scholarly journals STUDY OFTHEINFLUENCE OF WRISTTAPPING ON ALPHA-RHYTHM SYNCHRONIZATION IN A

2020 ◽  
Vol 10 (4) ◽  
pp. 118-123
Author(s):  
Ekaterina Narodova ◽  
Natalia Shnayder ◽  
Vladislav Karnaukhov ◽  
Kirill Petrov ◽  
Valeriia Narodova
Keyword(s):  
Healthy Volunteers ◽  
Peak Power ◽  
Alpha Rhythm ◽  
Sensory Deprivation ◽  
Peak Frequency ◽  
Healthy Adults ◽  
Clinical Use ◽  
Working Age ◽  
Hand Tapping ◽  
Antiepileptic System

Objective: To study the effect of hand tapping on the synchronization of the alpha rhythm in healthy adults. Materials and Methods: The study included 51 clinically healthy volunteers of working age. Results: We have shown that under the influence of wrist tapping in a state of sensory deprivation in healthy adults there is a statistically significant change in the peak frequency (p = 0.0006) and peak power of the alpha rhythm (p = 0.0003), but the width of the peak plateau remains unchanged (p = 0.2). This effect of wrist tapping indicates the potential for clinical use in JME, since it was previously shown that if the selected external frequencies enter into resonance with the neurons of the antiepileptic system, then an antiepileptic effect can be obtained.

scholarly journals Influence of Wrist Tapping on Alpha Rhythm Synchronization in Patients with Juvenile Myoclonic Epilepsy

2020 ◽  
Vol 10 (4) ◽  
pp. 347-351
Author(s):  
Ekaterina Narodova ◽  
Natalia Shnayder ◽  
Vladislav Karnaukhov ◽  
Kirill Petrov ◽  
Valeriya Narodova
Keyword(s):  
Healthy Volunteers ◽  
Alpha Rhythm ◽  
Sensory Deprivation ◽  
Peak Frequency ◽  
Juvenile Myoclonic Epilepsy ◽  
Healthy Adults ◽  
Myoclonic Epilepsy ◽  
Alpha Power ◽  
Working Age ◽  
Antiepileptic System

Background: The aim of this study was to assess the effect of wrist tapping (WT), according to the author's method, on the synchronization of alpha activity in healthy adults and patients with juvenile myoclonic epilepsy (JME). Methods and Results: The study included 71 people of working age, including 51 clinically healthy volunteers (median age - 39[21;56] years) and 20 patients with JME (median age 27[23;35] years). Under the influence of WT in a state of sensory deprivation, statistically significant changes in the alpha peak frequency (APF) (P<0.001) and alpha power (AP) (P<0.05) were found in healthy adults. In JME patients, there were statistically significant changes in the APF (P<0.05) and AP (P<0.05), as well as a statistically significant increase in the ARW (P<0.05) after WT. WT, according to the author's technique, allows reducing the severity of alpha rhythm synchronization and leads to a shift in the peak frequency of the alpha rhythm in the occipital leads towards the alpha-2 sub-frequency range and a decrease in AP in both healthy volunteers and JME patients. At the same time, the alpha range width in the occipital leads is statistically significantly increased in JME patients. Conclusion: The nature of the change in the alpha rhythm, in comparison with the control, indicates the phenomenon of resonance with the frequency of the WT rhythm. The WT effect testifies to the prospects of the clinical application of WT in JME, since it was previously shown that if the selected external frequencies enter into resonance with the neurons of the antiepileptic system, then an antiepileptic effect could be obtained.

Study of the influence of anxiety on the parameters of hand tapping in patients with postoperative epilepsy in comparison with the group of healthy volunteers

2020 ◽  
pp. 49-56
Author(s):  
E. Narodova ◽  
N. Shnayder ◽  
A. Narodov ◽  
D. Dmitrenko
Keyword(s):  
Healthy Volunteers ◽  
Theoretical Basis ◽  
Focal Epilepsy ◽  
Disease Modifying Therapy ◽  
Hand Tapping ◽  
Disease Modifying

The presented work devoted to hand tapping is intended to lay foundations in a theoretical basis for the development of a new direction of non-drug disease-modifying therapy for structural focal epilepsy, implemented through the formation of a new dominant “healthy system” based on the distraction of the patient and switching of attention.

