scholarly journals Inhibition of protein kinase C alpha attenuates lipopolysaccharide-triggered acute lung injury by alleviating the hyperinflammatory response and oxidative stress

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Yang Chen ◽  
Pengcheng Lin ◽  
Wengang Nan ◽  
Shanshan Su ◽  
Hong Zheng ◽  
...  
2020 ◽  
Vol 98 (4) ◽  
pp. 243-251
Author(s):  
Mutlu Sarikaya ◽  
Nuray Yazihan ◽  
Net Daş Evcimen

Protein kinase C (PKC) and aldose reductase (AR) enzyme activities are increased in diabetes and complications are include retinopathy, nephropathy, and neuropathy. However, the relationship between PKC and AR and the underlying molecular mechanisms is still unclear. We aimed to evaluate the relationship between these two enzymes and clarify the underlying molecular mechanisms by the related signaling molecules. The effects of hyperglycemia and oxidative stress on AR and PKC enzymes and the signaling molecules such as nuclear factor-kappa B (NF-κB), inhibitor kappa B-alpha (IkB-α), total c-Jun, phospho c-Jun, and stress-activated protein kinases (SAPK)/Jun amino-terminal kinases (JNK) were evaluated in human retinal pigment epithelial cells (ARPE-19). AR, PKC protein levels, and related signaling molecules increased with hyperglycemia and oxidative stress. The AR inhibitor sorbinil decreased PKC expression and activity and all signaling molecule protein levels. Increased AR expression during hyperglycemia and oxidative stress was found to be correlated with the increase in PKC expression and activity in both conditions. Decreased expression and activity of PKC and the protein levels of related signaling molecules with the AR inhibitor sorbinil showed that AR enzyme may play a key role in the expression of PKC enzyme and oxidative stress during diabetes.


1997 ◽  
Vol 44 (2) ◽  
pp. 349
Author(s):  
Yong Hoon Kim ◽  
Seung Hyug Moon ◽  
Hyeon Tae Kim ◽  
Sin Young Kee ◽  
Jae Hak Ju ◽  
...  

2000 ◽  
Vol 28 (9) ◽  
pp. 1349-1361 ◽  
Author(s):  
Rayudu Gopalakrishna ◽  
Susan Jaken

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Asieh Hosseini ◽  
Mohammad Abdollahi

Diabetic neuropathy (DN) is a widespread disabling disorder comprising peripheral nerves' damage. DN develops on a background of hyperglycemia and an entangled metabolic imbalance, mainly oxidative stress. The majority of related pathways like polyol, advanced glycation end products, poly-ADP-ribose polymerase, hexosamine, and protein kinase c all originated from initial oxidative stress. To date, no absolute cure for DN has been defined; although some drugs are conventionally used, much more can be found if all pathophysiological links with oxidative stress would be taken into account. In this paper, although current therapies for DN have been reviewed, we have mainly focused on the links between DN and oxidative stress and therapies on the horizon, such as inhibitors of protein kinase C, aldose reductase, and advanced glycation. With reference to oxidative stress and the related pathways, the following new drugs are under study such as taurine, acetyl-L-carnitine, alpha lipoic acid, protein kinase C inhibitor (ruboxistaurin), aldose reductase inhibitors (fidarestat, epalrestat, ranirestat), advanced glycation end product inhibitors (benfotiamine, aspirin, aminoguanidine), the hexosamine pathway inhibitor (benfotiamine), inhibitor of poly ADP-ribose polymerase (nicotinamide), and angiotensin-converting enzyme inhibitor (trandolapril). The development of modern drugs to treat DN is a real challenge and needs intensive long-term comparative trials.


2012 ◽  
Vol 9 (1) ◽  
pp. 47-57 ◽  
Author(s):  
Amanda Valnier Steckert ◽  
Samira Silva Valvassori ◽  
Francielle Mina ◽  
Jessica Lopes-Borges ◽  
Roger Bitencourt Varela ◽  
...  

2007 ◽  
Vol 101 (6) ◽  
pp. 1205-1211 ◽  
Author(s):  
Stefan Hammerschmidt ◽  
Tobias Vogel ◽  
Susan Jockel ◽  
Christian Gessner ◽  
Hans-Jürgen Seyfarth ◽  
...  

2015 ◽  
Vol 15 (4) ◽  
pp. 206 ◽  
Author(s):  
Jong J. Ahn ◽  
Jong P. Jung ◽  
Soon E. Park ◽  
Minhyun Lee ◽  
Byungsuk Kwon ◽  
...  

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