Coetzee’s interest in destabilizing the boundaries of literature and philosophy is most evident in later fictions such as Elizabeth Costello. But as Andrew Dean argues in this chapter, this interest in moving across boundaries in fact originates much earlier, in Coetzee’s quarrel with the institutions and procedures of literary criticism. Coetzee used the occasion of his inaugural professorial lecture at the University of Cape Town (Truth and Autobiography) to criticize the assumption that literary criticism can reveal truths about literature to which literary texts are themselves blind. Influenced in part by such figures as Jacques Derrida and Paul de Man, Coetzee posed a series of challenging questions about the desires at stake in the enterprise of literary criticism. Developing these thoughts, Dean explores the way in which Coetzee’s earlier fiction, including such texts as Foe (1986), is energized by its quarrelsome relationship with literary criticism and theory, especially postcolonial theory.