scholarly journals Effect of high nitrate vegetable juice supplementation on plasma nitrate and blood pressure in healthy adults: a pilot randomized crossover intervention in healthy volunteers

2021 ◽  
Author(s):  
Nour Elsahoryi ◽  
Christopher Cardwell ◽  
Sarah Gilchrist ◽  
Jayne Woodside
Keyword(s):  
Blood Pressure ◽  
Healthy Volunteers ◽  
Healthy Adults ◽  
Leafy Vegetable ◽  
Nitrate Content ◽  
Beetroot Juice ◽  
Green Leafy Vegetable ◽  
Vegetable Juice ◽  
Plasma Nitrate ◽  
Nitrate And Nitrite

Abstract Background: Beetroot juice has been demonstrated to decrease blood pressure due to the high inorganic nitrate content, but few studies have tested the effect of other high nitrate vegetable juices on blood pressure. Methods: This pilot randomized crossover trial aimed to investigate the effect of two different high nitrate vegetable juices on plasma nitrate concentrations and blood pressure in healthy adults. Eighteen healthy volunteers were randomized to receive 115 ml of beetroot juice or 250 ml of green leafy vegetable juice for seven days. Blood samples were collected, and clinic blood pressure measured at baseline and at the end of each juice consumption. Daily home blood pressure assessment was conducted two hours after juice consumption. Nitrate and nitrite concentrations were analysed using a commercially available kit on a Triturus automated ELISA analyser. Hills and Armitage analysis was used for the two- period crossover design and paired sample t- tests were performed to compare within-group changes. Results: Plasma nitrate and nitrite concentration significantly increased and there was significant reduction in clinic and home SBP mean during the beetroot juice period (P-values 0.004 and 0.002, respectively). Home DBP reduced significantly during green leafy vegetable juice consumption week (P-value 0.03). The difference between groups did not reach statistical significance during the formal crossover analysis adjusted for period effects. Conclusion: Beetroot juice and green leafy vegetable juice may reduce systolic or diastolic blood pressure but there was no statistically significant difference between the two juices, although this was only a pilot study.

scholarly journals Association between spectral characteristics of paraspinal muscles and functional disability in patients with low back pain: a cohort study

BMJ Open ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. e017091 ◽  
Author(s):  
Shin-Yi Chiou ◽  
Ermis Koutsos ◽  
Pantelis Georgiou ◽  
Paul H Strutton
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Peak Power ◽  
Functional Disability ◽  
Spectral Characteristics ◽  
Peak Torque ◽  
Healthy Adults ◽  
Erector Spinae ◽  
Emg Activity ◽  
Low Back

ObjectivesCharacteristics of muscle activity, represented by surface electromyography (EMG), have revealed differences between patients with low back pain (LBP) and healthy adults; how they relate to functional and clinical parameters remains unclear. The purpose of the current study was to examine the correlation between frequency characteristics of EMG (analysed using continuous wavelet transform (CWT) analysis) and patients’ self-rated score of disability.Design and settingThis is a case-control study with 15 patients with mechanical LBP without radicular symptoms. Patients were recruited from the orthopaedic clinic at Charing Cross Hospital. Ten healthy adults were recruited from the staff working in the hospital and associated university. Patients completed the Roland-Morris Disability Questionnaire (RMDQ) and bilateral EMG activity was obtained from erector spinae at vertebral levels L4 and T12. Subjects performed three brief maximal voluntary isometric contractions (MVICs) of the back extensors and the torque was measured using a dynamometer. CWT was applied to the EMG signals of each muscle in a 200 ms window centred around the peak torque obtained during the MVICs. The ratio (low/high frequencies) of the energy, the peak power and the frequency of the peak power were calculated for each recording site, averaged and correlated with the individual’s RMDQ score.ResultsPatients had lower peak power (T12 and L4) and lower frequency of the peak power (at T12) than the healthy adults. Additionally, RMDQ positively correlated to the average ratio of energy at T12 (r=0.63; p=0.012), that is, greater self-rated disability corresponded to a dominant distribution of energy in the lower frequencies.ConclusionThe current findings reveal alterations in EMG profile and its association with self-related back pain disability, suggesting that spectral characteristics of EMG reflect muscle function.

