scholarly journals Assessment of Left Ventricle Myocardial Function in Hypertensive Patients Using Three-Dimensional Speckle-Tracking Echocardiography (3D-STE)

2021 ◽  
Vol 11 (4) ◽  
pp. 403-409
Author(s):  
Shima Ali ◽  
Awadia Gareeballah ◽  
Rihab Yousif ◽  
Ahmed Mohammed ◽  
Marwa Mohammed ◽  
...  
Keyword(s):  
Left Ventricle ◽  
Speckle Tracking ◽  
Myocardial Function ◽  
Imaging Modality ◽  
Left Ventricular Diastolic Function ◽  
Left Ventricular ◽  
Control Group ◽  
Speckle Tracking Imaging ◽  
Significant Deterioration ◽  
Hypertensive Patients

Background: Increased myocardial fibrosis in hypertension leads to abnormalities in left ventricular diastolic function. 3D-speckle-tracking imaging (3D-STI) is a primary imaging modality used to detect early changes in the left ventricle (LV). The aim of this study was to assess the left ventricular myocardial function in hypertensive patients using 3D-speckle tracking imaging (3D-STI). Methods and Results: A case control, nonintervention, descriptive study was conducted in the Department of Ultrasound Diagnosis of Union Hospital of Tongji Medical College of Huazhong University of Science and Technology (Wuhan, Hubei, China). The study subjects included 64 patients with hypertension (HT) and, as control group, 44 normotensives. HT patients were divided into HT-I group (SBP of 130-139 mmHg or DBP of 80-89 mmHg, and HT-II group (SBP >140 mmHg or DBP >90 mmHg). In this study, LV geometry and function were assessed using conventional 2D- and 3D-echocardiography in a total of 108 consecutive subjects. LV volumes, global and regional strains were measured using 3D-STI. LV ejection fraction (LVEF) was in normal range in three groups, but in general, it slightly decreased in HT-II patients, compared with control and HT-I groups (62.5±2.1%, 68.0±2.2%, and 67.5±1.3%, respectively, P=0.00). Global systolic strain demonstrated a significant decrease in GLS, GCS, and GRS in the HT-II group, compared with control and HT-I groups. All regional strain parameters (longitudinal, circumferential, and radial) significantly decreased in HT-II patients, compared with control and HT-I groups. Conclusion: A significant deterioration of global LV systolic functions is found in hypertensive patients with well-preserved LVEF, especially in patients with hypertension stage II.

Abstract 14632: Effect of Obesity on Myocardial Strain Determined by Speckle Tracking Imaging

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Meihua Zhu ◽  
Cole Streiff ◽  
Tao He ◽  
Muhammad Ashraf ◽  
Jiahui Zhang ◽  
...  
Keyword(s):  
Speckle Tracking ◽  
Myocardial Dysfunction ◽  
Global Longitudinal Strain ◽  
Myocardial Strain ◽  
Left Ventricular ◽  
Control Group ◽  
Speckle Tracking Imaging ◽  
Initial Weight ◽  
Newborn Mice ◽  
2D Speckle Tracking

Introduction: Obesity may affect cardiac function, which is hard to detect by traditional echocardiography in the early stages. Speckle tracking imaging (STI) is sensitive to subtle myocardial dysfunction. The aim of this study was to determine the influence of obesity on left ventricular (LV) myocardial function in diet-induced obesity (DIO) mice using two-dimensional (2D) speckle tracking echocardiography (STE). Hypothesis: 2D STE is useful to detect obesity-caused myocardial dysfunction. Methods: Twenty newborn mice were divided into two groups: a DIO group (high-fat diet) and a control group (regular-fat diet). 2D image loops were acquired at the end of each month for 6 months. Global longitudinal strain (GLS) and global circumferential strain (GCS) were analyzed at feeding periods over 3 months and 6 months, and compared between the two groups. Results: The control group gained 64% of its initial weight, while the DIO group gained 82% of its initial weight at the 3 month feeding period; and the two groups gained 88% (control) and 125% (DIO) respectively at 6 months. STE analysis revealed an insignificant decrease in strain values in the DIO mice after 3 months; however, after 6 months, the DIO group demonstrated a significant decrease in strain values (P<0.05) despite normal ejection fractions in both groups. Conclusions: 2D STE is highly feasible to detect the myocardial dysfunction caused by obesity in earlier stage. These strain values appear to be related to the severity of obesity.

