CORRELATION BETWEEN METABOLIC SYNDROME AND SERUM URIC ACID IN THE OFFICE WORKERS OF A BUMN COMPANY IN SURABAYA, INDONESIA

Background: Metabolic syndrome is a cluster of risk factor which consists of central obesity, hypertriglyceride, low High Density Lipoprotein (HDL) level, hypertension, and hyperglycemia. Its incidence among the office workers is increasing. Uric acid is often associated with cardiovascular disease while risk factor of cardiovascular disease is associated with metabolic syndrome. Objective: To analyze correlation between metabolic syndrome and serum uric acid level in office workers. Materials and Methods: This study used medical record of health examination of PT Wijaya Karya Divisi IV male office workers aged of 20 – 60 years. The data taken consisted of abdominal circumference, triglyceride level, HDL level, fasting blood glucose level, blood pressure, and serum uric acid levels. The diagnostic criterion of metabolic syndrome used in this study was National Cholesterol Education Program’s Adult Treatment Panel III (NCEP ATP III) that had been modified for Asians. The correlation of metabolic syndrome and serum uric acid level was analyzed with chi-square test with IBM SPSS Statistic 20 application. Results: There was no significant correlation (p=0.598) between metabolic syndrome and serum uric acid leves in male office workers of PT Wijaya Karya Divisi IV. Conclusion: Metabolic syndrome and serum uric acid level among male office workers of PT Wijaya Karya Division IV had no correlation.

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NO CORRELATION BETWEEN METABOLIC SYNDROME AND SERUM URIC ACID IN THE OFFICE WORKERS OF BUMN COMPANY IN SURABAYA

Majalah Biomorfologi ◽

10.20473/mbiom.v31i1.2021.13-20 ◽

2021 ◽

Vol 31 (1) ◽

pp. 13

Author(s):

Jihan Jauza Fairuz ◽

Dewi Ratna Sari ◽

Soebagijo Adi Soelistijo

Keyword(s):

Cardiovascular Disease ◽

Metabolic Syndrome ◽

Uric Acid ◽

Risk Factor ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Serum Uric Acid Level ◽

Office Workers ◽

Abdominal Circumference

Background: Metabolic syndrome is a cluster of risk factor which consists of central obesity, hypertriglyceride, low High Density Lipoprotein (HDL) level, hypertension, and hyperglycemia where the incidence increases among the office workers. Uric acid is often associated with cardiovascular disease while risk factor of cardiovascular disease is associated with metabolic syndrome. Objective: To analyze the correlation between metabolic syndrome and serum uric acid level in office workers. Method: This study used medical record of health examination of PT Wijaya Karya Divisi IV male office workers aged of 20 – 60 years. The data taken consisted of abdominal circumference, triglyceride level, HDL level, fasting blood glucose level, blood pressure, and serum uric acid levels. The diagnostic criterion of metabolic syndrome which was used in this study was National Cholesterol Education Program’s Adult Treatment Panel III (NCEP ATP III) that had been modified for Asian. The correlation of metabolic syndrome and serum uric acid level was analyzed by chi-square test with IBM SPSS Statistic 20 application. Results: There was no significant correlation between metabolic syndrome and serum uric acid leves in male office workers of PT Wijaya Karya Divisi IV (p=0.598). Conclusion: Among the male office workers of PT Wijaya Karya Division IV, it had no significant correlation between metabolic syndrome and serum uric acid level.

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Association Between Serum Uric Acid Level and Components of the Metabolic Syndrome

Journal of the Chinese Medical Association ◽

10.1016/s1726-4901(09)70320-x ◽

2006 ◽

Vol 69 (11) ◽

pp. 512-516 ◽

Cited By ~ 75

Author(s):

Shi-Dou Lin ◽

Dong-Hwa Tsai ◽

Shang-Ren Hsu

Keyword(s):

Metabolic Syndrome ◽

Uric Acid ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Serum Uric Acid Level ◽

The Metabolic Syndrome

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Uric acid levels are critical for non-alcoholic fatty liver disease

10.21203/rs.2.23270/v1 ◽

2020 ◽

Author(s):

Guanqun Chao ◽

Yue Zhu ◽

Lizheng Fang

Keyword(s):

Risk Factors ◽

Uric Acid ◽

Risk Factor ◽

Fatty Liver ◽

Serum Uric Acid ◽

Uric Acid Level ◽

Acid Level ◽

Serum Uric Acid Level ◽

Density Lipoprotein ◽

Diagnostic Threshold

Abstract Background: To clarify the risk factors associated with NAFLD and further clarify the correlation between uric acid level and NAFLD by analyzing the correlation between NAFLD and different metabolic factors.Methods: Datas were obtained from subjects who underwent health examination in the Health promotion centre of Sir Run Run Shaw hospital of Zhejiang University from January 2016 to December 2017.The diagnosis of NAFLD was according to the clinical diagnosis of the Guidelines.Statistical analyses were performed using R software.Results: 79492 subjects were analyzed. 56680(71.3%) participants did not have NAFLD, 22812(28.7%) participants had NAFLD. Male, age, BMI, high blood pressure, central obesity, high glycosylated hemoglobin, high serum uric acid, high triglyceride, high total cholesterol, high low density lipoprotein cholesterol (LDL-C), abnormal liver function were risk factors of NAFLD, however, low high-density lipoprotein cholesterol (HDL-C) level was another risk factor of NAFLD.OR value suggested serum uric acid was a robust risk factor for NAFLD in all subgroups.In male group, AUC was 0.656 (95%CI: 0.651-0.661), the optimal diagnostic threshold was 395.5 mol/L, the sensitivity was 61.9%, the specificity was 61.1%, and the yoden index was 0.23. In female group, AUC was 0.716 (95%CI: 0.708-0.724), the optimal diagnostic threshold was 294.5 mol/L, sensitivity was 67.7%, specificity was 64.5%, and the Jordan index was 0.32.Conclusions: Our study suggested that there was a close correlation between serum uric acid level and NAFLD.Uric acid levels was a key risk factor for NAFLD.The diagnosis of fatty liver in patients can be preliminarily determined by detecting uric acid level.Contributions to the literature：1. The purpose of this study was to clarify the risk factors associated with NAFLD and further clarify the correlation between uric acid level and NAFLD by analyzing the correlation between NAFLD and different metabolic factors in the physical examination population.2. There was a close correlation between serum uric acid level and NAFLD.Uric acid levels was a key risk factor for NAFLD.3. The diagnosis of fatty liver in patients can be preliminarily determined by detecting uric acid level.

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