scholarly journals Post-traumatic osteoarthritis (PTOA) animal model to understand pathophysiology of osteoarthritis

2019 ◽  
Vol 7 (S3) ◽  
pp. S81-S81
Author(s):  
Quante Singleton ◽  
Santul Bapat ◽  
Sadanand Fulzele
Keyword(s):  
Animal Model ◽  
Post Traumatic

S.21.03 Developing an animal model for post-traumatic stress disorder

2003 ◽  
Vol 13 ◽  
pp. S152-S153 ◽  
Author(s):  
G. Yadid ◽  
I. Gispan-Herman ◽  
Y. Kesner ◽  
Y. Weizman ◽  
A. Mendelman ◽  
...  
Keyword(s):  
Animal Model ◽  
Post Traumatic Stress Disorder ◽  
Traumatic Stress ◽  
Stress Disorder ◽  
Post Traumatic Stress ◽  
Post Traumatic

Translational Research from Animals to Humans

2016 ◽  
Author(s):  
Shigeru Morinobu ◽  
Shigeto Yamamoto ◽  
Manabu Fuchikami
Keyword(s):  
Animal Model ◽  
Fear Conditioning ◽  
Fear Extinction ◽  
Contextual Fear Conditioning ◽  
Behavioral Characteristics ◽  
Post Traumatic Stress ◽  
Contextual Fear ◽  
Glycine Transporter 1 ◽  
Post Traumatic ◽  
Prolonged Stress

To elucidate the pathophysiology of post-traumatic stress disorder (PTSD), the establishment of an appropriate animal model is necessary. In a series of studies, the authors validated single prolonged stress (SPS) as a model for PTSD. SPS-treated rats mimic the pathophysiological abnormalities and behavioral characteristics of PTSD, such as enhanced anxiety-like behavior, glucocorticoid negative feedback, and analgesia. In addition, the authors demonstrated enhanced freezing in response to contextual fear conditioning, and impaired extinction of fear memory, which was alleviated by D-cycloserine (DCS). In parallel, there was a decrease in extracellular glycine mediated by an increase in glycine transporter 1 in the hippocampus of SPS-treated rats after fear conditioning, which suggested that activation of N-methyl-D-asparate receptor by DCS during fear extinction training might alleviate the impaired fear extinction. This chapter summarizes PTSD-like symptoms in SPS and evaluates the validity of SPS as an animal model of PTSD.

Automated Bone Segmentation and Surface Evaluation of a Small Animal Model of Post-Traumatic Osteoarthritis

2017 ◽  
Vol 45 (5) ◽  
pp. 1227-1235 ◽  
Author(s):  
Austin J. Ramme ◽  
Kevin Voss ◽  
Jurinus Lesporis ◽  
Matin S. Lendhey ◽  
Thomas R. Coughlin ◽  
...  
Keyword(s):  
Animal Model ◽  
Small Animal ◽  
Bone Segmentation ◽  
Small Animal Model ◽  
Post Traumatic

scholarly journals Non-terminal animal model of post-traumatic osteoarthritis induced by acute joint injury

2013 ◽  
Vol 21 (5) ◽  
pp. 746-755 ◽  
Author(s):  
M.K. Boyce ◽  
T.N. Trumble ◽  
C.S. Carlson ◽  
D.M. Groschen ◽  
K.A. Merritt ◽  
...  
Keyword(s):  
Animal Model ◽  
Joint Injury ◽  
Post Traumatic
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