Effectiveness of probiotics for antipsychotic-induced functional bowel disorders: A single-center retrospective observational study

Mapping Intimacies ◽

10.21203/rs.2.18286/v1 ◽

2019 ◽

Author(s):

Masaru Nakamura ◽

Takahiko Nagamine

Keyword(s):

Observational Study ◽

Bowel Movement ◽

Functional Constipation ◽

Antipsychotic Treatment ◽

Intestinal Function ◽

Single Center ◽

Functional Bowel Disorders ◽

Psychiatric Setting ◽

Stool Form ◽

Bowel Disorders

Abstract Background Probiotics have the potential to improve functional constipation, however, evidence is lacking regarding its recommendation related to gut microbiota. Constipation is highly prevalent and a serious side-effect in antipsychotic treatment. This study was to investigate the effects of probiotics supplementation on defecation in psychiatry.Methods Subjects consisted of 31 male and 37 female inpatients who were co-administrated either of two probiotics: BIO-THREE or BIOFERMIN tablets. The medications that affect bowel movement including gastrointestinal drugs and antipsychotics in addition to their levels of chlorpromazine equivalent (CPeq) doses were compared between the two groups. Intestinal function was evaluated at baseline and one and two months using Bristol stool form scale. Sequential change of the three indices: average, constipation and diarrhea levels were compared within the group and analyzed to see any significant correlation against the CPeq levels. Results There were no significant differences in the medical treatment between the groups. In both groups, the average and constipation levels increased, and the diarrhea levels decreased at two months from baseline; in particular, the constipation levels were significantly increased at two months from baseline in the BIO-THREE group (-9.6±1.0 vs -6.5±0.9, mean±se). In the BIO-THREE group, only the diarrhea levels were significantly negatively correlated with the CPeq levels at two months (r= -0.341), while no such correlations were found in the BIOFERMIN group.Conclusions Probiotics supplementation may improve stool consistency, especially severe constipation and ameliorate diarrhea depended on antipsychotic dosage in psychiatric setting.

Download Full-text

Multicenter observational study on functional bowel disorders diagnosed using Rome III diagnostic criteria in Japan

Journal of Gastroenterology ◽

10.1007/s00535-017-1428-9 ◽

2018 ◽

Vol 53 (8) ◽

pp. 916-923 ◽

Cited By ~ 1

Author(s):

Masayoshi Ono ◽

Mototsugu Kato ◽

Shuichi Miyamoto ◽

Momoko Tsuda ◽

Takeshi Mizushima ◽

...

Keyword(s):

Observational Study ◽

Diagnostic Criteria ◽

Functional Bowel Disorders ◽

Multicenter Observational Study ◽

Rome Iii ◽

Bowel Disorders

Download Full-text

Clinical, Physiological, and Psychological Correlates of the Improvement of Defecation during Menses in Women with Functional Gastrointestinal Disorders

Visceral Medicine ◽

10.1159/000504184 ◽

2020 ◽

Vol 36 (6) ◽

pp. 487-493

Author(s):

Michel Bouchoucha ◽

Ghislain Devroede ◽

Pierre Rompteaux ◽

Florence Mary ◽

Bakhtiar Bejou ◽

...

Keyword(s):

Transit Time ◽

Functional Gastrointestinal Disorders ◽

Selection Procedure ◽

Functional Constipation ◽

Colonic Transit ◽

Psychiatric Disease ◽

Functional Bowel Disorders ◽

Psychological Correlates ◽

Bowel Disorders ◽

Physiological Tests

Background/Aims: Little is known about the improvement in defecation frequently reported by women around menses. We aimed to describe clinical, physiological, and psychological correlates of this improvement in those with functional bowel disorders. Patients and Methods: We recruited 478 consecutive premenopausal adult females with no indication of gynecologic or psychiatric disease, who were attending an outpatient functional bowel disorders clinic. Patients completed a Rome III questionnaire, psychological evaluation stool form, and a 10-point Likert scale for constipation, diarrhea, bloating, and abdominal pain. These patients underwent physiological tests, anorectal manometry, and colonic transit time and were classified according to the presence or the absence of improvement in defecation during menses. The reverse selection procedure was used for model selection during multivariate logistic regression where statistically significant variables (p < 0.01) remained in the adjusted model. Results: Ninety-seven patients (20%) reported easier defecation during menstruation. These patients were younger (p < 0.001) but had similar body mass indices and psychological profiles as the other patients. Clinically, they only reported more frequent irritable bowel syndrome (IBS) with constipation (p = 0.007), with harder stools (p = 0.005) and delayed left colon transit time (p = 0.002). No anorectal manometric parameter was different between the 2 groups. Conclusion: Improvement of constipation during menses is mainly associated with younger age and constipation-IBS phenotype and not with functional constipation.

Download Full-text

Chapter 7: Functional Bowel Disorders: Irritable Bowel Syndrome and Functional Constipation

Rome IV Functional Gastrointestinal Disorders ◽

10.24890/pc.07 ◽

2017 ◽

Keyword(s):

Irritable Bowel Syndrome ◽

Functional Constipation ◽

Functional Bowel Disorders ◽

Bowel Disorders ◽

Irritable Bowel

Download Full-text

Data Mining Approach for the Characterization of Functional Bowel Disorders According to Symptom Intensity Provides a Small Number of Homogenous Groups

Digestive Diseases ◽

10.1159/000504435 ◽

2019 ◽

Vol 38 (4) ◽

pp. 310-319 ◽

Cited By ~ 3

Author(s):

Michel Bouchoucha ◽

Ghislain Devroede ◽

Marinos Fysekidis ◽

Pierre Rompteaux ◽

Jean-Marc Sabate ◽

...

Keyword(s):

Classification Tree ◽

A Priori ◽

Functional Constipation ◽

Gaussian Mixture ◽

Functional Bowel Disorders ◽

Homogeneous Groups ◽

Mild Pain ◽

Symptom Intensity ◽

Rome Iii ◽

Bowel Disorders

Background/Aims: The aim of the present study is to evaluate if the intensity of the cardinal symptoms of functional bowel disorders could be used to identify homogenous groups of patients defined by the Rome criteria. Method: In this observational study, 1,729 consecutive outpatients (73% females) filled out the Rome III questionnaire and 10-point Likert scales for constipation, diarrhea, bloating (BL)/distension, abdominal pain (AP) during the week before the medical consultation. A Gaussian mixture model was used for clustering the patients according to the intensity of symptoms without a priori information, and a classification tree was constructed from this clustering. Data were analyzed using analysis of variance and logistic regression analysis. Results: According to the intensity of symptoms, the patients are divided into 8 groups named according to their main symptomatology: “painful constipation” (PFC), “mild pain constipation” (MPC), “painful diarrhea” (PFD), “mild pain diarrhea” (MPD), “mixed transit” (MT), “BL,” “AP,” and “nonspecific” (NS). The study of the relationship between the Rome III classification and this new grouping shows that irritable bowel syndrome (IBS)-constipation is associated with PFC, IBS-diarrhea with PFD and MPD, SII-mixed with MT, SII-unspecified with BL, functional constipation with PFC and MPC, functional diarrhea with MPD and NS, BL with “BL” and NS, nonspecific functional bowel disorders (FBD) with NS, and functional AP with “BL” and AP (p < 0.01 for all associations). Conclusion: A symptom intensity-based classification of FBD patients could simplify clinical phenotype, give homogeneous groups of patients, and could eventually be used by nongastroenterologists and in clinical research.

Download Full-text