scholarly journals Association between polymorphism rs12722 in COL5A1 and musculoskeletal soft tissue injuries: a systematic review and meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 9 (20) ◽  
pp. 15365-15374 ◽  
Author(s):  
Zheng-Tao Lv ◽  
Shu-Tao Gao ◽  
Peng Cheng ◽  
Shuang Liang ◽  
Si-Yi Yu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Soft Tissue ◽  
Meta Analysis ◽  
Soft Tissue Injuries ◽  
Tissue Injuries

scholarly journals The Effectiveness of Physical Agents for Lower-Limb Soft Tissue Injuries: A Systematic Review

2016 ◽  
Vol 46 (7) ◽  
pp. 523-554 ◽  
Author(s):  
Hainan Yu ◽  
Kristi Randhawa ◽  
Pierre Côté ◽  
Optima Collaboration
Keyword(s):  
Systematic Review ◽  
Soft Tissue ◽  
Lower Limb ◽  
Soft Tissue Injuries ◽  
Tissue Injuries

scholarly journals Efficacy of prolotherapy in comparison to other therapies for chronic soft tissue injuries: A systematic review and network meta-analysis

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0252204
Author(s):  
Siew-Li Goh ◽  
Zulkarnain Jaafar ◽  
Yan-Nee Gan ◽  
Alston Choong ◽  
Jaspreet Kaur ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Corticosteroid Injection ◽  
Meta Analysis ◽  
Random Effect ◽  
Soft Tissue Injuries ◽  
Injection Therapy ◽  
Sensitivity Analyses ◽  
Functional Improvement ◽  
Time Points ◽  
Tissue Injuries

Introduction Prolotherapy and other injections, primarily acting on pathways associated with maladaptive tissue repair, are recommended for recalcitrant chronic soft tissue injuries (CSTI). However, selection of injection is challenging due to mixed results. This network meta-analysis (NMA) aimed to compare prolotherapy with other therapies, particularly injections, for CSTI and establish robustness of the results. Methodology Pubmed, Medline, SPORTDiscus and Google scholar were searched from inception to 4th January 2021 for randomised controlled trials (RCTs) involving injection therapies (e.g. blood derivatives, corticosteroid, hyaluronic acid, botulinum toxin) for CSTI. The primary and secondary outcomes were pain and function, respectively, at (or nearest to) 6 months. Effect size (ES) was presented as standardised mean difference with 95% confidence interval (CI). Frequentist random effect NMA was used to generate the overall estimates, subgroup estimates (by region and measurement time point) and sensitivity analyses. Results A total of 91 articles (87 RCTs; 5859 participants) involving upper limb (74%), lower limb (23%) and truncal/hip (3%) injuries were included. At all time points, prolotherapy had no statistically significant pain benefits over other therapies. This observation remained unchanged when tested under various assumptions and with exclusion of studies with high risk of bias. Although prolotherapy did not offer statistically significant functional improvement compared to most therapies, its ES was consistently better than non-injections and corticosteroid injection for both outcomes. At selected time points and for selected injuries, prolotherapy demonstrated potentially better pain improvement over placebo (<4 months: shoulder [ES 0.65; 95% CI 0.00 to 1.30]; 4–8 months: elbow [ES 0.91; 95% CI 0.12 to 1.70]; >8 months: shoulder [ES 2.08; 95% CI 1.49, to 2.68]). Injections generally produced greater ES when combined with non-injection therapy. Conclusion While clinical outcomes were generally comparable across types of injection therapy, prolotherapy may be used preferentially for selected conditions at selected times.

scholarly journals Chondral and Soft Tissue Injuries Associated to Acute Patellar Dislocation: A Systematic Review

Life ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1360
Author(s):  
Filippo Migliorini ◽  
Emanuela Marsilio ◽  
Francesco Cuozzo ◽  
Francesco Oliva ◽  
Jörg Eschweiler ◽  
...  
Keyword(s):  
Systematic Review ◽  
Soft Tissue ◽  
Patellar Dislocation ◽  
Insertion Site ◽  
Patellofemoral Instability ◽  
Soft Tissue Injuries ◽  
Femoral Trochlea ◽  
Chondral Damage ◽  
Tissue Injuries ◽  
First Time

