Comparative Quantitative Lymph Node Assessment in Localized Esophageal Cancer Patients After R0 Resection With and Without Neoadjuvant Chemoradiation Therapy

2017 ◽  
Vol 21 (9) ◽  
pp. 1377-1384 ◽  
Author(s):  
Danica N. Giugliano ◽  
Adam C. Berger ◽  
Michael J. Pucci ◽  
Ernest L. Rosato ◽  
Nathaniel R. Evans ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Neoadjuvant Chemoradiation ◽  
Chemoradiation Therapy ◽  
R0 Resection ◽  
Neoadjuvant Chemoradiation Therapy ◽  
Lymph Node Assessment

scholarly journals p53 Gene Mutation Predicts Lymph Node Disease Following Neoadjuvant Chemoradiation Therapy in Rectal Cancer Patients

2011 ◽  
Vol 140 (5) ◽  
pp. S-1000
Author(s):  
Marjun Philip N. Duldulao ◽  
Zhenbin Chen ◽  
Wenyan Li ◽  
Wendy Lee ◽  
Joseph Kim ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Cancer Patients ◽  
Gene Mutation ◽  
P53 Gene ◽  
Neoadjuvant Chemoradiation ◽  
Chemoradiation Therapy ◽  
P53 Gene Mutation ◽  
Neoadjuvant Chemoradiation Therapy ◽  
Node Disease

Impact of total lymph node count on staging and survival after neoadjuvant chemoradiation therapy for rectal cancer.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 736-736
Author(s):  
Matthew David Hall ◽  
Timothy E. Schultheiss ◽  
Jeffrey Y.C. Wong ◽  
Yi-Jen Chen
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Neoadjuvant Chemoradiation ◽  
Chemoradiation Therapy ◽  
Neoadjuvant Chemoradiation Therapy ◽  
Significant Difference ◽  
The Impact ◽  
Positive Lymph Nodes

736 Background: Neoadjuvant chemoradiation therapy (CRT) results in fewer retrieved lymph nodes at the time of surgery for rectal cancer. The extent of optimal regional nodal dissection is based on guidelines developed before neoadjuvant CRT was commonly used. The purpose of this study is to assess the impact of the number of dissected and positive lymph nodes on overall survival (OS) for rectal cancer patients treated with neoadjuvant CRT. Methods: Treatment data were obtained by structured query on all patients with rectal adenocarcinoma (2000-2013) in the National Oncology Data Alliance, a proprietary database of merged tumor registries. Eligible patients were treated with neoadjuvant CRT followed by surgery and had complete data on the number of positive and dissected lymph nodes and dates of treatment. The relationships between number of lymph nodes examined and OS were separately analyzed in patients with 0, exactly 1, or any number of positive nodes. Results: The median number of lymph nodes examined was 11 (interquartile range 6-16). In 4,581 evaluable patients, there was a significant improvement in OS with the examination of more lymph nodes. Number of positive lymph nodes, number of lymph nodes dissected, age, gender, grade, marital status, and race were significant predictors of OS on multivariate analysis. On subset analysis, patients with 0, exactly 1, and any number of positive nodes were found to have better OS with increasing number of lymph nodes dissected up to eight. Increasing overall mortality was observed in patients with 0, 1, 2-4, 5-7, and ≥8 positive lymph nodes. The Kaplan-Meier curves showed a clear statistically significant difference in OS in patients divided into these five nodal groupings (p<0.0001). Conclusions: Patients with eight or more lymph nodes examined had the greatest improvement in OS in rectal cancer patients treated with neoadjuvant CRT. This should be considered the threshold for an adequate lymph node sampling in this population. A five-tier nodal grouping was found to best forecast prognosis based on the number of positive lymph nodes identified.

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