Role of speckle tracking echocardiography in the assessment of post-repair left ventricular function in patients with late presentation of anomalous origin of the left coronary artery from the pulmonary artery

2014 ◽  
Vol 25 (5) ◽  
pp. 969-975 ◽  
Author(s):  
Gholamhosein Ajami ◽  
Mohammad R. Edraki ◽  
Ali R. Moarref ◽  
Ahmad A. Amirghofran ◽  
Mohammad Borzouee ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Left Ventricle ◽  
Pulmonary Artery ◽  
Speckle Tracking ◽  
Left Coronary Artery ◽  
Speckle Tracking Echocardiography ◽  
Left Ventricular ◽  
Doppler Imaging ◽  
Anomalous Origin ◽  
Control Group

AbstractThe aim of this study was to determine the left ventricular myocardial deformation and segmental myocardial dysfunction by speckle tracking echocardiography and tissue Doppler imaging among the operated patients with anomalous origin of the left coronary artery from the pulmonary artery. The study was conducted on 12 patients diagnosed with anomalous origin of the left coronary artery from the pulmonary artery, who had been operated upon between 2001 and 2013 at the medical centres of Shiraz University of Medical Sciences, Shiraz, Iran. The mean age of the patients at the time of surgical correction was 12.6 years ranging from 6 months to 43 years, and the duration of postoperative follow-up was between 1 and 12 years. Comparison of the strain rate between the patients with acceptable ejection fraction and the control group by tissue Doppler imaging showed significant differences between the two groups regarding the lateral wall (p<0.001), but not the septal wall of the left ventricle (p=0.65). Moreover, the strain values by the speckle tracking method revealed significant differences between the patient and the control group regarding the global strain (p=0.016) and anterior, lateral, and posterior segments of the left ventricle. Although postoperative conventional echocardiography revealed normal global left ventricular function with acceptable ejection fraction, abnormal myocardial deformation of the variable segments of the left ventricle with regional and global myocardial dysfunction were well defined by speckle tracking echocardiography.

scholarly journals Speckle Tracking Imaging Combined With Myocardial Comprehensive Index to Evaluate Left Ventricular Function Changes in Patients With Systemic Lupus Erythematosus

2021 ◽  
Author(s):  
Jia Feng ◽  
zijing Zhai ◽  
zhen Wang ◽  
lei Huang ◽  
shanshan Dong ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Speckle Tracking ◽  
Systolic Function ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
Control Group ◽  
Speckle Tracking Imaging ◽  
Systemic Lupus ◽  
Ventricular Systolic Function ◽  
Comprehensive Index

Abstract ObjectiveTo evaluate left ventricular systolic function in patients with systemic lupus erythematosus (SLE) using three-dimensional speckle tracking imaging (3D-STI). MethodsThirty patients with SLE (SLE group) and 30 healthy people (control group) were examined using 3D-STI, and their clinical characteristics were collected. The following conventional 3D parameters were obtained: left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular ejection fraction (LVEF), spherical index (SPI), left ventricular end-diastolic mass (LV EDmass), and left ventricular end-systolic mass (LV ESmass). The following 3D-STI strain parameters were obtained: global longitudinal strain (GLS), global circumferential strain (GCS), left ventricular twist angle (LVtw), torque (Tor), peak strain dispersion (PSD), and myocardial comprehensive index (MCI). Statistical analysis was used to analyze the differences in the above indicators among the groups and their correlations. ResultsLVEDV and LVEF decreased; LV EDmass and LV ESmass increased; GLS, GCS, LVtw, Tor, and MCI decreased; and PSD increased in the SLE group compared with the control group (P < 0.05). The receiver operating characteristic curve showed that the area under the curve of the MCI was the highest (0.940), the sensitivity of the Tor and MCI was the highest (90.00%), and the specificity of the Tor was the highest (93.33%). Correlation analysis showed that there was a good correlation between the MCI and hs-TropT. ConclusionThe systolic function of the left ventricle is decreased in patients with SLE. 3D-STI technology can detect abnormal left ventricular systolic function in patients with SLE in the early stage.