scholarly journals Shifts in broadband power and alpha peak frequency observed during long-term isolation

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Jan Weber ◽  
Timo Klein ◽  
Vera Abeln
Keyword(s):  
Sensory Deprivation ◽  
Peak Frequency ◽  
Neuronal Population ◽  
Confined Space ◽  
Eyes Closed ◽  
Eyes Open ◽  
Eeg Recordings ◽  
Induced Changes ◽  
Alpha Peak

Abstract Prolonged periods of social isolation and spatial confinement do not only represent an issue that needs to be faced by a few astronauts during space missions, but can affect all of us as recently shown during pandemic situations. The fundamental question, how the brain adapts to periods of sensory deprivation and re-adapts to normality, has only received little attention. Here, we use eyes closed and eyes open resting-state electroencephalographic (EEG) recordings to investigate how neural activity is altered during 120 days of isolation in a spatially confined, space-analogue environment. After disentangling oscillatory patterns from 1/f activity, we show that isolation leads to a reduction in broadband power and a flattening of the 1/f spectral slope. Beyond that, we observed a reduction in alpha peak frequency during isolation, but did not find strong evidence for isolation-induced changes that are of oscillatory nature. Critically, all effects reversed upon release from isolation. These findings suggest that isolation and concomitant sensory deprivation lead to an enhanced cortical deactivation which might be explained by a reduction in the mean neuronal population firing rate.

Experimental orofacial pain and sensory deprivation lead to perceptual distortion of the face in healthy volunteers

2015 ◽  
Vol 233 (9) ◽  
pp. 2597-2606 ◽  
Author(s):  
Lilja Kristín Dagsdóttir ◽  
Ina Skyt ◽  
Lene Vase ◽  
Lene Baad-Hansen ◽  
Eduardo Castrillon ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Orofacial Pain ◽  
Sensory Deprivation ◽  
Perceptual Distortion ◽  
The Face

scholarly journals Two Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Studies To Investigate the Safety, Tolerability, and Pharmacokinetics of an Anti-Influenza A Virus Monoclonal Antibody, MHAA4549A, in Healthy Volunteers

2016 ◽  
Vol 60 (9) ◽  
pp. 5437-5444 ◽  
Author(s):  
Jeremy J. Lim ◽  
Rong Deng ◽  
Michael A. Derby ◽  
Richard Larouche ◽  
Priscilla Horn ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Influenza A Virus ◽  
Influenza A ◽  
Phase 1 ◽  
Healthy Adults ◽  
Intravenous Dose ◽  
Fixed Dose ◽  
Single Intravenous Dose ◽  
Two Phase ◽  
Placebo Trial

ABSTRACTHospitalized patients with severe influenza are at significant risk for morbidity and mortality. MHAA4549A is a human monoclonal immunoglobulin (Ig) G1 antibody that binds to a highly conserved stalk region of the influenza A virus hemagglutinin protein and neutralizes all tested seasonal human influenza A virus strains. Two phase 1 trials examined the safety, tolerability, and pharmacokinetics of MHAA4549A in healthy volunteers. Both single ascending-dose trials were randomized, double blinded, and placebo controlled. Trial 1 randomized 21 healthy adults into four cohorts receiving a single intravenous dose of 1.5, 5, 15, or 45 mg/kg MHAA4549A or placebo. Trial 2 randomized 14 healthy adults into two cohorts receiving a single intravenous fixed dose of 8,400 mg or 10,800 mg of MHAA4549A or placebo. Subjects were followed for 120 days after dosing. No subject was discontinued in either trial, and no serious adverse events were reported. The most common adverse event in both studies was mild headache (trial 1, 4/16 subjects receiving MHAA4549A and 1/5 receiving placebo; trial 2, 4/8 subjects receiving MHAA4549A and 2/6 receiving placebo). MHAA4549A produced no relevant time- or dose-related changes in laboratory values or vital signs compared to those with placebo. No subjects developed an antitherapeutic antibody response following MHAA4549A administration. MHAA4549A showed linear serum pharmacokinetics, with a mean half-life of 22.5 to 23.7 days. MHAA4549A is safe and well tolerated in healthy volunteers up to a single intravenous dose of 10,800 mg and demonstrates linear serum pharmacokinetics consistent with those of a human IgG1 antibody lacking known endogenous targets in humans. (These trials have been registered at ClinicalTrials.gov under registration no. NCT01877785 and NCT02284607).

