Metal sources and ore genesis of the Wusihe Pb-Zn deposit in Sichuan, China: New evidence from in-situ S and Pb isotopes

Sustainable use of wildlife has become equated with exploitation of animal products (meat, skin or feathers) and/or removal of wild progenitors into the pet trade. This consumption of the wildlife is therefore largely ex situ and so removes nutrients and energy from the rangelands. Demand for lethal or a removal action is often driven by the severity of the perceived conflict between the wildlife and other enterprises, especially agriculture, rather than for the resulting products. Such uses also raise community concerns about humane treatment of animals and a valuing of the natural heritage. Wildlife-based tourism, as part of the valuable and growing nature-based or ecotourism industry in Australia, is an in situ use that may be a more ecologically sustainable and economically twble option for use of rangeland wildlife. This paper examines these possibilities and their problems with a focus on the commercial kangaroo industry and the use of arid-zone mammals, birds and reptiles for pets. It provides new evidence that wildlife-tourism based on free-living kangaroos in the rangelands is both feasible and in demand. This industry should be given advocacy in the on-going debate on the management and future of the rangelands. Key words: kangaroos, wildlife management, wildlife tourism, game harvesting

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Abstract 426: Laminin Downregulation Facilitates Cardiomyocyte Coupling in situ to Increase Contractile Function

Circulation Research ◽

10.1161/res.119.suppl_1.426 ◽

2016 ◽

Vol 119 (suppl_1) ◽

Author(s):

Ayla Sessions ◽

Gaurav Kaushik ◽

Adam Engler

Keyword(s):

Basement Membrane ◽

Contractile Function ◽

Current Model ◽

Model Systems ◽

Model Organisms ◽

Muscle Physiology ◽

Heart Tube ◽

Age Related ◽

New Evidence

Aging is associated with extensive remodeling of the heart, including basement membrane extracellular matrix (ECM) components that surround cardiomyocytes. Remodeling is thought to contribute to impaired cardiac mechanotransduction, but the contribution of specific basement membrane ECM components to age-related cardiac remodeling is unclear, owing to current model systems being complex and slow to age. To investigate the effect of basement membrane remodeling on mechanical function in genetically tractable, rapidly aging, and simple model organisms, we employed Drosophila melanogaster, which has a simple trilayered heart tube composed of only basement membrane ECM. We observed differential regulation of collagens between laboratory Drosophila strains , i.e. yellow-white ( yw ) and white-1118 ( w 1118 ), leading to changes in muscle physiology, which were linked to severity of dysfunction with age. Therefore, we sought to understand the extent to which basement membrane ECM modulates lateral cardiomyocyte coupling and contractile function during aging. Cardiac-restricted knockdown of ECM genes Pericardin , Laminin A , and Viking in Drosophila prevented age-associated heart tube restriction and increased contractility, even under viscous load. Most notably, reduction of Laminin A expression decreased levels of other genes that co-assemble in ECM, leading to overall preservation of contractile velocity and extension of median organismal lifespan by 3 weeks or 39%. These data provide new evidence of a direct link between basement membrane ECM homeostasis, contractility, and maintenance of lifespan.

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