scholarly journals Correction: Lipolysis-stimulated lipoprotein receptor overexpression is a novel predictor of poor clinical prognosis and a potential therapeutic target in gastric cancer

Oncotarget ◽  
2021 ◽  
Vol 12 (21) ◽  
pp. 2232-2233
Author(s):  
Takahito Sugase ◽  
Tsuyoshi Takahashi ◽  
Satoshi Serada ◽  
Minoru Fujimoto ◽  
Tomoharu Ohkawara ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Therapeutic Target ◽  
Lipoprotein Receptor ◽  
Potential Therapeutic Target ◽  
Clinical Prognosis ◽  
Poor Clinical Prognosis

scholarly journals Lipolysis-stimulated lipoprotein receptor overexpression is a novel predictor of poor clinical prognosis and a potential therapeutic target in gastric cancer

Oncotarget ◽  
2018 ◽  
Vol 9 (68) ◽  
pp. 32917-32928 ◽  
Author(s):  
Takahito Sugase ◽  
Tsuyoshi Takahashi ◽  
Satoshi Serada ◽  
Minoru Fujimoto ◽  
Tomoharu Ohkawara ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Therapeutic Target ◽  
Lipoprotein Receptor ◽  
Potential Therapeutic Target ◽  
Clinical Prognosis ◽  
Poor Clinical Prognosis

scholarly journals SAA1 is upregulated in gastric cancer-associated fibroblasts possibly by its enhancer activation

2020 ◽  
Author(s):  
Yoshimi Yasukawa ◽  
Naoko Hattori ◽  
Naoko Iida ◽  
Hideyuki Takeshima ◽  
Masahiro Maeda ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Chromatin Immunoprecipitation ◽  
Therapeutic Target ◽  
Cancer Associated Fibroblasts ◽  
Promoting Effect ◽  
Gastric Cancer Cells ◽  
Potential Therapeutic Target ◽  
Active Enhancer ◽  
Serum Amyloid A1

Abstract Cancer-associated fibroblasts (CAFs) tend to have tumor-promoting capacity, and can provide therapeutic targets. Even without cancer cells, CAF phenotypes are stably maintained, and DNA methylation and H3K27me3 changes have been shown to be involved. Here, we searched for a potential therapeutic target in primary CAFs from gastric cancer and a mechanism for its dysregulation. Expression microarray using eight CAFs and seven non-CAFs (NCAFs) revealed that serum amyloid A1 (SAA1), which encodes an acute phase secreted protein, was second most upregulated in CAFs, following IGF2. Conditioned medium (CM) derived from SAA1-overexpressing NCAFs was shown to increase migration of gastric cancer cells compared to that from control NCAFs, and its tumor-promoting effect was comparable to that of CM from CAFs. In addition, increased migration of cancer cells by CM from CAFs was mostly canceled with CM from CAFs with SAA1 knockdown. Chromatin immunoprecipitation (ChIP)-quantitative PCR showed that CAFs had higher levels of H3K27ac, an active enhancer mark, in the promoter and the two far upstream regions of SAA1 than NCAFs. Also, BET bromodomain inhibitors, JQ1 and mivebresib, decreased SAA1 expression and tumor-promoting effects in CAFs, suggesting SAA1 upregulation by enhancer activation in CAFs. Our present data showed that SAA1 is a candidate therapeutic target from gastric CAFs and indicated that increased enhancer acetylation is important for its overexpression.

scholarly journals Identification of ARGLU1 as a potential therapeutic target for gastric cancer based on genome-wide functional screening data

EBioMedicine ◽  
2021 ◽  
Vol 69 ◽  
pp. 103436
Author(s):  
Fangyuan Li ◽  
Jianfang Li ◽  
Junxian Yu ◽  
Tao Pan ◽  
Beiqin Yu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Therapeutic Target ◽  
Functional Screening ◽  
Potential Therapeutic Target ◽  
Genome Wide

Downregulated SASH1 expression indicates poor clinical prognosis in gastric cancer

2018 ◽  
Vol 74 ◽  
pp. 83-91 ◽  
Author(s):  
Nan Zhou ◽  
Can Liu ◽  
Xudong Wang ◽  
Qinsheng Mao ◽  
Qin Jin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Clinical Prognosis ◽  
Poor Clinical Prognosis

scholarly journals MicroRNA-7 as a potential therapeutic target for aberrant NF-κB-driven distant metastasis of gastric cancer

2019 ◽  
Vol 38 (1) ◽  
Author(s):  
Tingbo Ye ◽  
Meihua Yang ◽  
Daochao Huang ◽  
Xin Wang ◽  
Bingqian Xue ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Distant Metastasis ◽  
Therapeutic Target ◽  
Potential Therapeutic Target

Abstract 3605: O-linked N-acetylglucosamine transferase as a potential therapeutic target for metastatic gastric cancer

2019 ◽  
Author(s):  
Joon Young Hur ◽  
Jeeyun Lee ◽  
Kyoung-Mee Kim ◽  
Sun-Ju Byeon ◽  
Inkyoung Lee ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Therapeutic Target ◽  
Metastatic Gastric Cancer ◽  
Potential Therapeutic Target ◽  
Acetylglucosamine Transferase

LAPTM4B-35 protein as a potential therapeutic target in gastric cancer

Tumor Biology ◽  
2014 ◽  
Vol 35 (12) ◽  
pp. 12737-12742 ◽  
Author(s):  
Hongying Zhang ◽  
Buxian Tian ◽  
Hongyu Yu ◽  
Hongyue Yao ◽  
Zhian Gao
Keyword(s):  
Gastric Cancer ◽  
Therapeutic Target ◽  
Potential Therapeutic Target

DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer

2011 ◽  
Vol 47 (12) ◽  
pp. 1817-1825 ◽  
Author(s):  
Kathrin Mutze ◽  
Rupert Langer ◽  
Felix Schumacher ◽  
Karen Becker ◽  
Katja Ott ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Therapeutic Target ◽  
Dna Methyltransferase ◽  
Predictive Biomarker ◽  
Dna Methyltransferase 1 ◽  
Potential Therapeutic Target ◽  
Methyltransferase 1

scholarly journals Expression of pyruvate dehydrogenase kinase-1 in gastric cancer as a potential therapeutic target

2012 ◽  
Vol 42 (1) ◽  
pp. 44-54 ◽  
Author(s):  
HOON HUR ◽  
YI XUAN ◽  
YOUNG BAE KIM ◽  
GWANG LEE ◽  
WOOYOUNG SHIM ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Pyruvate Dehydrogenase ◽  
Therapeutic Target ◽  
Pyruvate Dehydrogenase Kinase ◽  
Potential Therapeutic Target ◽  
Pyruvate Dehydrogenase Kinase 1
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