scholarly journals Melatonin up-regulates the expression of the GATA-4 transcription factor and increases testosterone secretion from Leydig cells through RORα signaling in an in vitro goat spermatogonial stem cell differentiation culture system

Oncotarget ◽  
2017 ◽  
Vol 8 (66) ◽  
pp. 110592-110605 ◽  
Author(s):  
Shou-Long Deng ◽  
Yan Zhang ◽  
Kun Yu ◽  
Xiu-Xia Wang ◽  
Su-Ren Chen ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Culture System ◽  
Leydig Cells ◽  
Stem Cell Differentiation ◽  
Spermatogonial Stem Cell ◽  
Testosterone Secretion

scholarly journals Transient suppression of transplanted spermatogonial stem cell differentiation restores fertility in mice

2021 ◽  
Author(s):  
Yoshiaki Nakamura ◽  
David J. Jörg ◽  
Yayoi Kon ◽  
Benjamin D. Simons ◽  
Shosei Yoshida
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Spermatogonial Stem Cell

scholarly journals Chromobox Protein Homolog 3 Is Essential for Stem Cell Differentiation to Smooth Muscles In Vitro and in Embryonic Arteriogenesis

2011 ◽  
Vol 31 (8) ◽  
pp. 1842-1852 ◽  
Author(s):  
Qingzhong Xiao ◽  
Gang Wang ◽  
Xiaoke Yin ◽  
Zhenling Luo ◽  
Andriani Margariti ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Smooth Muscles ◽  
Stem Cell Differentiation

scholarly journals Human adipose stem cell differentiation is highly affected by cancer cells both in vitro and in vivo: implication for autologous fat grafting

2017 ◽  
Vol 8 (1) ◽  
pp. e2568-e2568 ◽  
Author(s):  
Francesca Paino ◽  
Marcella La Noce ◽  
Diego Di Nucci ◽  
Giovanni Francesco Nicoletti ◽  
Rosa Salzillo ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Stem Cell Differentiation ◽  
Fat Grafting ◽  
Adipose Stem Cell ◽  
Autologous Fat Grafting ◽  
Autologous Fat ◽  
Human Adipose Stem Cell

scholarly journals Developmental Pathways Pervade Stem Cell Responses to Evolving Extracellular Matrices of 3D Bioprinted Microenvironments

2018 ◽  
Vol 2018 ◽  
pp. 1-15
Author(s):  
Quyen A. Tran ◽  
Visar Ajeti ◽  
Brian T. Freeman ◽  
Paul J. Campagnola ◽  
Brenda M. Ogle
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Human Mesenchymal Stem Cells ◽  
Early Time ◽  
Stem Cell Differentiation ◽  
Model Systems ◽  
Ecm Remodeling ◽  
Time Points ◽  
3D Microenvironment

Developmental studies and 3D in vitro model systems show that the production and engagement of extracellular matrix (ECM) often precede stem cell differentiation. Yet, unclear is how the ECM triggers signaling events in sequence to accommodate multistep process characteristic of differentiation. Here, we employ transcriptome profiling and advanced imaging to delineate the specificity of ECM engagement to particular differentiation pathways and to determine whether specificity in this context is a function of long-term ECM remodeling. To this end, human mesenchymal stem cells (hMSCs) were cultured in 3D bioprinted prisms created from ECM proteins and associated controls. We found that exogenous ECM provided in 3D microenvironments at early time points impacts on the composition of microenvironments at later time points and that each evolving 3D microenvironment is uniquely poised to promote stem cell differentiation. Moreover, 2D cultures undergo minimal ECM remodeling and are ill-equipped to stimulate pathways associated with development.

scholarly journals A bioengineering approach to Schlemm's canal-like stem cell differentiation for in vitro glaucoma drug screening

2020 ◽  
Vol 105 ◽  
pp. 203-213 ◽  
Author(s):  
Yangzi Isabel Tian ◽  
Xulang Zhang ◽  
Karen Torrejon ◽  
John Danias ◽  
Sofya Gindina ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Drug Screening ◽  
Stem Cell Differentiation ◽  
Schlemm’S Canal ◽  
Schlemm's Canal
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