Introduction: Chondral and soft tissue injuries can be associated with first time patellar dislocation, but it is unclear how common they are, and which tissues are affected. A systematic review of the literature was performed to investigate the frequency, location, and extent of chondral and medial patellofemoral ligament (MPFL) injuries in patients following first time patellar dislocation. Methods: This systematic review was conducted according to the PRISMA guidelines. PubMed, Google Scholar, Embase, and Web of Science databases were accessed in November 2021. All the published clinical studies reporting the frequency, location, and extent of soft tissue lesions following first time patellar dislocation were accessed. Studies reporting data on habitual, congenital, or recurrent patellofemoral instability were excluded. Results: Data from 42 articles (2254 patients, mean age 21.6 ± 7.3 years) were retrieved. Ninety-eight percent of patients who experienced first time patellar dislocation demonstrated MPFL rupture at MRI. Forty-eight percent of MPFL ruptures were located at the patellar side, 34% at the femoral insertion site, and 18% in the midportion. Eighty-five percent of patients showed signs of patellar chondral damage at MRI, and trochlear chondral injuries were evidenced in 47% of patients. Intra-articular loose bodies were observed in 11.5% of patients. At arthroscopy, the medial facet and the crest of the patella more commonly exhibited chondral lesions than the lateral facet and femoral trochlea. Conclusions: Most patients suffer chondral damage and MPFL tears following after a first time patellar dislocation.

scholarly journals Effectiveness of electrical stimulation on rehabilitation after ligament and meniscal injuries: a systematic review

2011 ◽  
Vol 129 (6) ◽  
pp. 414-423 ◽  
Author(s):  
Aline Mizusaki Imoto ◽  
Stella Peccin ◽  
Gustavo Jerônimo Melo Almeida ◽  
Humberto Saconato ◽  
Álvaro Nagib Atallah
Keyword(s):  
Systematic Review ◽  
Anterior Cruciate Ligament ◽  
Electrical Stimulation ◽  
Soft Tissue ◽  
Muscle Strength ◽  
Cruciate Ligament ◽  
Soft Tissue Injuries ◽  
Controlled Trials ◽  
Tissue Injuries ◽  
Anterior Cruciate

CONTEXT AND OBJECTIVE: Electrical stimulation (ES) is widely used to strengthen muscles following ligament and meniscal injuries. The aim of this study was to evaluate the effectiveness of ES for rehabilitation after soft tissue injuries of the knee treated surgically or conservatively. DESIGN AND SETTING: Systematic review at the Brazilian Cochrane Center. METHODS: We searched the Cochrane Central Register of Controlled Trials (2010, Issue 12), Medline (Medical Analysis and Retrieval System Online) via PubMed (1966 to December 2010), Embase (Excerpta Medica database, 1980 to December 2010), Lilacs (Literatura Latino-Americana e do Caribe em Ciências da Saúde, 1982 to December 2010), and PEDro (Physiotherapy Evidence Database, 1929 to December 2010). The studies included were randomized controlled trials using ES to increase muscle strength for rehabilitation of patients with soft tissue injuries of the knee. Two authors independently evaluated studies for inclusion and performed data extraction and methodological quality assessment. RESULTS: Seventeen studies evaluating ES after anterior cruciate ligament reconstruction and two studies evaluating ES after meniscectomy were included. There was a statistically significant improvement in quadriceps strength through ES (mean difference, MD: -32.7; 95% confidence interval, CI: -39.92 to -25.48; n = 56) and in functional outcomes (MD -7; -12.78 to -1.22; n = 43) six to eight weeks after surgical reconstruction of the anterior cruciate ligament. CONCLUSION: There is evidence that ES coupled with conventional rehabilitation exercises may be effective in improving muscle strength and function two months after surgery

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