scholarly journals Cancer-associated fibroblasts promote non-small cell lung cancer cell invasion by upregulation of glucose-regulated protein 78 (GRP78) expression in an integrated bionic microfluidic device

Oncotarget ◽  
2016 ◽  
Vol 7 (18) ◽  
pp. 25593-25603 ◽  
Author(s):  
Ting Yu ◽  
Zhe Guo ◽  
Hui Fan ◽  
Jing Song ◽  
Yuanbin Liu ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Small Cell ◽  
Cancer Associated Fibroblasts ◽  
Cancer Cell Invasion ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Glucose Regulated Protein

scholarly journals Autophagic secretion of HMGB1 from cancer-associated fibroblasts promotes metastatic potential of non-small cell lung cancer cells via NFκB signaling

2021 ◽  
Vol 12 (10) ◽  
Author(s):  
Yinghui Ren ◽  
Limin Cao ◽  
Limin Wang ◽  
Sijia Zheng ◽  
Qicheng Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Tumor Cells ◽  
Cancer Cell ◽  
Cell Invasion ◽  
Small Cell ◽  
Cancer Associated Fibroblasts ◽  
Cancer Cell Invasion ◽  
Lung Cancer Cell ◽  
Small Cell Lung

AbstractTumor progression requires the communication between tumor cells and tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are major components of stromal cells. CAFs contribute to metastasis process through direct or indirect interaction with tumor cells; however, the underlying mechanism is largely unknown. Here, we reported that autophagy was upregulated in lung cancer-associated CAFs compared to normal fibroblasts (NFs), and autophagy was responsible for the promoting effect of CAFs on non-small cell lung cancer (NSCLC) cell migration and invasion. Inhibition of CAFs autophagy attenuated their regulation on epithelial–mesenchymal transition (EMT) and metastasis-related genes of NSCLC cells. High mobility group box 1 (HMGB1) secreted by CAFs mediated CAFs’ effect on lung cancer cell invasion, demonstrated by using recombinant HMGB1, HMGB1 neutralizing antibody, and HMGB1 inhibitor glycyrrhizin (GA). Importantly, the autophagy blockade of CAFs revealed that HMGB1 release was dependent on autophagy. We also found HMGB1 was responsible, at least in part, for autophagy activation of CAFs, suggesting CAFs remain active through an autocrine HMGB1 loop. Further study demonstrated that HMGB1 facilitated lung cancer cell invasion by activating the NFκB pathway. In a mouse xenograft model, the autophagy specific inhibitor chloroquine abolished the stimulating effect of CAFs on tumor growth. These results elucidated an oncogenic function for secretory autophagy in lung cancer-associated CAFs that promotes metastasis potential, and suggested HMGB1 as a novel therapeutic target.

RETRACTED: The miR-599 promotes non-small cell lung cancer cell invasion via SATB2

2017 ◽  
Vol 485 (1) ◽  
pp. 35-40 ◽  
Author(s):  
Wenjun Tian ◽  
Guanghai Wang ◽  
Yiqing Liu ◽  
Zhenglan Huang ◽  
Caiqing Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cell ◽  
Cell Lung Cancer ◽  
Cell Invasion ◽  
Small Cell ◽  
Cancer Cell Invasion ◽  
Lung Cancer Cell ◽  
Small Cell Lung

FPPS mediates TGF-β1-induced non-small cell lung cancer cell invasion and the EMT process via the RhoA/Rock1 pathway

2018 ◽  
Vol 496 (2) ◽  
pp. 536-541 ◽  
Author(s):  
Lin Lin ◽  
Ming Li ◽  
Lei Lin ◽  
Xiaolin Xu ◽  
Gening Jiang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cell ◽  
Cell Lung Cancer ◽  
Cell Invasion ◽  
Small Cell ◽  
Cancer Cell Invasion ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Tgf Β1

CCR1 knockdown suppresses human non-small cell lung cancer cell invasion

2008 ◽  
Vol 135 (5) ◽  
pp. 695-701 ◽  
Author(s):  
Chang-Li Wang ◽  
Bing-Sheng Sun ◽  
Yong Tang ◽  
Hong-Qing Zhuang ◽  
Wei-Zhi Cao
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cell ◽  
Cell Lung Cancer ◽  
Cell Invasion ◽  
Small Cell ◽  
Cancer Cell Invasion ◽  
Lung Cancer Cell ◽  
Small Cell Lung

Epigenetic downregulated ITGBL1 promotes non-small cell lung cancer cell invasion through Wnt/PCP signaling

Tumor Biology ◽  
2015 ◽  
Vol 37 (2) ◽  
pp. 1663-1669 ◽  
Author(s):  
Xin Gan ◽  
Zhentian Liu ◽  
Bo Tong ◽  
Jianying Zhou
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cell ◽  
Cell Lung Cancer ◽  
Cell Invasion ◽  
Small Cell ◽  
Cancer Cell Invasion ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Pcp Signaling

scholarly journals TIAM2 Enhances Non-small Cell Lung Cancer Cell Invasion and Motility

2013 ◽  
Vol 14 (11) ◽  
pp. 6305-6309 ◽  
Author(s):  
Zheng-Yuan Zhao ◽  
Chen-Guang Han ◽  
Jun-Tao Liu ◽  
Chang-Lei Wang ◽  
Yi Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cell ◽  
Cell Lung Cancer ◽  
Cell Invasion ◽  
Small Cell ◽  
Cancer Cell Invasion ◽  
Lung Cancer Cell ◽  
Small Cell Lung

scholarly journals Erratum to: Epigenetic downregulated ITGBL1 promotes non-small cell lung cancer cell invasion through Wnt/PCP signaling

Tumor Biology ◽  
2016 ◽  
Vol 37 (6) ◽  
pp. 8461-8461
Author(s):  
Xin Gan ◽  
Zhentian Liu ◽  
Jianying Zhou ◽  
Bo Tong
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cell ◽  
Cell Lung Cancer ◽  
Cell Invasion ◽  
Small Cell ◽  
Cancer Cell Invasion ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Pcp Signaling

Retraction notice to “The miR-599 promotes non-small cell lung cancer cell invasion via SATB2” [Biochem. Biophys. Res. Commun. 485/1 (2017) 35–40]

2019 ◽  
Vol 515 (4) ◽  
pp. 733
Author(s):  
Wenjun Tian ◽  
Guanghai Wang ◽  
Yiqing Liu ◽  
Zhenglan Huang ◽  
Caiqing Zhang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cancer Cell ◽  
Cell Lung Cancer ◽  
Cell Invasion ◽  
Small Cell ◽  
Cancer Cell Invasion ◽  
Lung Cancer Cell ◽  
Small Cell Lung ◽  
Retraction Notice
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