Phospho-kinase profile of colorectal tumors guides in the selection of multi-kinase inhibitors

To suggest that the discovery of targetable driver mutations in many patients with advanced adenocarcinoma of the lung has completely transformed the work-up and therapeutic options for this disease would not be hyperbole. Although not curative, small-molecule tyrosine kinase inhibitors directed at oncogene-addicted tumors have led to significantly improved response rates compared with cytotoxic chemotherapy, with often manageable toxicities and better tolerance. However, the absence of reliable clinical predictors has made molecular testing essential to ensure that patients receive the proper medical management. We outline the many recent advances with regard to diagnosis and treatment of oncogene-addicted advanced nonsquamous non–small-cell lung cancer.

Download Full-text

Faculty Opinions recommendation of In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitors.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.6930960.7121058 ◽

2010 ◽

Author(s):

Dehua Pei ◽

Tao Liu

Keyword(s):

Small Molecule ◽

In Vitro Selection ◽

Kinase Inhibitors ◽

Small Molecule Library ◽

Selection Of

Download Full-text

Combined Liver and Multivisceral Resections

HPB Surgery ◽

10.1155/2014/976546 ◽

2014 ◽

Vol 2014 ◽

pp. 1-7 ◽

Cited By ~ 2

Author(s):

Martin de Santibañes ◽

Agustin Dietrich ◽

Eduardo de Santibañes

Keyword(s):

Liver Metastases ◽

Postoperative Morbidity ◽

Scientific Evidence ◽

Mortality Rates ◽

Careful Selection ◽

Colorectal Tumors ◽

Extensive Experience ◽

Electronic Search ◽

Selection Of Patients ◽

Selection Of

Background. Combined liver and multivisceral resections are infrequent procedures, which demand extensive experience and considerable surgical skills. Methods. An electronic search of literature related to this topic published before June 2013 was performed. Results. There is limited scientific evidence of the feasibility and clinical outcomes of these complex procedures. The majority of these cases are simultaneous resections of colorectal tumors with liver metastases. Combined liver and multivisceral resections can be performed with acceptable postoperative morbidity and mortality rates only in carefully selected patients. Conclusion. Lack of experience in these aggressive surgeries justifies a careful selection of patients, considering their comorbidities.

Download Full-text

A krónikus lymphocytás leukaemia korszerű molekuláris diagnosztikája és kezelése az új célzott terápiák korszakában

Orvosi Hetilap ◽

10.1556/650.2017.30870 ◽

2017 ◽

Vol 158 (41) ◽

pp. 1620-1629

Author(s):

Tímea Gurbity Pálfi ◽

Viktória Fésüs ◽

Csaba Bödör ◽

Zita Borbényi

Keyword(s):

Kinase Inhibitors ◽

Optimal Treatment ◽

Lymphoid Leukaemia ◽

Routine Diagnostics ◽

Asymptomatic Patients ◽

High Risk Disease ◽

Near Future ◽

Standard Risk ◽

Generation Sequencing ◽

Selection Of

Abstract: Chronic lymphoid leukaemia (CLL) has a heterogeneous clinical course depending on many clinical and molecular prognostic markers, which play an important role in the selection of the best treatment option. So far, TP53 disruption is the key prognostic and predictive factor assisting treatment decisions, especially in the era of novel therapies. Asymptomatic patients in early stages of the disease will still benefit from watchful waiting. In the frontline setting, chemoimmunotherapy is still the standard care in the majority of standard risk CLL patients. New classes of drugs like kinase inhibitors and BCL-2 inhibitors (ibrutinib, idelalisib and venetoclax) are the treatment of choice in CLL patients with relapsed/refractory disease, with the exception of high risk disease, where the optimal treatment is frontline ibrutinib monotherapy. In the near future, integrating next generation sequencing into the routine diagnostics would help the development of individual CLL patient management and to choose an optimal treatment strategy. Orv Hetil. 2017; 158(41): 1620–1629.

Download Full-text

Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors

Journal of Molecular Diagnostics ◽

10.1016/j.jmoldx.2013.03.001 ◽

2013 ◽

Vol 15 (4) ◽

pp. 415-453 ◽

Cited By ~ 296

Author(s):

Neal I. Lindeman ◽

Philip T. Cagle ◽

Mary Beth Beasley ◽

Dhananjay Arun Chitale ◽

Sanja Dacic ◽

...

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Cancer Patients ◽

Tyrosine Kinase Inhibitors ◽

Kinase Inhibitors ◽

Molecular Testing ◽

Lung Cancer Patients ◽

Selection Of

Download Full-text

Molecular Testing Guideline for Selection of Lung Cancer Patients for EGFR and ALK Tyrosine Kinase Inhibitors: Guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology: Erratum

Journal of Thoracic Oncology ◽

10.1097/jto.0000000000000002 ◽

2013 ◽

Vol 8 (10) ◽

pp. 1343 ◽

Cited By ~ 1

Keyword(s):

Lung Cancer ◽

Tyrosine Kinase ◽

Cancer Patients ◽

Tyrosine Kinase Inhibitors ◽

Molecular Pathology ◽

Kinase Inhibitors ◽

International Association ◽

Molecular Testing ◽

Lung Cancer Patients ◽

Selection Of

Download Full-text

Algorithm for clarifying diagnostics and intraluminal endoscopic removal of colorectal epithelial neoplasms

Koloproktologia ◽

10.33878/2073-7556-2021-20-1-17-22 ◽

2021 ◽

Vol 20 (1) ◽

pp. 17-22

Author(s):

D. V. Zavyalov ◽

S. V. Kashin ◽

P. V. Nesterov ◽

A. M. Nechipai ◽

V. V. Rybachkov ◽

...

Keyword(s):

Endoscopic Surgery ◽

Automatic System ◽

Malignant Tumors ◽

Correct Selection ◽

Detection Accuracy ◽

Depth Of Invasion ◽

Endoscopic Removal ◽

Colorectal Tumors ◽

Removal Technique ◽

Selection Of

Aim: to work out of a set of measures aimed for early detection of colorectal tumors and the choice of a method of endoscopic surgery.Patients and methods: a multimodal approach was used, which included two successive stages: the stage of assessing the depth of invasion of malignant colorectal epithelial tumors (1) and the stage of endoscopic surgery. The study included 974 patients, aged 67 (43-81) years. The algorithm of the systemic automatic approach to differentiate the depth of invasion of superficial malignant colorectal tumors has been worked out based on analysis of color pictures of colonoscopy (Colonoscopy Video Analysis). The results of use of automatic system were compared with experts’ assessment.Results: the application of the developed algorithm of the systemic automatic approach to differentiate the depth of invasion of malignant ENC has high detection accuracy – the total average detection accuracy when implementing this algorithm is 72.02. No significant differences with experts’ assessment were obtained. With endoscopic removal of malignant tumors with superficial invasion, the correct selection of patients based on the tumor size (up to 2.0 and over 2.0 cm) and the corresponding removal technique (mucosal resection or endoscopic submucosal dissection) are decisive.Conclusion: the automatic system of evaluation of tumor invasion depth has a high accuracy and gives a possibility to exclude false positive results.

Download Full-text