Laser Fabrication of Jagged-Shaped Stainless Steel Microneedle Imitating Mosquito’s Maxilla

2016 ◽  
Vol 10 (6) ◽  
pp. 958-964 ◽  
Author(s):  
Yasuhiro Hara ◽  
◽  
Masahiro Yamada ◽  
Chikako Tatsukawa ◽  
Tomokazu Takahashi ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Femtosecond Laser ◽  
Machine Tool ◽  
Blood Sugar Level ◽  
Three Dimensional ◽  
Laser Machining ◽  
Laser Fabrication ◽  
Medical Practices ◽  
Stainless Steel Foil ◽  
Electrolytic Etching

The demand for the development of low-invasive injection needles or needle-shaped tools for applications in medical practices, such as blood sampling and blood sugar level tests, are growing. We observed a mosquito’s penetration motions and fabricated low-invasive microneedles from 30-μm-thick stainless steel foil, imitating a pair of the mosquito’s maxillae. In our earlier studies, we attempted to fabricate needle tips with jagged portions by using a specially ordered machine tool and sharpening them by electrolytic etching, but found it difficult to maintain the needle tips in a jagged shape. However, in this study we successfully fabricated microneedles (70μm in width and 2.2 mm in length) with three-dimensionally sharpened tips (angled at 15° on the upper surface and sides) by machining 30-μm-thick stainless steel foil by femtosecond laser. Femtosecond laser machining can be applied to any type of material and can fabricate any desired three-dimensional structures by changing the angles at which the materials are set.

scholarly journals Three-dimensional femtosecond laser fabrication of waveguide beam splitters in LiNbO_3 crystal

2015 ◽  
Vol 5 (6) ◽  
pp. 1274 ◽  
Author(s):  
Jinman Lv ◽  
Yazhou Cheng ◽  
Weihao Yuan ◽  
Xiaotao Hao ◽  
Feng Chen
Keyword(s):  
Femtosecond Laser ◽  
Three Dimensional ◽  
Laser Fabrication ◽  
Beam Splitters

scholarly journals Drilling of Micron Size Holes in Stainless Steel Foil by using Femtosecond Laser Trepanned Method

2017 ◽  
Vol 19 (2) ◽  
pp. 209-215 ◽  
Author(s):  
kang min gi ◽  
이호 ◽  
이종훈 ◽  
Hyun Deok Kim ◽  
안윤준 ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Femtosecond Laser ◽  
Stainless Steel Foil ◽  
Micron Size

scholarly journals Fabrication of Microneedle from Stretched Biodegradable Polymer Sheet by 3D Laser Machining

2020 ◽  
Vol 32 (2) ◽  
pp. 390-400
Author(s):  
Seiji Aoyagi ◽  
Junya Sato ◽  
Tomokazu Takahashi ◽  
Masato Suzuki ◽  
Shinichi Matsumoto ◽  
...  
Keyword(s):  
Injection Molding ◽  
Femtosecond Laser ◽  
Polylactic Acid ◽  
Biodegradable Polymer ◽  
Test Piece ◽  
Three Dimensional ◽  
Artificial Skin ◽  
Laser Machining ◽  
Resistance Force ◽  
Fabrication Method

Polylactic acid (PLA) microneedles have been usually fabricated by injection molding. Herein, we consider microneedles that mimic the maxillae of mosquito proboscises, which have sharp tips with jagged harpoon-like protrusions. In case of such microneedles, filling the melting PLA resin up to the tip of the mold trough without burrs is challenging. To address this issue, we have proposed a new microneedle fabrication method in this paper. In this method, the needle with the desired shape was obtained from a PLA sheet by femtosecond laser machining. The needle was turned by 90°, and its tip further cut obliquely with the laser for three-dimensional (3D) sharpening. Tensile and buckling tests were conducted by using a test piece cut out from the PLA sheet. It was experimentally established that the strength and Young’s modulus along the sheet’s stretch direction are higher than those along its perpendicular direction. The 3D sharpened PLA microneedle successfully penetrated an artificial skin made of polydimethylsiloxane. A pair of microneedles were alternately vibrated against each other, mimicking the motion of mosquito two maxillae. With this alternate vibration, the resistance force during insertion was found to be lower compared to that without vibration.

Femtosecond laser processing stainless steel foil and its Fourier spectrum detection

2020 ◽  
Vol 16 (6) ◽  
pp. 471-476
Author(s):  
Dong-ming Tu ◽  
Hao-yue Ma ◽  
Xiao-rui Jiang ◽  
Hong-liang Liu ◽  
Peng-fei Wu ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Femtosecond Laser ◽  
Laser Processing ◽  
Fourier Spectrum ◽  
Stainless Steel Foil ◽  
Spectrum Detection ◽  
Femtosecond Laser Processing

Direct laser fabrication of three dimensional components using SC420 stainless steel

2013 ◽  
Vol 47 ◽  
pp. 731-736 ◽  
Author(s):  
G.A. Ravi ◽  
X.J. Hao ◽  
N. Wain ◽  
X. Wu ◽  
M.M. Attallah
Keyword(s):  
Stainless Steel ◽  
Three Dimensional ◽  
Laser Fabrication ◽  
Direct Laser ◽  
Direct Laser Fabrication

scholarly journals A Numerical Study of Slip System Evolution in Ultra-Thin Stainless Steel Foil

Materials ◽  
2019 ◽  
Vol 12 (11) ◽  
pp. 1819 ◽  
Author(s):  
Zhongkai Ren ◽  
Wanwan Fan ◽  
Jie Hou ◽  
Tao Wang
Keyword(s):  
Stainless Steel ◽  
Slip System ◽  
Numerical Study ◽  
Three Dimensional ◽  
304 Stainless Steel ◽  
Slip Systems ◽  
Deformation Degree ◽  
Engineering Strain ◽  
Stainless Steel Foil ◽  
Grain Orientations

In order to quantitatively describe the effect of the initial grain orientation on the inhomogeneous deformation of 304 austenitic stainless steel foil during tension, a three-dimensional uniaxial tension model was established, based on the crystal plasticity finite element method (CPFEM) and Voronoi polyhedron theory. A three-dimensional representative volume element (RVE) was used to simulate the slip deformation of 304 stainless steel foil with five typical grain orientations under the same engineering strain. The simulation results show that the number and characteristics of active slip systems and the deformation degree of the grain are different due to the different initial grain orientations. The slip systems preferentially initiate at grain boundaries and cause slip system activity at the interior and free surface of the grain. The Brass, S, and Copper oriented 304 stainless steel foil exhibits a high strain hardening index, which is beneficial to strengthening. However, the Cube and Goss oriented 304 stainless steel foil has a low deformation resistance and is prone to plastic deformation.

Three-Dimensional Femtosecond Laser Fabrication

2019 ◽  
Vol 16 (41) ◽  
pp. 57-63 ◽  
Author(s):  
S. Juodkazis ◽  
V. Mizeikis ◽  
Y. Nishijima ◽  
W. Ebina ◽  
H. Misawa ◽  
...  
Keyword(s):  
Femtosecond Laser ◽  
Three Dimensional ◽  
Laser Fabrication
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