular Carcinoma ◽  
Lymphocyte Ratio ◽  
Early Toxicity

Myeloid-deprived suppressor cell mediated the prognostic value of platelet-to-lymphocyte ratio for advanced hepatocellular carcinoma patients.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 331-331
Author(s):  
Xing Li ◽  
Xiang-yuan Wu ◽  
Nan Jiang ◽  
Yan-Fang Xing ◽  
Dong-hao Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Targeted Therapy ◽  
Prognostic Value ◽  
Mononuclear Cells ◽  
Suppressor Cell ◽  
Advanced Hepatocellular Carcinoma ◽  
Platelet To Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Counts ◽  
Healthy Donors

331 Background: Myeloid Deprived Suppressor Cell (MDSC) has been recoganized as a promising target for hepatocellular carcinoma (HCC). However, targeted therapy on MDSC failed to display convincing efficacy. Optimization of patient selection to find the most potential beneficiaries might be a solution to this issue. In the present study, we aimed to identify clinical parameters relevant to MDSC level in HCC patients for future MDSC targeted therapy. Methods: In the present study, a series of 55 HCC patients (prospective group) and 20 healthy donors were analyzed investigating frequencies of MDSC in peripheral blood mononuclear cells (PBMC). Results: As a result, we found that MDSC level was increased in HCC patients compared to healthy donors (10.33% vs 1.54%, p< 0.0001). The monocytes (r2= 0.2875, p< 0.0001), neutrophils (r2= 0.3630, p< 0.0001) and platelet counts (r2= 0.0828, p= 0.0331) in circulation was positively associated with MDSC level. Then, the prognostic value of the above predictors was determined in a retrospective database of 243 HCC patients (retrospective group). The baseline characteristics of prospective and retrospective group were similar. Platelet-to-lymphocyte ratio (PLR) were confirmed to be an independent predictor for OS ( p= 0.003) with the rest parameters presented negative results. Then, advanced HCC patients were divided into two groups based on PLR value ≤111.23 or > 111.23 according to ROC analysis. Patients with low PLR presented higher 3-month survival rate (57.6% vs 37.6%) compared with patients with high PLR. PLR was associated with aggressive behavior of malignancies, such as distant metastasis and portal vein thrombosis. Conclusions: In summary, the present study firstly indentified blood platelet counts was a predictor of MDSC level in PBMC for HCC patients. And, patients with higher PLR might be the optimal patient subgroup for MDSC targeted therapy.

scholarly journals Prognostic value of C-reactive protein and neutrophil-to-lymphocyte ratio in patients with hepatocellular carcinoma

BMC Cancer ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Byong Sun Oh ◽  
Jeong Won Jang ◽  
Jung Hyun Kwon ◽  
Chan Ran You ◽  
Kyu Won Chung ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Value ◽  
Neutrophil To Lymphocyte Ratio ◽  
C Reactive Protein ◽  
Lymphocyte Ratio ◽  
Reactive Protein

scholarly journals Erratum to: Neutrophil-to-lymphocyte ratio acts as a prognostic factor for patients with advanced hepatocellular carcinoma

Tumor Biology ◽  
2016 ◽  
Vol 37 (9) ◽  
pp. 12903-12903
Author(s):  
Xing Li ◽  
Zhan-Hong Chen ◽  
Xiao-Kun Ma ◽  
Jie Chen ◽  
Dong-Hao Wu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Prognostic Factor ◽  
Neutrophil To Lymphocyte Ratio ◽  
Advanced Hepatocellular Carcinoma ◽  
Lymphocyte Ratio
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