Influence of Wrist Tapping on Alpha Rhythm Synchronization in Patients with Juvenile Myoclonic Epilepsy

Background: The aim of this study was to assess the effect of wrist tapping (WT), according to the author's method, on the synchronization of alpha activity in healthy adults and patients with juvenile myoclonic epilepsy (JME). Methods and Results: The study included 71 people of working age, including 51 clinically healthy volunteers (median age - 39[21;56] years) and 20 patients with JME (median age 27[23;35] years). Under the influence of WT in a state of sensory deprivation, statistically significant changes in the alpha peak frequency (APF) (P<0.001) and alpha power (AP) (P<0.05) were found in healthy adults. In JME patients, there were statistically significant changes in the APF (P<0.05) and AP (P<0.05), as well as a statistically significant increase in the ARW (P<0.05) after WT. WT, according to the author's technique, allows reducing the severity of alpha rhythm synchronization and leads to a shift in the peak frequency of the alpha rhythm in the occipital leads towards the alpha-2 sub-frequency range and a decrease in AP in both healthy volunteers and JME patients. At the same time, the alpha range width in the occipital leads is statistically significantly increased in JME patients. Conclusion: The nature of the change in the alpha rhythm, in comparison with the control, indicates the phenomenon of resonance with the frequency of the WT rhythm. The WT effect testifies to the prospects of the clinical application of WT in JME, since it was previously shown that if the selected external frequencies enter into resonance with the neurons of the antiepileptic system, then an antiepileptic effect could be obtained.

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STUDY OFTHEINFLUENCE OF WRISTTAPPING ON ALPHA-RHYTHM SYNCHRONIZATION IN A

Archiv Euromedica ◽

10.35630/2199-885x/2020/10/4.28 ◽

2020 ◽

Vol 10 (4) ◽

pp. 118-123

Author(s):

Ekaterina Narodova ◽

Natalia Shnayder ◽

Vladislav Karnaukhov ◽

Kirill Petrov ◽

Valeriia Narodova

Keyword(s):

Healthy Volunteers ◽

Peak Power ◽

Alpha Rhythm ◽

Sensory Deprivation ◽

Peak Frequency ◽

Healthy Adults ◽

Clinical Use ◽

Working Age ◽

Hand Tapping ◽

Antiepileptic System

Objective: To study the effect of hand tapping on the synchronization of the alpha rhythm in healthy adults. Materials and Methods: The study included 51 clinically healthy volunteers of working age. Results: We have shown that under the influence of wrist tapping in a state of sensory deprivation in healthy adults there is a statistically significant change in the peak frequency (p = 0.0006) and peak power of the alpha rhythm (p = 0.0003), but the width of the peak plateau remains unchanged (p = 0.2). This effect of wrist tapping indicates the potential for clinical use in JME, since it was previously shown that if the selected external frequencies enter into resonance with the neurons of the antiepileptic system, then an antiepileptic effect can be obtained.

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Influence of wrist tapping on alpha rhythm synchronization in healthy adults and adults with juvenile myoclonic epilepsy

Journal of the Neurological Sciences ◽

10.1016/j.jns.2021.119183 ◽

2021 ◽

Vol 429 ◽

pp. 119183

Author(s):

Ekaterina Narodova ◽

Natalia Shnayder ◽

Vladislav Karnaukhov ◽

Elena Vayman

Keyword(s):

Alpha Rhythm ◽

Juvenile Myoclonic Epilepsy ◽

Healthy Adults ◽

Myoclonic Epilepsy

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Influence of anxiety on wrist tapping parameters and individual perception of one minute in healthy adults and in patients with juvenile myoclonic epilepsy

Russian Open Medical Journal ◽

10.15275/rusomj.2018.0415 ◽

2018 ◽

Vol 7 (4) ◽

pp. e0415

Author(s):

Ekaterina A. Narodova ◽

Natalia A. Shnayder ◽

Valeria V. Narodova ◽

Evgeny E. Erahtin ◽

Olga S. Shilkina ◽

...

Keyword(s):

Juvenile Myoclonic Epilepsy ◽

Healthy Adults ◽

Myoclonic Epilepsy ◽

Individual Perception

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Effect of Wrist Tapping on Interhemispheric Coherence in Patients with Juvenile Myoclonic Epilepsy

International Journal of Biomedicine ◽

10.21103/article11(1)_oa12 ◽

2021 ◽

Vol 11 (1) ◽

pp. 73-77

Author(s):

Ekaterina Narodova ◽

Natalia Shnayder ◽

Vladislav Karnaukhov ◽

Olesya Bogomolova ◽

Kirill Petrov ◽

...

Keyword(s):

Healthy Volunteers ◽

Epileptic Seizures ◽

Juvenile Myoclonic Epilepsy ◽

Myoclonic Epilepsy ◽

Control Group ◽

Alpha Band ◽

Epileptiform Discharges ◽

Interhemispheric Coherence ◽

Before And After ◽

The Brain

The aim of this study was to assess the dynamics of interhemispheric coherence (IC) as an indicator of integration of different areas of the brain and their participation in the performance of certain functions before and after wrist tapping (WT), using the author's method in juvenile myoclonic epilepsy (JME). Methods and Results: The study included 81 subjects of working age, including 51 clinically healthy volunteers (median age of 39[21;56] years) and 30 patients (median age of 27[23;38] years) with JME. Analysis of IC in the electrode pairs Fp1-Fp2, F3-F4, C3-C4, T3-T4 was performed using a computer encephalographic complex. A coherent EEG analysis was used to identify and evaluate the relationships between different areas of the brain. Based on the change in the coherence coefficients (CCs), the level of integrative activity of brain structures was quantified. In healthy volunteers, before and after WT, we observed a statistically significant decrease in CCs for the beta-1 band in the pairs Fp1-Fp2, F3-F4, and C3-C4 (P<0.05), while in the pair T3-T4, changes in CCs were not statistically significant (P>0.05). At the same time, a statistically significant decrease in CCs in the alpha band was found only in the frontal regions in the pairs Fp1-Fp2 and F3-F4 (P<0.05). No statistically significant changes were found in all the studied pairs in the theta band. When comparing CCs in JME patients in beta–1 and theta bands, before and after WT, we did not find statistically significant changes in CCs in all the studied electrode pairs. However, in the alpha band, we found a statistically significant decrease in CCs in the frontal region in the F3-F4 (P=0.0038) and C3-C4 electrode pairs (P=0.034). The results of the study of interhemispheric integration showed statistically significant differences between patients with JME and the control group. Conclusion: WT according to the author's method does not provoke the occurrence of interictal epileptiform discharges on the EEG and epileptic seizures in patients with JME. Coherent analysis showed positive changes in interhemispheric integrations of neurons in the beta–1 and alpha frequency ranges, mainly in the anterior hemispheres.

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