scholarly journals HYPERTENSION IN THYROTOXICOSIS AND ITS IMPACT ON LEFT VENTRICULAR HYPERTROPHY

2013 ◽  
Vol 19 (3) ◽  
pp. 237-241 ◽  
Author(s):  
A. Yu. Babenko ◽  
E. N. Grineva ◽  
V. N. Solntsev
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Left Ventricular Hypertrophy ◽  
Systolic Hypertension ◽  
Ventricular Hypertrophy ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Left Ventricular ◽  
High Rate ◽  
Cardiovascular Prognosis

Objective. We present the results of the study assessing the frequency and character of hypertension in thyrotoxicosis, and its impact on left ventricular remodeling and cardiovascular prognosis.Results and conclusions. Our data demonstrated that hypertension, and predominantly systolic hypertension, is highly prevalent in thyrotoxicosis and affects left ventricular remodeling. All normotensive patients developed only eccentric left ventricular hypertrophy (LVH). The prevalence of LVH, and of its concentric forms increases with the elevation of blood pressure. Concentric LVH is associated with the high rate of atrial fi brillation and heart failure.

scholarly journals The Peculiarity of Left Ventricular Remodeling in Patients with Hypertension Developing Acute Myocardial Infarction

2021 ◽  
Vol 6 (1) ◽  
pp. 153-159
Author(s):  
I. M. Fushtey ◽  
◽  
E. V. Sid’ ◽  
V. О. Ivashchuk
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Ventricular Myocardium ◽  
Left Ventricular ◽  
Left Ventricular Myocardium ◽  
St Segment Elevation

The purpose of the study was to determine the peculiarity of left ventricular remodeling among patients with hypertension developing acute myocardial infarction. Material and methods. The results of the study are based on the data of a comprehensive examination of 477 patients with coronary artery disease: 280 patients with STEMI (ST-segment elevation myocardial infarction), 91 patients with NSTEMI (non ST-segment elevation myocardial infarction) and the control group consisted of 76 patients with exertional angina (II and III functional class for 38 people). The examination of patients was carried out in the period from 2015 to January 2018 on the basis of the Regional Medical Center for Cardiovascular Diseases of the Zaporozhye Regional Council. All patients (n=477) were comparable in age, social status and gender. The proportion of patients with hypertension was comparable between the groups and amounted to 255 (91.1%) patients with STEMI, 86 (94.5%) with NSTEMI, and 71 (93.4%) patients with stable coronary artery disease. Results and discussion. The development of left ventricular hypertrophy is a long-term process in hypertensive patients. At first, there is a change in the geometry of the left ventricle, since during systole the ventricle tends to take a spherical shape. Further, dilatation of cavities, hypertrophy and an increase in the mass of the left ventricular myocardium, replacement of the myocardium with fibrous tissue develop. Whereas in patients with acute myocardial infarction, due to acute myocardial ischemia, thickening of the myocardial wall is associated with interstitial edema occurs rather quickly. These important factors make it difficult to compare different studies and to reliably identify patients with true left ventricular hypertrophy. Therefore, left ventricular myocardium mass index should be determined as early as possible in patients with hypertension after the development of acute myocardial infarction, in order to interpret the obtained data. Сonclusion. Ischemic heart disease is often associated with essential hypertension, more than 90% of patients with acute myocardial infarction developed essential hypertension. It was determined that eccentric and concentric left ventricular hypertrophy prevailed among those examined on the first day of hospitalization and was due to the presence of hypertension

scholarly journals Aortic stenosis with abnormal eccentric left ventricular remodeling secondary to hypothyroidism in a Bourdeaux Mastiff

2017 ◽  
Vol 47 (9) ◽  
Author(s):  
Guilherme Augusto Minozzo ◽  
Simone Tostes de Oliveira Stedile ◽  
Marlos Gonçalves Sousa
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Aortic Stenosis ◽  
Ventricular Hypertrophy ◽  
Ventricular Remodeling ◽  
Left Ventricular Remodeling ◽  
Skin Lesions ◽  
Left Ventricular ◽  
The Body ◽  
Congenital Aortic Stenosis ◽  
Eccentric Hypertrophy

ABSTRACT: This paper describes a case of congenital aortic stenosis with eccentric left ventricular hypertrophy associated with hypothyroidism in a 1-year-old Bourdeaux Mastiff dog. The dog had ascites, apathy, alopecic and erythematous skin lesions in different parts of the body. A two-dimensional echocardiogram revealed aortic valve stenosis, with poststenotic dilation in the ascending aorta. The same exam showed eccentric hypertrophy and dilation of the left ventricle during systole and diastole. Aortic stenosis usually results in concentric left ventricular hypertrophy instead of eccentric hypertrophy; and therefore, this finding was very unusual. Hypothyroidism, which is uncommon in young dogs, may be incriminated as the cause of ventricular dilation, making this report even more interesting. Because hypothyroidism would only result in dilatation, the eccentric hypertrophy was attributed to pressure overload caused by aortic stenosis. Thus, cardiac alterations of this case represent a paradoxical association of both diseases.

scholarly journals Prevention of heart failure in hypertension – disentangling the role of evolving left ventricular hypertrophy and blood pressure lowering: the ALLHAT study

2019 ◽  
Author(s):  
Kyle Johnson ◽  
Suzanne Oparil ◽  
Barry R. Davis ◽  
Larisa G. Tereshchenko
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
Cox Regression ◽  
Left Ventricular ◽  
Lipid Lowering ◽  
Antihypertensive Medications ◽  
Pressure Lowering

AbstractBackgroundHypertension (HTN) is a known risk factor for heart failure (HF), possibly via the mechanism of cardiac remodeling and left ventricular hypertrophy (LVH). We studied how much blood pressure (BP) change and evolving LVH contribute to the effect that lisinopril, doxazosin, amlodipine have on HF compared to chlorthalidone.MethodsWe conducted causal mediation analysis of Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) data. ALLHAT participants with available serial ECGs and BP measurements were included (n=29,892; mean age 67±4 y; 32% black; 56% men): 11,008 were randomized to chlorthalidone, 5,967 – to doxazosin, 6,593 – to amlodipine, and 6,324 – to lisinopril. Evolving ECG-LVH, and BP-lowering served as mediators. Incident symptomatic HF was the primary outcome. Linear regression (for mediator) and logistic regression (for outcome) models were adjusted for mediator-outcome confounders (demographic and clinical characteristics known to be associated both with both LVH/HTN and HF).ResultsA large majority of participants (96%) had ECG-LVH status unchanged; 4% developed evolving ECG-LVH. On average, BP decreased by 11/7 mmHg. In adjusted Cox regression analyses, progressing ECG-LVH [HR 1.78(1.43-2.22)], resolving ECG-LVH [HR 1.33(1.03-1.70)], and baseline ECG-LVH [1.17(1.04-1.31)] carried risk of incident HF. After full adjustment, evolving ECG-LVH mediated 4% of the effect of doxazosin on HF. Systolic BP-lowering mediated 12% of the effect of doxazosin, and diastolic BP-lowering mediated 10% effect of doxazosin, 7% effect of amlodipine, and borderline 9% effect of lisinopril on HF.ConclusionsEvolving ECG-LVH and BP change account for 4-13% of the mechanism by which antihypertensive medications prevent HF.

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