In this follow-up panel, we discuss what we have learned over the last year about responding to an epidemic or pandemic that has demonstrated a level of transmission unprecedented in the modern era. Two medical doctors that have worked on the front of this pandemic share their experiences transitioning from the “sharp end” of the response. Decisions about how to mitigate hazards have occurred at the personal, institutional, and health policy levels, in real-time, with frequent adaptation, and often in advance of concrete evidence. Over the course of the pandemic, hospital systems revised existing protocols to manage perceived risks in real time using emerging information from other centers. With the introduction of vaccines, there is a new type of risk perception. Is the vaccine perceived to be safe? Is there a disparity in perception among different population groups? That said, analyses are also complicated by emerging viral mutations with unclear implications. What factors increase or decrease public compliance with precautions? How are US education policymakers deciding about face-to-face classroom instruction? This panel includes a warnings expert, an expert on education policy, and two practicing physicians.