scholarly journals Degenerative Disc Disease: A Review of Cell Technologies and Stem Cell Therapy

2016 ◽  
Vol 1 (4) ◽  
pp. 6-10
Author(s):  
Kaveh Haddadi ◽  
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Stem Cell Therapy ◽  
Degenerative Disc Disease ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Cell Technologies

Regeneration Potential of Stem Cell in the Treatment of IVD

2021 ◽  
Vol 9 (8) ◽  
pp. 3022-3036
Author(s):  
Riya Bhanushali
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Cell Therapy ◽  
Intervertebral Disc ◽  
Stem Cell Therapy ◽  
Degenerative Disc Disease ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Potential Use

Abstract: Degenerative disc disease is a prevalent musculoskeletal disorder in which damaged spinal discs cause pain upon aging, accidental injuries. Spinal discs connect adjacent vertebrae and help in maintaining mobility, flexibility and rotation of spinal cord. Spinal discs also act as shock absorbers. Intervertebral disc (IVD) degeneration is often associated with low back and neck pain, which accounts for disability worldwide. Physical therapy, spinal fusion surgeries reduce severity and symptoms of degenerative disc disease but they are not complete cure for this disease. Current preclinical studies show that mesenchymal stem cells have the capacity to repair degenerative disks by differentiation to chondrocyte-like cells, which produce proteoglycans and type II collagen. Mesenchymal stem cells (MSCs) isolated from bone marrow (BM-MSCs), adipose tissue (AD-MSCs) and umbilical cord (UC-MSCs) show potential use in cartilage and intervertebral disc (IVD) repair. Regenerative medicine and stem cell therapy hold great promise for treatment of intervertebral disc (IVD) disease. This review discusses about progression of degenerative disc disease, various types of stem cells, potential use of mesenchymal stem cells (MSCs) and embryonic stem cells (ESCs) for the treatment of degenerative disc disease. This review also focuses upon challenges encountered by the application of stem cell therapy for treating degenerative disc disease as well as future perspectives. Keywords: IVD, Stem cell therapy, AF & NP cells, MSCs, Scaffolds, Cell therapy

scholarly journals A comparative study of mesenchymal stem cell transplantation and NTG-101 molecular therapy to treat degenerative disc disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ajay Matta ◽  
Muhammad Zia Karim ◽  
Hoda Gerami ◽  
Bettina Benigno ◽  
W. Mark Erwin
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Degenerative Disc Disease ◽  
Molecular Therapy ◽  
Disc Disease ◽  
Mesenchymal Stem Cell Transplantation ◽  
Degenerative Disc

AbstractCellular replacement therapy using mesenchymal stem cells (MSCs) and/or the delivery of growth factors are at the forefront of minimally invasive biological treatment options for Degenerative Disc Disease (DDD). In this study, we compared the therapeutic potential of a novel drug candidate, NTG-101 to MSCs, including rat cartilage derived stem cells (rCDSCs), bone marrow stem cells (rBMSCs) and human Umbilical Cord Derived Mesenchymal Stem Cells (hUCMSCs) for the treatment of DDD. We induced DDD using a validated image-guided needle puncture injury in rat-tail IVDs. Ten weeks post-injury, animals were randomized and injected with MSCs, NTG-101 or vehicle. At the end of the study, histological analysis of the IVD-Nucleus Pulposus (NPs) injected with NTG-101 or rCDSCs showed a healthy or mild degenerative phenotype in comparison to vehicle controls. Immunohistochemical analysis revealed strong expression of aggrecan, collagen 2, brachyury and Oct4 in IVD-NPs injected with NTG-101. Our results also demonstrated suppression of inflammation induced p38 and NFκB resulting in inhibition of catabolic genes, but activation of Smad-2/3, Erk-1/2 and Akt-dependent signaling inducing anabolic genes in IVD-NP on treatment with NTG-101. In conclusion, a single injection of NTG-101 into the degenerative disc demonstrated superior benefits compared to stem cell transplantation.

scholarly journals Stem cell therapy for degenerative disc disease: A review

2021 ◽  
Vol 15 (3) ◽  
pp. 238-248
Author(s):  
Shreya SK ◽  
Pushpa Agrawal ◽  
Shivandappa
Keyword(s):  
Stem Cells ◽  
Cell Therapy ◽  
Degenerative Disc Disease ◽  
Current Status ◽  
Disc Disease ◽  
Pilot Studies ◽  
Surgical Interventions ◽  
Degenerative Disc ◽  
Different Types

Degenerative Disc Disease (DDD) is a prevalent musculoskeletal disorder associated with lower back pain that typically occurs with age but can also be precipitated by other factors. At present, the available treatments such as physical therapy, analgesics, anti-inflammatory drugs, and surgical interventions are aimed at addressing the symptoms of the disease but not the degeneration process. Among the various biological disc repair therapies, cell therapy has gained interest as it offers a disc regenerative potential while being minimally invasive. Stem cells have the unique property of differentiating into chondrocytes (specialized cells found in cartilage) that resemble Nucleus Pulposus (NP) cells of the disc. Therefore, stem cells can be used to replace the lost NP cells in the degenerated disc. This reduces inflammation and helps in the regeneration of the degenerated disc. In vitro studies, several animal-based studies, and a few human pilot studies have demonstrated safety and efficacy in the treatment of DDD with different types of Mesenchymal Stem Cells (MSCs), Induced Pluripotent Stem Cells (IPSCs), and Intervertebral Disc Stem Cells (IVDSCs). This review aims to address the current status, recent advancements, and different types of stem cells in degenerated disc therapy.

scholarly journals A Combinational Approach Using Cell Therapy, Tissue Engineering, and Distracting Device for the Treatment of Degenerative Disc Disease

2021 ◽  
Vol 7 (1) ◽  
pp. 1-5
Author(s):  
G Rasul Chaudhry ◽  
Keyword(s):  
Tissue Engineering ◽  
Cell Therapy ◽  
Intervertebral Disc ◽  
Degenerative Disc Disease ◽  
Organization Structure ◽  
Structure And Function ◽  
Disc Disease ◽  
Degenerative Disc ◽  
Vertebral Bodies ◽  
And Function

The Intervertebral Disc (IVD) is a fibrocartilaginous tissue instrumental in spine flexibility, allowing for the bending and twisting motion between vertebral bodies. Degenerative Disc Disease (DDD) results from the complex and chronic deterioration in IVD organization, structure, and function

scholarly journals 655. Comparative Viability, Potency and In Vivo Efficacy of a Fresh or Cryopreserved Cell Therapy for the Treatment of Degenerative Disc Disease

2015 ◽  
Vol 23 ◽  
pp. S261 ◽  
Author(s):  
Lara I. Silverman ◽  
Galina Dulatova ◽  
Kavita Gupta ◽  
Terry Tandeski ◽  
Chinne Chintalacharuvu ◽  
...  
Keyword(s):  
Cell Therapy ◽  
Degenerative Disc Disease ◽  
Disc Disease ◽  
In Vivo Efficacy ◽  
Degenerative Disc ◽  
Cryopreserved Cell

Mesenchymanl Stem Cell Based Intradiscal Gene Therapy: Therapeutic Implication in Degenerative Disc Disease

2004 ◽  
Vol 11 (2) ◽  
pp. 67
Author(s):  
Hyang Kim ◽  
Un-Hye Kwon ◽  
Kwang-Il Lee ◽  
Ki-Hong Song ◽  
Sung-Yeop Shin ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Stem Cell ◽  
Degenerative Disc Disease ◽  
Therapeutic Implication ◽  
Disc Disease ◽  
Degenerative Disc
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