Abstract 6116: Assessment of Global and Regional Left Ventricular Twist in Patients with Anterior Wall Myocardial Infarction Before and After Revascularization by 2-D Speckle Tracking Imaging

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Mingxing Xie ◽  
Wei Han ◽  
Xinfang Wang ◽  
Minjuan Zheng ◽  
Shuping Ge
Keyword(s):  
Myocardial Infarction ◽  
Speckle Tracking ◽  
Anterior Wall ◽  
Left Ventricular ◽  
Control Group ◽  
Speckle Tracking Imaging ◽  
Time To Peak ◽  
Left Ventricular Twist ◽  
Before And After ◽  
Ventricular Twist

Background: Torsion of the left ventricle is related to myocardial architecture and contractility and is being evaluated as a sensitive marker of cardiac performance. New 2-D speckle tracking imaging (STI) may provide a powerful means of assessing LV torsion noninvasively. This study sought to evaluate the global and regional left ventricular twist in patients with anterior wall myocardial infarction (AMI) before and after revascularization by STI. Methods: A total of 50 subjects, including study group (n = 20) who underwent revascularization for AMI as well as 1 month after revascularization, and control group (n = 30) of normal individuals were studied using STI. LV twist was defined as apical rotation relative to the base. The peak LV twist, standard deviation of time to peak twist (Tw-SD) and maximal temporal difference of time to peak twist (Tw-diff) of 6 myocardial regions were measured. Results: Before revascularization, peak LV twist was significantly reduced while Tw-SD and Tw-diff significantly increased in patients with AMI as compared with normal control group ( P <0.001). One month after revascularization, these changes improved compared with pre- revascularization but remained diminished compared with normal controls (Table 1 ). There were significant correlations between LV peak twist and LVEF ( r =0.78, P <0.05), and LVEDD ( r =−0.63, P <0.05) in all subjects. Conclusion: LV twist measures significantly diminished and dys-synchronized in AMI patients prior to revascularization and improved after revascularization. STI measures correlate with EF and have the potential to quantify left ventricular global and segmental dysfunction in patients with AMI. Left ventricular regional and global peak twist, torsion and synchrony measures

Clinical significance of myocardial strain in the patients with chd (literature review)

10.12737/7363 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 0-0
Author(s):  
Туаева ◽  
Z. Tuaeva ◽  
Кириченко ◽  
T. Kirichenko
Keyword(s):  
Left Ventricle ◽  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Contractile Function ◽  
Imaging Modality ◽  
Myocardial Strain ◽  
Left Ventricular ◽  
Lv Function ◽  
Left Ventricular Myocardium ◽  
Wide Range

2-D echocardiography is currently the first-line imaging modality for assessing global and regional function of left ventricle (LV). Using 2-D echocardiography, LV function is most often evaluated visually, as a result of the quality of the research depends directly on the experience and qualifications of the expert. The new technology of two-dimensional speckle tracking echocardiography allows to assessing the contractile function of the left ventricle quantitative. Over the years, the numerous studies have demonstrated the value of speckle tracking echocardiography in the diagnosis and risk stratification of a wide range of cardiac diseases, including coronary heart disease [14]. During the cardiac cycle the speckle tracking echocardiography allows in semi-automatic mode to evaluate the deformation of the myocardium in the three spatial directions: longitudinal, radial, and circular. In addition, speckle tracking estimates the direction of rotation and speed of motion of the left ventricular myocardium. This technology may have important clinical value for quick and accurate assessment of global and segmental myocardial function. The use of estimates of the deformation of the myocardium and the speed of deformation of the myocardium by means of speckle tracking method may be able to increase the sensitivity and precision of stenosing lesions of the coronary arteries [16].

scholarly journals Cardioprotective effect of Trimetazidine in patients with early breast cancer receiving anthracycline-based chemotherapy

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M.G Delle Donne ◽  
A Iannielli ◽  
P Capozza ◽  
R De Caterina ◽  
M Marzilli
Keyword(s):  
Breast Cancer ◽  
Diastolic Dysfunction ◽  
Speckle Tracking ◽  
Tissue Doppler ◽  
Left Ventricular ◽  
Cardiac Biomarkers ◽  
Doppler Imaging ◽  
Control Group ◽  
Speckle Tracking Imaging ◽  
Lv Diastolic Dysfunction