Ankle and Midfoot Power During Single-Limb Heel Rise in Healthy Adults

2020 ◽  
Vol 36 (1) ◽  
pp. 52-55
Author(s):  
Frank E. DiLiberto ◽  
Deborah A. Nawoczenski
Keyword(s):  
Peak Power ◽  
Force Plate ◽  
Healthy Adults ◽  
Muscle Performance ◽  
Ground Reaction Forces ◽  
Inverse Dynamic ◽  
Heel Height ◽  
Foot Motion ◽  
Reaction Forces ◽  
Ankle Function

Although the midfoot is recognized to have an important role in the successful performance of a single-limb heel rise, healthy heel rise performance remains primarily characterized by ankle function. The purpose of this study was to examine the contribution of midfoot region power to single-limb heel rise in healthy adults. Participants (N = 12) performed 20 single-limb heel rises. An electromagnetic motion capture system and a force plate were used to record 3-segment foot motion and ground reaction forces. Inverse dynamic calculations were performed to obtain ankle and midfoot region powers. These data were evaluated with descriptive statistics. A correlation was performed to evaluate the contribution of midfoot region power to heel height, as heel height is a clinical measure of heel-rise performance. The midfoot contributed power during single-limb heel rise (peak positive power: 0.5 [0.2] W·kg−1). Furthermore, midfoot peak power accounted for 36% of the variance in heel height (P = .04). As energy generating internal mechanisms, such as muscle activity, are attributed to power generation, midfoot tissue loading and muscle performance should be considered during clinical and modeling applications of the heel-rise task.

scholarly journals The Influence of Emotional State on the Masticatory Muscles Function in the Group of Young Healthy Adults

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Stocka Anna ◽  
Kuc Joanna ◽  
Sierpinska Teresa ◽  
Golebiewska Maria ◽  
Wieczorek Aneta
Keyword(s):  
Healthy Volunteers ◽  
Chronic Stress ◽  
Perceived Stress ◽  
Questionnaire Survey ◽  
Emotional State ◽  
Masticatory Muscles ◽  
Healthy Adults ◽  
Mean Values ◽  
Stress Scale ◽  
Masticatory System

Stress may affect the function of all the components of the masticatory system and may ultimately lead to differentiated symptoms and finally to systemic and structural dysfunctions.Objective.To determine the effect of stress on the masticatory muscles function in young healthy adults.Material and Methods. A total of 201 young, Angle’s first class, healthy volunteers, 103 female and 98 male, in the age between 18 and 21 years were recruited into the study. All the participants underwent clinical examination according to the Slavicek scheme, questionnaire survey according to Perceived Stress Scale, and assessment of masticatory muscles function in central occlusion.Results. Symptoms of masticatory system dysfunction were found in the group of 86 subjects (46,24%). All the muscles activity in central occlusion was comparable in female and male groups. Mean values of masseters activities in the group of low stress subjects (75,52 µV ± 15,97) were statistically different from the groups with medium (82,43 µV ± 15,04) and high (81,33 ± 12,05) perceived stressP<0.05.Conclusion. Chronic stress may reveal or exacerbate symptoms of masticatory dysfunction.

Therapeutics

2020 ◽  
pp. 595-621
Keyword(s):  
Regulatory Agency ◽  
Adverse Reactions ◽  
Oral Anticoagulants ◽  
Information Service ◽  
Healthy Adults ◽  
Dental Practice ◽  
Clinical Use ◽  
Osteonecrosis Of The Jaws ◽  
Medicines Information ◽  
Local Contact

This chapter contains a brief guide to the clinical use of some of the more commonly used and useful drugs in hospital and general dental practice. Doses are for healthy adults. There is also information on prescribing guidelines and adverse reactions which may be encountered. The chapter includes local contact details for the Medicines Information Service as well as details on how to report adverse reactions to drugs to the Medicines and Healthcare products Regulatory Agency (MHRA). Contraindications of common drugs are outlined and updated information on oral anticoagulants and antiplatelets is included, as well as details on medication-related osteonecrosis of the jaws.

Sign in / Sign up

Export Citation Format

Share Document