Preoperative CT versus Intraoperative Hybrid DynaCT Imaging for Localization of Small Pulmonary Nodules: A Randomized Controlled Trial
Abstract Background Small and/or deep pulmonary nodules have been traditionally localized using preoperative CT (POCT) imaging. However, the advent of hybrid operating rooms (ORs) has allowed intraoperative computed tomography (IOCT)-guided lesion localization. This single center, open-label, randomized, controlled clinical trial aims to compare the efficacy and safety of IOCT versus POCT. Methods/design The study sample will consist of patients presenting with small and/or deep pulmonary nodules who will be randomly allocated to either POCT or IOCT. The time required for identifying the lesion will be the primary efficacy outcome. The following parameters will serve as secondary endpoints: rate of successful targeting in the operating field, time at risk, complication (pneumothorax and hemorrhage) rates, and radiation exposure. Discussion Owing to the increased availability of HORs, our data will be crucial to clarify the feasibility and safety of IOCT versus the traditional POCT approach.