Abstract Background Anthracyclines, alone or in combination with other drugs, are among the most effective chemotherapeutic agents to treat breast cancer both in the adjuvant and neoadjuvant settings. Unfortunately, anthracycline-associated dose-dependent cardiotoxicity is a limiting factor in clinical use. Extensive efforts have been devoted to identifying strategies to prevent anthracycline-induced cardiotoxicity. However, most cardioprotective agents have shown little efficacy in clinical trials. We hypothesized that myocardial damage by anthracyclines could be rationally prevented by using trimetazidine (TMZ), previously reported to interfere with anthracycline- and trastuzumab-induced cardiotoxicity. Therefore, we planned a randomized, controlled, open trial to determine whether TMZ may prevent the development of left ventricular (LV) dysfunction in patients receiving standard treatment for breast cancer. Methods The trial included 73 patients (41.2±8.1 years) undergoing surgery for breast cancer, who were scheduled for adjuvant epirubicin-containing chemotherapy and, if indicated, trastuzumab. Patients were randomly allocated in a 1:1 ratio to receive TMZ or baseline therapy only (control group). The main study endpoint was a reduction in the deterioration of left ventricular ejection fraction (LVEF), as evaluated by serial echocardiography performed at randomization and then every 3 months after the start of chemotherapy and for 1 year after its completion. Secondary outcome measures included echocardiographic indices of LV diastolic dysfunction, structural myocardial alterations, as assessed by speckle tracking echocardiography, and changes in cardiac biomarkers (troponin and brain natriuretic peptide). Results We found no significant differences between the two groups regarding baseline clinical and echocardiographic parameters. The two groups reached a similar cumulative dose of doxorubicin. No patient died during the study and no patients withdrew from chemotherapy. Three months after the start of chemotherapy, nonsignificant changes were observed in LVEF, shortening fraction, and LV diameters. No significant changes in cardiac biomarkers were observed in either group. Tissue Doppler imaging detected a significant decrease in myocardial velocities (P=0.001) in the control group, indicating LV diastolic dysfunction. In the same group, speckle tracking imaging revealed a statistically significant alteration in ventricular deformation (P=0.01), which means a decrease in LV systolic function. In the TMZ group, no significant alterations in LV diastolic function were observed. Conclusions Tissue Doppler imaging and speckle tracking imaging are more sensitive than conventional echocardiograms in the early diagnosis of cardiac dysfunction and TMZ seems to have an important role in the prevention of cardiotoxicity. Funding Acknowledgement Type of funding source: None

scholarly journals Speckle tracking imaging combined with myocardial comprehensive index to evaluate left ventricular function changes in patients with systemic lupus erythematosus

2021 ◽  
Author(s):  
Jia Feng ◽  
Zijing Zhai ◽  
Zhen Wang ◽  
Lei Huang ◽  
Shanshan Dong ◽  
...  
Keyword(s):  
Lupus Erythematosus ◽  
Speckle Tracking ◽  
Systolic Function ◽  
Left Ventricular Systolic Function ◽  
Left Ventricular ◽  
Control Group ◽  
Speckle Tracking Imaging ◽  
Systemic Lupus ◽  
Ventricular Systolic Function ◽  
Severe Group

Objective: To evaluate early changes in left ventricular systolic function in patients with systemic lupus erythematosus (SLE) using three-dimensional speckle tracking imaging (3D-STI). Methods: Thirty SLE patients and 30 healthy people (control group) were selected, the patients were further divided into subgroups according to their Safety of Estrogens in Lupus Erythematosus National Assessment version of the SLE Disease Activity Index (SELENA-SLEDAI) score: SELENA-SLEDAI ≤ 12 (mild-to-moderate group), SELENA-SLEDAI > 12 (severe group). Blood samples were obtained from patients and laboratory investigations were performed. All participants were examined using 3D-STI, the 3D conventional and strain parameters were obtained. The above parameters were compared in the three studied groups. Receiver operating curves (ROC) were prepared for above parameters and analyzed to identify correlations among LVEF, GLS, GCS, LVtw, Tor, MCI and hs-TropT. Results: Compared with the control group, the absolute values of LVEDV, LVEF, GLS, GCS, LVtw, Tor and MCI decreased, LV EDmass, LV ESmass and PSD increased in the mild-to-moderate and the severe groups (P2 < 0.05, P3 < 0.05). There was statistically significant difference in terms of strain parameters between the mild-to-moderate group and the severe group (P1 < 0.05). The highest area under the ROC for MCI was 0.909, the highest sensitivity for MCI was 90.00%, and the highest specificity for Tor was 86.67%. Correlation analysis showed that there was a good correlation between the MCI and hs-TropT (r = − 0.677). Conclusion: 3D-STI technology may help detect early changes in left ventricular systolic function in patients with SLE

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