scholarly journals SHARPIN stabilizes estrogen receptor α and promotes breast cancer cell proliferation

Oncotarget ◽  
2017 ◽  
Vol 8 (44) ◽  
pp. 77137-77151 ◽  
Author(s):  
Ting Zhuang ◽  
Sifan Yu ◽  
Lichen Zhang ◽  
Huijie Yang ◽  
Xin Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Estrogen Receptor ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Estrogen Receptor Α ◽  
Cancer Cell Proliferation ◽  
Breast Cancer Cell Proliferation

scholarly journals OTUD7B stabilizes estrogen receptor α and promotes breast cancer cell proliferation

2021 ◽  
Vol 12 (6) ◽  
Author(s):  
Jianing Tang ◽  
Zeyu Wu ◽  
Zelin Tian ◽  
Wei Chen ◽  
Gaosong Wu
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Estrogen Receptor ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Estrogen Receptor Α ◽  
Dependent Manner ◽  
Cancer Cell Proliferation ◽  
Breast Cancer Cell Proliferation ◽  
Positive Breast Cancer

AbstractBreast cancer is the most common malignancy in women worldwide. Estrogen receptor α (ERα) is expressed in ∼70% of breast cancer cases and promotes estrogen-dependent cancer progression. In the present study, we identified OTU domain-containing 7B (OTUD7B), a deubiquitylase belonging to A20 subgroup of ovarian tumor protein superfamily, as a bona fide deubiquitylase of ERα in breast cancer. OTUD7B expression was found to be positively correlated with ERα in breast cancer and associated with poor prognosis. OTUD7B could interact with, deubiquitylate, and stabilize ERα in a deubiquitylation activity-dependent manner. Depletion of OTUD7B decreased ERα protein level, the expression of ERα target genes, and the activity of estrogen response element in breast cancer cells. In addition, OTUD7B depletion significantly decreased ERα-positive breast cancer cell proliferation and migration. Finally, overexpression of ERα could rescue the suppressive effect induced by OTUD7B depletion, suggesting that the ERα status was essential to the function of OTUD7B in breast carcinogenesis. In conclusion, our study revealed an interesting post-translational mechanism between ERα and OTUD7B in ERα-positive breast cancer. Targeting the OTUD7B–ERα complex may prove to be a potential approach to treat patients with ERα-positive breast cancer.

scholarly journals TRIM11 promotes breast cancer cell proliferation by stabilizing estrogen receptor α

Neoplasia ◽  
2020 ◽  
Vol 22 (9) ◽  
pp. 343-351 ◽  
Author(s):  
Jianing Tang ◽  
Yongwen Luo ◽  
Zelin Tian ◽  
Xing Liao ◽  
Qiuxia Cui ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Estrogen Receptor ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Estrogen Receptor Α ◽  
Cancer Cell Proliferation ◽  
Breast Cancer Cell Proliferation

scholarly journals S6 Kinase 1 Regulates Estrogen Receptor α in Control of Breast Cancer Cell Proliferation

2008 ◽  
Vol 284 (10) ◽  
pp. 6361-6369 ◽  
Author(s):  
Rachel L. Yamnik ◽  
Alla Digilova ◽  
Daphne C. Davis ◽  
Z. Nilly Brodt ◽  
Christopher J. Murphy ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Estrogen Receptor ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Estrogen Receptor Α ◽  
Cancer Cell Proliferation ◽  
Breast Cancer Cell Proliferation ◽  
S6 Kinase
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