scholarly journals Treatment of hypertension with a very low dose of antibody to C-fragment of type 1 angiotensin II receptor

2008 ◽  
Vol 14 (3) ◽  
pp. 236-238
Author(s):  
V. Petrov ◽  
A. Kolosova ◽  
S. Tarasov ◽  
L. V . Sabanov ◽  
M. V. Kachanova ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Low Dose ◽  
Blood Pressure Lowering ◽  
Angiotensin Ii Receptor ◽  
Blood Pressure Lowering Effect ◽  
Night Time ◽  
Hypertensive Patients ◽  
Treatment Of Hypertension ◽  
Pressure Lowering

The study documented blood pressure lowering effect according to ABMP data in 50 hypertensive patients receiving antibodies to C-end fragment to AT1 receptors for 3 months. (Cardos). The drug was well-tolerated and showeed 24-hour significant decrease of blood pressure at day-time as well as at night-time.

scholarly journals Daily inhalation of hydrogen gas has a blood pressure-lowering effect in a rat model of hypertension

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Kazuhisa Sugai ◽  
Tomoyoshi Tamura ◽  
Motoaki Sano ◽  
Shizuka Uemura ◽  
Masahiko Fujisawa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Parasympathetic Nervous System ◽  
Pressure Control ◽  
Hydrogen Gas ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Night Time ◽  
Lowering Effect ◽  
Pressure Lowering

AbstractA recent clinical study demonstrated that haemodialysis with a dialysate containing hydrogen (H2) improves blood pressure control in end-stage kidney disease. Herein, we examined whether H2 has a salutary effect on hypertension in animal models. We subjected 5/6 nephrectomised rats to inhalation of either H2 (1.3% H2 + 21% O2 + 77.7% N2) or control (21% O2 + 79% N2) gas mixture for 1 h per day. H2 significantly suppressed increases in blood pressure after 5/6 nephrectomy. The anti-hypertensive effect of H2 was also confirmed in rats in a stable hypertensive state 3 weeks after nephrectomy. To examine the detailed effects of H2 on hypertension, we used an implanted telemetry system to continuously monitor blood pressure. H2 exerted an anti-hypertensive effect not only during daytime rest, but also during night-time activities. Spectral analysis of blood pressure variability revealed that H2 improved autonomic imbalance, namely by suppressing the overly active sympathetic nervous system and augmenting parasympathetic nervous system activity; these effects co-occurred with the blood pressure-lowering effect. In conclusion, 1-h daily exposure to H2 exerts an anti-hypertensive effect in an animal model of hypertension.

Blood pressure-lowering effect of melatonin in type 1 diabetes

2004 ◽  
Vol 36 (4) ◽  
pp. 262-266 ◽  
Author(s):  
Anita Cavallo ◽  
Stephen R. Daniels ◽  
Lawrence M. Dolan ◽  
Judy A. Bean ◽  
Jane C. Khoury
Keyword(s):  
Blood Pressure ◽  
Type 1 Diabetes ◽  
Blood Pressure Lowering ◽  
Blood Pressure Lowering Effect ◽  
Lowering Effect ◽  
Pressure Lowering
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