Selective stabilization and elimination of climbing fiber- Purkinje cell synapse in the developing cerebellum: Signal transduction and critical period.

2002 ◽  
Vol 19 (12) ◽  
pp. 1404-1405
Author(s):  
S KAKIZAWA
Keyword(s):  
Signal Transduction ◽  
Purkinje Cell ◽  
Critical Period ◽  
Climbing Fiber ◽  
Selective Stabilization ◽  
Developing Cerebellum ◽  
Cell Synapse

P/Q type voltage dependent Ca2+ channel is crucial for early postnatal development of climbing fiber to Purkinje cell synapse

2010 ◽  
Vol 68 ◽  
pp. e37-e38
Author(s):  
Kouichi Hashimoto ◽  
Mika Tsujita ◽  
Kazuo Kitamura ◽  
Taisuke Miyazaki ◽  
Maya Yamazaki ◽  
...  
Keyword(s):  
Purkinje Cell ◽  
Postnatal Development ◽  
Climbing Fiber ◽  
Early Postnatal Development ◽  
Voltage Dependent ◽  
Cell Synapse

Metabotropic Glutamate Receptor-Mediated Currents at the Climbing Fiber to Purkinje Cell Synapse

2005 ◽  
Vol 45 (6) ◽  
pp. 1536-1538
Author(s):  
Pavle R. Andjus ◽  
Aleksandar Bajić ◽  
Lan Zhu ◽  
Piergiorgio Strata
Keyword(s):  
Purkinje Cell ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Climbing Fiber ◽  
Metabotropic Glutamate ◽  
Cell Synapse

scholarly journals The rich get richer: synaptic remodeling between climbing fibers and Purkinje cells in the developing cerebellum begins with positive feedback addition of synapses

2019 ◽  
Author(s):  
Alyssa Michelle Wilson ◽  
Richard Schalek ◽  
Adi Suissa-Peleg ◽  
Thouis Ray Jones ◽  
Seymour Knowles-Barley ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Purkinje Cell ◽  
Postnatal Development ◽  
Purkinje Cells ◽  
Positive Feedback ◽  
Climbing Fiber ◽  
Climbing Fibers ◽  
List Type ◽  
Developing Cerebellum ◽  
Serial Electron Microscopy

SUMMARYDuring postnatal development, cerebellar climbing fibers strongly innervate a subset of their original Purkinje cell targets and eliminate their connections from the rest. In the adult, each climbing fiber innervates a small number of Purkinje cells and each Purkinje cell is innervated by a single climbing fiber. To get insight about the processes responsible for this remapping, we reconstructed serial electron microscopy datasets from mice during the first postnatal week. In contrast to adult connectivity, individual neonatal climbing fibers innervate many nearby Purkinje cells, and multiple climbing fibers innervate each Purkinje cell. Between postnatal days 3 and 7, Purkinje cells retract long dendrites and grow many proximal dendritic processes. On this changing landscape, individual climbing fibers selectively add many synapses to a subset of Purkinje cell targets in a positive-feedback manner, without pruning synapses from other Purkinje cells. The active zone sizes of synapses associated with powerful versus weak inputs are indistinguishable. These results show that changes in synapse number rather than synapse size are the predominant form of early developmental plasticity. Finally, although multiple climbing fibers innervate each Purkinje cell in early postnatal development, the number of climbing fibers and Purkinje cells in a local cerebellar region nearly match. Thus, initial over-innervation of Purkinje cells by climbing fibers is economical, in that the number of axons entering a region is enough to assure that each axon ends up with a postsynaptic target, and that none branched there in vain.HIGHLIGHTSDeveloping climbing fibers establish synapses on many neighboring Purkinje cells unlike the sparse pattern of innervation in later lifeClimbing fibers add many synapses onto a few of their Purkinje targets before the pruning stage in a rich-get-richer type processThe synapse sizes of strengthened and weakened climbing fiber inputs are indistinguishable.Exuberant branching of climbing fiber axons in early postnatal life appears to be economical because the numbers of axons and Purkinje cells in a local region match, ensuring that each axon can establish a long-lasting connection thereBLURBHigh-resolution serial electron microscopy reconstructions reveal that climbing fiber-Purkinje cell synaptic refinement in the developing cerebellum begins with significant synapse addition. Climbing fibers focus their synapses onto a smaller number of Purkinje cells by selectively adding synapses onto some target cells. All axons that project to a region in development play a role in the final connectivity.

scholarly journals Translocation of a “Winner” Climbing Fiber to the Purkinje Cell Dendrite and Subsequent Elimination of “Losers” from the Soma in Developing Cerebellum

Neuron ◽  
2009 ◽  
Vol 63 (1) ◽  
pp. 106-118 ◽  
Author(s):  
Kouichi Hashimoto ◽  
Ryoichi Ichikawa ◽  
Kazuo Kitamura ◽  
Masahiko Watanabe ◽  
Masanobu Kano
Keyword(s):  
Purkinje Cell ◽  
Climbing Fiber ◽  
Cell Dendrite ◽  
Purkinje Cell Dendrite ◽  
Subsequent Elimination ◽  
Developing Cerebellum

GABAergic inhibition onto Purkinje cell soma is crucial for climbing fiber synapse elimination in developing cerebellum

2009 ◽  
Vol 65 ◽  
pp. S52
Author(s):  
Hisako Nakayama ◽  
Taisuke Miyazaki ◽  
Kouichi Hashimoto ◽  
Yuchio Yanagawa ◽  
Kunihiko Obata ◽  
...  
Keyword(s):  
Purkinje Cell ◽  
Climbing Fiber ◽  
Gabaergic Inhibition ◽  
Synapse Elimination ◽  
Cell Soma ◽  
Developing Cerebellum

scholarly journals Introduction of synaptotagmin 7 promotes facilitation at the climbing fiber to Purkinje cell synapse

Cell Reports ◽  
2021 ◽  
Vol 36 (12) ◽  
pp. 109719
Author(s):  
Christopher Weyrer ◽  
Josef Turecek ◽  
Bailey Harrison ◽  
Wade G. Regehr
Keyword(s):  
Purkinje Cell ◽  
Climbing Fiber ◽  
Cell Synapse
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