scholarly journals Prognostic role of long noncoding RNA ZFAS1 in cancer patients: a systematic review and meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (59) ◽  
pp. 100490-100498 ◽  
Author(s):  
Tian Lan ◽  
Xiong Lan ◽  
Guangcai Li ◽  
Zhen Zheng ◽  
Minghua Zhang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Patients ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Meta Analysis ◽  
Prognostic Role

scholarly journals The prognostic role of long noncoding RNA CRNDE in cancer patients: a systematic review and meta-analysis

Neoplasma ◽  
2019 ◽  
Vol 66 (01) ◽  
pp. 73-82 ◽  
Author(s):  
W. Wang ◽  
F. Yuan ◽  
J. Xu
Keyword(s):  
Systematic Review ◽  
Cancer Patients ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Meta Analysis ◽  
Prognostic Role

scholarly journals Circulating MicroRNAs as Prognostic Molecular Biomarkers in Human Head and Neck Cancer: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Shree Ram Lamichhane ◽  
Thanuja Thachil ◽  
Harriet Gee ◽  
Natalie Milic
Keyword(s):  
Systematic Review ◽  
Overall Survival ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Meta Analysis ◽  
Prognostic Role ◽  
Circulating Micrornas

Background. Circulating microRNAs (miRNAs) are potential molecular biomarkers for cancer detection; however, little is known about their prognostic role in head and neck cancer. This current study is aimed at evaluating the role of novel miRNAs in the survival of head and neck cancer patients. Materials and Methods. We performed a systematic literature search using online databases for articles published between December 2006 and February 2019. A meta-analysis was conducted to assess the correlation between miRNA expressions and overall survival (OS) among the selected head and neck cancer studies. After multilevel screening by reviewers, meta-analysis was performed using hazard ratios (HR) and associated 95% confidence interval (CI) of survival to calculate a pooled effect size. Result. A total of 1577 patients across 13 studies were included in the literature review, with 18 miRNAs upregulated and 4 miRNAs downregulated predicting a poor overall survival. The forest plot generated using cumulated survival data resulted in a pooled HR value of 2.943 (95% CI: 2.394-3.618) indicating a strong association of dysregulated miRNA expression with a poor outcome. Only 2 miRNAs—low levels of miR-9 and high levels of miR-483-5p—were observed in two studies, both showing a significant association with overall cancer survival. Conclusion. To our knowledge, this is the first comprehensive systematic review and meta-analysis that examines the prognostic role of circulating miRNAs from blood in head and neck cancer patients. The combined effect estimates a HR across multiple studies and also supports the previous individual findings that an alteration in miRNA expression is highly associated with poor prognosis. This has the potential to use serum and/or plasma miRNAs as biomarkers and become novel tools for predicting the prognosis of head and neck cancer patients in the near future.

scholarly journals Prognostic Role of Long Noncoding RNA BANCR in Solid Tumors: A Meta-Analysis

2017 ◽  
Vol 16 (6) ◽  
pp. 727-735
Author(s):  
Jun Zhao ◽  
Yali Qi ◽  
Jiahao Hu ◽  
Wenwen Dai ◽  
Yifei Chen
Keyword(s):  
Solid Tumors ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Meta Analysis ◽  
Prognostic Role

scholarly journals Prognostic Value of Long Noncoding RNA SPRY4-IT1 on Survival Outcomes in Human Carcinomas: A Systematic Review and Meta-Analysis with TCGA Database

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Hai-mei Wang ◽  
Hui-jie Li ◽  
Jun-zhen Chen ◽  
Ke Pei ◽  
Qian Zhang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cancer Patients ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Meta Analysis ◽  
Cancer Prognosis ◽  
Survival Outcomes ◽  
Human Cancers ◽  
Human Carcinomas ◽  
Tcga Dataset

Background. Emerging evidences have shown that long noncoding RNA SPRY4-IT1 can be aberrantly expressed in human cancers, and it could be an unfavorable prognostic factor in cancer patients. However, the prognostic mechanism of SPRY4-IT1 is still unclear. This study is aimed at evaluating its potential predictive value for cancer prognosis. Methods. We thoroughly searched PubMed, Embase, Web of Science, and MEDLINE databases so as to explore the relationship between SPRY4-IT1 expression and cancer prognosis value. Then, TCGA datasets were used to validate the results of our meta-analysis. Results. In all, seventeen studies involving 1650 patients were included in this meta-analysis. Pooled results showed that high expression of SPRY4-IT1 was significantly correlated with poor OS ( HR = 1.96 , 95% confidence interval CI = 1.47 ‐ 2.62 , P < 0.001 ) in cancer patients. Furthermore, exploration of TCGA dataset further validated that SPRY4-IT1 was aberrantly expressed in various cancers, which partially confirmed our results in this meta-analysis. Conclusions. The present systematic review and meta-analysis implicated that the aberrant expressions of lncRNA SPRY4-IT1 were strongly associated with clinical survival outcomes in various cancers and therefore might serve as a promising biomarker for predicting prognosis of human cancers.

scholarly journals Prognostic role of long noncoding RNA NEAT1 in various carcinomas: a meta-analysis

2017 ◽  
Vol Volume 10 ◽  
pp. 993-1000 ◽  
Author(s):  
Tao Chen ◽  
Hui Wang ◽  
Peng Yang ◽  
Zhen-Yu He
Keyword(s):  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Meta Analysis ◽  
Prognostic Role

scholarly journals Letter to the editor regarding the article “Prognostic role of long noncoding RNA NEAT1 in various carcinomas: a meta-analysis”

2017 ◽  
Vol Volume 10 ◽  
pp. 2823-2824
Author(s):  
He Yu ◽  
Peng Wang ◽  
Xiong Zhang
Keyword(s):  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Meta Analysis ◽  
Prognostic Role ◽  
Letter To The Editor

scholarly journals The prognostic role of KRAS and BRAF in patients undergoing surgical resection of colorectal cancer liver metastasis: a systematic review and meta-analysis

2016 ◽  
Vol 27 ◽  
pp. iv41
Author(s):  
F. Passiglia ◽  
A. Galvano ◽  
S. Rizzo ◽  
A. Listì ◽  
N. Barraco ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Systematic Review ◽  
Liver Metastasis ◽  
Surgical Resection ◽  
Meta Analysis ◽  
Prognostic Role ◽  
Colorectal Cancer Liver Metastasis
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