scholarly journals Epstein-Barr virus glycoprotein gH/gL antibodies complement IgA-viral capsid antigen for diagnosis of nasopharyngeal carcinoma

Oncotarget ◽  
2016 ◽  
Vol 7 (13) ◽  
pp. 16372-16383 ◽  
Author(s):  
Rui-Chen Li ◽  
Yong Du ◽  
Qiu-Yao Zeng ◽  
Lin-Quan Tang ◽  
Hua Zhang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Viral Capsid ◽  
Viral Capsid Antigen ◽  
Virus Glycoprotein ◽  
Barr Virus ◽  
Epstein Barr

scholarly journals Combination of Plasma MIF and VCA-IgA Improves the Diagnostic Specificity for Patients With Nasopharyngeal Carcinoma

2020 ◽  
Vol 19 ◽  
pp. 153303382093577
Author(s):  
Ning Xue ◽  
Shan Xing ◽  
Weiguo Ma ◽  
Jiahe Sheng ◽  
Zhiliang Huang ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Migration Inhibitory Factor ◽  
Macrophage Migration Inhibitory Factor ◽  
Epstein Barr Virus ◽  
Inhibitory Factor ◽  
Viral Capsid ◽  
Macrophage Migration ◽  
Viral Capsid Antigen ◽  
Barr Virus ◽  
Epstein Barr

Introduction: The purpose of this study is to evaluate the diagnostic value of macrophage migration inhibitory factor in patients with nasopharyngeal carcinoma. Materials and Methods: The expression levels of macrophage migration inhibitory factor in nasopharyngeal carcinoma cell lines, tumor tissues, and plasma were measured by real-time polymerase chain reaction, Western blotting, enzyme-linked immunosorbent assay, and immunohistochemistry. Plasma Epstein-Barr virus viral capsid antigen was determined by immunoenzymatic techniques. Results: Both the messenger RNA and protein expression levels of macrophage migration inhibitory factor were upregulated in nasopharyngeal carcinoma cell lines and nasopharyngeal carcinoma tissues. Macrophage migration inhibitory factor in plasma was significantly elevated in patients with nasopharyngeal carcinoma compared to Epstein-Barr virus viral capsid antigen–negative and Epstein-Barr virus viral capsid antigen–positive healthy donors. The combination of macrophage migration inhibitory factor and Epstein-Barr virus viral capsid antigen was better for diagnosing nasopharyngeal carcinoma (area under receiver operating characteristic curve = 0.925, 95% CI: 0.898-0.951) than macrophage migration inhibitory factor (area under receiver operating characteristic curve = 0.778, 95% CI: 0.732-0.824) and Epstein-Barr virus viral capsid antigen. Combining macrophage migration inhibitory factor and Epstein-Barr virus viral capsid antigen had higher specificity (82.40% vs 69.96%) and higher positive predictive value (79.17% vs 67.44%) without an obvious reduction in sensitivity (95.25%) compared to Epstein-Barr virus viral capsid antigen alone. Macrophage migration inhibitory factor was highly expressed in nasopharyngeal carcinoma cell lines, whereas it was not associated with Epstein-Barr virus infection. The level of macrophage migration inhibitory factor in plasma was not related to the titer of Epstein-Barr virus viral capsid antigen. Conclusion: The combination of macrophage migration inhibitory factor and Epstein-Barr virus viral capsid antigen increases the specificity and positive predictive value of detecting nasopharyngeal carcinoma and improves the diagnostic accuracy of nasopharyngeal carcinoma in high-risk individuals.

scholarly journals Immunoglobulin A against viral capsid antigen of Epstein-Barr virus and indirect mirror examination of the nasopharynx in the detection of asymptomatic nasopharyngeal carcinoma

Cancer ◽  
1992 ◽  
Vol 69 (1) ◽  
pp. 3-7 ◽  
Author(s):  
Zong Yong-Sheng ◽  
Jonathan S. T. Sham ◽  
M. H. Ng ◽  
Ou Xing-Tai ◽  
Guo Yuan-Qing ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epstein Barr Virus ◽  
Immunoglobulin A ◽  
Viral Capsid ◽  
Viral Capsid Antigen ◽  
Barr Virus ◽  
Epstein Barr

Increased incidence of IgA antibodies to the epstein-barr virus-associated viral capsid antigen and early antigens in patients with chronic lymphocytic leukemia

1986 ◽  
Vol 38 (1) ◽  
pp. 55-59 ◽  
Author(s):  
Gottfried Döucen ◽  
Klaus J. Bross ◽  
Thomas Hecht ◽  
Wolfram Brugger ◽  
Georg W. Löhr ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Epstein Barr Virus ◽  
Lymphocytic Leukemia ◽  
Viral Capsid ◽  
Viral Capsid Antigen ◽  
Barr Virus ◽  
Iga Antibodies ◽  
Epstein Barr

Comparison of immunofluorescence assay and multiplexed microparticle-based immunoassay for detecting Epstein-Barr virus viral capsid antigen antibodies

2008 ◽  
Vol 148 (1-2) ◽  
pp. 300-302 ◽  
Author(s):  
Aysin Zeytinoglu ◽  
Imre Altuglu ◽  
Eylem Karatas ◽  
Ruchan Yazan Sertoz
Keyword(s):  
Epstein Barr Virus ◽  
Immunofluorescence Assay ◽  
Viral Capsid ◽  
Viral Capsid Antigen ◽  
Barr Virus ◽  
Epstein Barr

Development of a time-resolved fluoroimmunoassay for Epstein–Barr virus viral capsid antigen IgA antibody in human serum

2015 ◽  
Vol 222 ◽  
pp. 16-21 ◽  
Author(s):  
Qian-Ni Liang ◽  
Pei-Qi Chen ◽  
Tian-Cai Liu ◽  
Jian-Wei Zhou ◽  
Juan-Juan Chen ◽  
...  
Keyword(s):  
Human Serum ◽  
Epstein Barr Virus ◽  
Viral Capsid ◽  
Viral Capsid Antigen ◽  
Time Resolved ◽  
Barr Virus ◽  
Iga Antibody ◽  
Epstein Barr

scholarly journals Transient Headache and Neurological Deficits with Cerebrospinal Fluid Lymphocytosis Associated with IgM Antibodies to the Epstein-Barr Virus Viral Capsid Antigen

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Kossivi Apetse ◽  
Ludovic Breynaert ◽  
Chloe Butaud ◽  
Albert Beschet ◽  
Karine Blanc-Lasserre ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Epstein Barr Virus ◽  
Immunological Response ◽  
Neurological Deficits ◽  
Viral Capsid ◽  
Viral Agent ◽  
Viral Capsid Antigen ◽  
Barr Virus ◽  
Igm Antibodies ◽  
Epstein Barr

Some authors have suggested that the syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL) results from an immunological response directed against a viral agent. Here we report a case of HaNDL in an immunocompetent 19-year-old male that could support this hypothesis.

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