Comparative Study of Granisetron and Ondansetron for the Prevention of Post Operative Nausea and Vomiting in Patients Undergoing Total Abdominal Hysterectomy Under General Anaesthesia

Background Post operative nausea and vomiting (PONV) is a common problem following general as well as regional anaesthesia. This causes great distress to the patient, may worsen surgical outcome and prolongs hospital stay. Prophylatic use of antiemetic in the preoperative or postoperative period reduces PONV. Objectives The study was designed to compare antiemetic effects of intravenous use of granisetron and ondansetron in the peroperative period for prevention of PONV following elective gynaecological surgery under general anaesthesia. Methods 60 (sixty) patients undergoing elective gynaecological surgery (total abdominal hysterectomy) under general anaesthesia of ASA grade I and II aged between 35-50 years were selected randomly and divided into two groups (group O & group G) of thirty patients each. Patients of group O received intravenous Inj, ondansetron 0.1 mg/kg body weight & group G received intravenous Inj. granisetron 2 mg bolus over 30 sec just before peritoneal closure. Both the group received a standard general anaesthesia. Postoperative analgesia was provided with diclofenac suppository (50mg) and ketorolac tromethamine 30mg intra-muscularly. In the recovery room occurrence of post operative nausea and vomiting was assessed for 12 hours. All data were compiled and analyzed for statistical significance by Students t tests (unpaired). P<0 .05 (CL 95%) was considered as significance. Results The incidence of post operative nausea and vomiting was reduced in both groups but no significant difference between the groups. No haemodynamic or psycho-mimetic adverse events were observed in the patients. DOI: http://dx.doi.org/10.3329/jbsa.v24i1.19795 Journal of Bangladesh Society of Anaesthesiologists 2011; 24(1): 18-22

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Semi-Permanent Acupuncture Needles in the Prevention of Post-Operative Nausea and Vomiting

Acupuncture in Medicine ◽

10.1136/aim.14.2.68 ◽

1996 ◽

Vol 14 (2) ◽

pp. 68-70 ◽

Cited By ~ 8

Author(s):

J Andrzejowski ◽

D Woodward

Keyword(s):

Controlled Trial ◽

Total Abdominal Hysterectomy ◽

Abdominal Hysterectomy ◽

Nausea And Vomiting ◽

Control Group ◽

Study Group ◽

Median Score ◽

Severe Nausea ◽

Post Operative Nausea ◽

Trial Study Group

The efficacy of acupressure and acupuncture at the Pericardium 6 (PC.6) point in relieving post-operative nausea and vomiting (PONV) is well known. Lengthy manual stimulation of the needles, or electrostimulation, is inconvenient and incurs extra costs. The aim of this study was to test the effectiveness of the antiemetic action of semi-permanent acupuncture needles (SPANs), a cheap and convenient method of administering acupuncture, in the first 48 hours following gynaecological surgery. Patients (n = 36) having total abdominal hysterectomy were studied in a randomised, placebo controlled trial. Study group patients had SPANs inserted in PC.6 on both wrists. The control group had SPANs inserted into sham points on their forearms. There was no difference in the median nausea scores between the groups; however six patients suffered moderate or severe nausea during the second 24 hours in the control group, with none in the study group (p < 0.05). In addition, the nausea score between 8 and 24 hours in patients who had previously experienced PONV, was lower in the study group (median score 2) compared to the control group (median score 4) (p < 0.05). We conclude that the use of SPANs does not reduce the overall incidence of nausea and vomiting but does appear to reduce the severity of nausea in the second 24 hours, and has a greater effect on patients who had had nausea and vomiting after a previous anaesthetic.

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