scholarly journals Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells

Oncotarget ◽  
2015 ◽  
Vol 6 (30) ◽  
pp. 28851-28866 ◽  
Author(s):  
Jen-Pi Tsai ◽  
Chien-Hsing Lee ◽  
Tsung-Ho Ying ◽  
Chu-Liang Lin ◽  
Chia-Liang Lin ◽  
...  
2005 ◽  
Vol 69 (5) ◽  
pp. 855-865 ◽  
Author(s):  
P.V. Lakshmana Rao ◽  
R. Jayaraj ◽  
A.S.B. Bhaskar ◽  
Om Kumar ◽  
R. Bhattacharya ◽  
...  

2006 ◽  
Vol 34 (03) ◽  
pp. 401-408 ◽  
Author(s):  
Jong-Seok Yoon ◽  
Jung-Chul Seo ◽  
Sang-Won Han

Pinelliae Rhizoma has been used traditionally in Korea to promote the liver Qi activity and the function of the digestive system. We investigated whether the Pinelliae Rhizoma herbal-acupuncture solution (PRHS) would induce cell-death on SNU-17, human cervical cancer cells. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to investigate the cytotoxicity of PRHS. The cell death was identified as apoptosis with 4, 6-diamidineo-2-phenylindole (DAPI) staining, and terminal deoxy-nucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL) assay. PRHS could induce apoptosis of SNU-17 via Bax-related caspase-3 activation. The expressions of both Bax, a pro-apoptotic gene, and caspase-3, an apoptotic gene, were increased. The results might provide the experimental data for the clinical use of Pinelliae Rhizoma on cervical cancer.


FEBS Letters ◽  
2001 ◽  
Vol 495 (1-2) ◽  
pp. 66-70 ◽  
Author(s):  
Kyoungho Suk ◽  
Yun-Hee Kim ◽  
Inik Chang ◽  
Ja Young Kim ◽  
Yun-Hee Choi ◽  
...  

2005 ◽  
Vol 118 (8) ◽  
pp. 1892-1900 ◽  
Author(s):  
Brigitte M.T. Hougardy ◽  
John H. Maduro ◽  
Ate G.J. van der Zee ◽  
Derk Jan A. de Groot ◽  
Fiona A.J. van den Heuvel ◽  
...  

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