scholarly journals SWOG study shows significant long-term overall survival for advanced gastrointestinal stromal tumor patients with imatinib treatment

2018 ◽  
Vol 3 ◽  
pp. 10-10
Author(s):  
Marcel Trautmann ◽  
Sebastian Huss ◽  
Wolfgang Hartmann ◽  
Eva Wardelmann
Keyword(s):  
Overall Survival ◽  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Imatinib Treatment ◽  
Tumor Patients

Gastrointestinal stromal tumor – A review of clinical studies

2019 ◽  
Vol 25 (6) ◽  
pp. 1473-1485 ◽  
Author(s):  
Ardavan Khoshnood
Keyword(s):  
Overall Survival ◽  
Clinical Trials ◽  
Gastrointestinal Stromal Tumor ◽  
Survival Rates ◽  
Stromal Tumor ◽  
Tumor Patients ◽  
Third Line ◽  
New Treatments ◽  
Common Mesenchymal Tumor ◽  
Overall Survival Rates

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. With the advent of Imatinib, the treatment of gastrointestinal stromal tumor has been revolutionized as both the progression-free and overall survival rates have increased dramatically. Unfortunately, gastrointestinal stromal tumor patients on Imatinib do eventually fail due to resistance. Even though sunitinib and regorafenib have been shown to be highly effective as second- and third-line treatments, both have limited effects. New treatments are highly warranted for this reason. In this present review, 25 registered pharmacological clinical trials at ClinicalTrials.gov have been reviewed and show promising and encouraging results.

Critical Update and Emerging Trends in Imatinib Treatment for Gastrointestinal Stromal Tumor

2007 ◽  
Vol 2 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Ugo De Giorgi ◽  
Alberto Pupi ◽  
Gina Turrisi ◽  
Iolanda Montenora ◽  
Stefano Morini ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Imatinib Treatment ◽  
Emerging Trends

Multiple Bowel Perforations Complicating Imatinib Treatment for Advanced Gastrointestinal Stromal Tumor

2008 ◽  
Vol 206 (2) ◽  
pp. 386-387 ◽  
Author(s):  
Massimo Chiarugi ◽  
Christian Galatioto ◽  
Piero V. Lippolis ◽  
Massimo Seccia
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Imatinib Treatment

Meta-analysis for the Association between Overall Survival and Progression-Free Survival in Gastrointestinal Stromal Tumor

2014 ◽  
Vol 21 (2) ◽  
pp. 295-302 ◽  
Author(s):  
Ipek Özer-Stillman ◽  
Lauren Strand ◽  
Jane Chang ◽  
Ateesha F. Mohamed ◽  
Katherine E. Tranbarger-Freier
Keyword(s):  
Overall Survival ◽  
Gastrointestinal Stromal Tumor ◽  
Meta Analysis ◽  
Progression Free Survival ◽  
Stromal Tumor ◽  
Free Survival

scholarly journals Successful Perioperative and Surgical Treatment of a Rare Case of Extra-Gastrointestinal Stromal Tumor Arising in the Prostate Gland

2019 ◽  
Vol 12 (1) ◽  
pp. 183-191 ◽  
Author(s):  
Patrick Schöffski ◽  
Raf Sciot ◽  
Maria Debiec-Rychter ◽  
Johan Van Ongeval ◽  
André D'Hoore ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Prostate Gland ◽  
Interstitial Cells ◽  
Stromal Tumor ◽  
Imatinib Treatment ◽  
Smooth Muscle Contractility ◽  
Double Mutation ◽  
Primary Gist ◽  
Common Precursor ◽  
Cells Of Cajal

We report a very uncommon case of a primary, non-metastatic gastrointestinal stromal tumor (GIST) arising in the prostate gland in a 60-year-old patient. The morphology and immunohistochemical profile of the disease resembled GIST of gastrointestinal origin, and the molecular driver of this malignancy was a double mutation in exons 11 and 13 of the KIT gene. The tumor was proliferating slowly, did respond to neoadjuvant therapy with the KIT-inhibiting agent imatinib and was cured by radical, retro-pubic prostatectomy followed by adjuvant imatinib treatment. We postulate that primary GIST tumors of the prostate can arise from prostatic interstitial cells, which are the pacemakers of smooth muscle contractility in the gland, and possibly share a common precursor with typical GIST and the interstitial cells of Cajal in the gastrointestinal tract.

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