scholarly journals Extracapsular lymph node involvement in patients with esophageal cancer treated with neoadjuvant chemoradiation therapy followed by surgery: the closer you look, the less you see

2017 ◽  
Vol 9 (11) ◽  
pp. 4270-4272
Author(s):  
Yin-Kai Chao
Keyword(s):  
Esophageal Cancer ◽  
Lymph Node ◽  
Lymph Node Involvement ◽  
Neoadjuvant Chemoradiation ◽  
Chemoradiation Therapy ◽  
Neoadjuvant Chemoradiation Therapy ◽  
Node Involvement

Impact of Extracapsular Lymph Node Involvement After Neoadjuvant Chemoradiation Therapy Followed by Surgery in Carcinoma of the Esophagus

2018 ◽  
Vol 268 (6) ◽  
pp. 1000-1007 ◽  
Author(s):  
Lieven P. Depypere ◽  
Johnny Moons ◽  
Christophe Mariette ◽  
Xavier B. D’Journo ◽  
Pascal A. Thomas ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Involvement ◽  
Neoadjuvant Chemoradiation ◽  
Chemoradiation Therapy ◽  
Carcinoma Of The Esophagus ◽  
Neoadjuvant Chemoradiation Therapy ◽  
Node Involvement

scholarly journals RA09.02: LYMPH NODE RESPONSE AFTER NEOADJUVANT CHEMORADIATION THERAPY FOR ESOPHAGEAL ADENOCARCINOMA: TIME FOR AN APPROPRIATE YPN CLASSIFICATION

2018 ◽  
Vol 31 (Supplement_1) ◽  
pp. 40-40
Author(s):  
Lieven Depypere ◽  
Gert De Hertogh ◽  
Johnny Moons ◽  
An-Lies Provoost ◽  
Toni Lerut ◽  
...  
Keyword(s):  
Overall Survival ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Esophageal Adenocarcinoma ◽  
Primary Tumor ◽  
Median Overall Survival ◽  
Lymph Node Involvement ◽  
Neoadjuvant Chemoradiation ◽  
Chemoradiation Therapy ◽  
Node Involvement

Abstract Background Response of the primary tumor and lymph node involvement are the most important prognosticators in resected patients with esophageal adenocarcinoma after neoadjuvant chemoradiation. Response on the primary tumor is well established using T(umor) R(egression) G(rading). However, little is known about the prognostic value of lymph node response in these patients. Methods Hematoxylin-eosin slides of 193 adenocarcinoma patients with clinical suspicion of lymph node involvement (cN+) and treated with neoadjuvant chemoradiation therapy between 2008 and 2015 were all reassessed by a senior pathologist. Lymph node response (LNR) was defined as a combination of central fibrosis and at least one other characteristic such as hemosiderin pigment, acellular mucin pools, foam cells, giant cells or calcifications. Lymph nodes were categorized in four categories: 1° as positive (ypN+) when viable tumor was found according to TNM 8th edition. 2° as negative (ypN0) in absence of any viable tumor. 3° as lymph nodes with signs of LNR (LNR+). 4° as lymph nodes without signs of LNR (LNR-). All patients were grouped according to lymph node positivity and lymph node regression. Multivariate and survival analysis were performed by Cox proportional hazard regression analysis. Results Thirty-four patients were ypN + /LNR + , 60 were ypN + /LNR-, 41 were ypN0/LNR + and 58 were ypN0/LNR-. Median overall survival was respectively 41.0 months, 18.5 months, 31.2 months and 62.9 months. Survival was significantly different between ypN0 groups (P = 0.045) but not between ypN + groups (P = 0.299). Multivariate analysis showed that LNR was an independent prognosticator (P = 0.011). Conclusion In cN + esophageal adenocarcinoma patients treated with neoadjuvant chemoradiation with final pathology being ypN0 after esophagectomy, median overall survival is doubled when no signs of LNR were found suggesting these patients were in fact true N0 and that ypN0/LNR + have a similar prognosis as ypN + /LNR + . Using these four categories of ypN allows for more precise evaluation of the impact of induction therapy. Disclosure All authors have declared no conflicts of interest.

Prognostic Significance of Tumor Stage and Lymph Node Involvement in Thoracic Esophageal Cancer

1988 ◽  
pp. 709-713 ◽  
Author(s):  
P. Sorrentino ◽  
A. Ruol ◽  
C. Castoro ◽  
M. Ferrini ◽  
A. Piccoli ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Lymph Node ◽  
Prognostic Significance ◽  
Tumor Stage ◽  
Lymph Node Involvement ◽  
Thoracic Esophageal Cancer ◽  
Node Involvement

A Clinical Nomogram Predicting Pathologic Lymph Node Involvement in Esophageal Cancer Patients

2010 ◽  
Vol 128 ◽  
pp. 215-222 ◽  
Author(s):  
Puja Gaur ◽  
Boris Sepesi ◽  
Wayne L. Hofstetter ◽  
Arlene M. Correa ◽  
Manoop S. Bhutani ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Lymph Node Involvement ◽  
Node Involvement ◽  
Pathologic Lymph Node
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