Association of PIN3 16-bp Duplication Polymorphism of TP53 with Breast Cancer Risk in Mali and A Meta-analysis.

Abstract Background. Breast cancer, the most common tumor in women in Mali and worldwide has been linked to several risk factors, including genetic factors, such as the PIN3 16-bp duplication polymorphism of TP53. The aim of our study was to evaluate the role of the PIN3 16-bp duplication polymorphism in the susceptibility to breast cancer in the Malian population and to perform a meta-analysis to better understand the correlation with data from other populations.Methods. We analyzed the PIN3 16-bp duplication polymorphism in blood samples of 60 Malian women with breast cancer and 60 healthy Malian women using PCR. In addition, we performed a meta-analysis of case-control study data from international databases, including Pubmed, Harvard University Library, Genetics Medical Literature Database, Genesis Library and Web of Science. Overall, odds ratio (OR) with 95% CI from fixed and random effects models were determined. Inconsistency was used to assess heterogeneity between studies and publication bias was estimated using the funnel plot.Results. In the studied Malian patients, a significant association of PIN3 16-bp duplication polymorphism with breast cancer risk was observed in dominant (A1A2+A2A2 vs. A1A1: OR = 2.26, CI 95% = 1.08-4.73; P = 0.02) and additive (A2 vs. A1: OR =1.87, CI 95% = 1.05-3.33; P = 0.03) models, but not in the recessive model (P = 0.38). In the meta-analysis, nineteen (19) articles were included with a total of 6,018 disease cases and 4,456 controls. Except for the dominant model (P = 0.15), an increased risk of breast cancer was detected with the recessive (OR=1.46, 95% CI = 1.15-1.85; P = 0.002) and additive (OR = 1.11, 95% CI = 1.02-1.19; P = 0.01) models.Conclusion. The case-control study showed that PIN3 16-bp duplication polymorphism of TP53 is a significant risk factor for breast cancer in Malian women. These findings are supported by data from the meta-analysis carried out on different ethnic groups around the world.

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The SLC4A7 variant rs4973768 is associated with breast cancer risk: evidence from a case–control study and a meta-analysis

Breast Cancer Research and Treatment ◽

10.1007/s10549-012-2309-9 ◽

2012 ◽

Vol 136 (3) ◽

pp. 847-857 ◽

Cited By ~ 32

Author(s):

Wei Chen ◽

Rong Zhong ◽

Jie Ming ◽

Li Zou ◽

Beibei Zhu ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Case Control Study ◽

Meta Analysis ◽

Case Control ◽

Control Study

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AA genotype of cyclin D1 G870A polymorphism increases breast cancer risk: Findings of a case‐control study and meta‐analysis

Journal of Cellular Biochemistry ◽

10.1002/jcb.28800 ◽

2019 ◽

Vol 120 (10) ◽

pp. 16452-16466 ◽

Cited By ~ 1

Author(s):

Naseem Akhter ◽

Faisal Abdulrahman Alzahrani ◽

Sajad Ahmad Dar ◽

Mohd Wahid ◽

Real Sumayya Abdul Sattar ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Cyclin D1 ◽

Case Control Study ◽

Meta Analysis ◽

Case Control ◽

Control Study

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A higher Dietary Inflammatory Index score is associated with a higher risk of breast cancer among Chinese women: a case–control study

British Journal Of Nutrition ◽

10.1017/s0007114517001192 ◽

2017 ◽

Vol 117 (10) ◽

pp. 1358-1367 ◽

Cited By ~ 19

Author(s):

Wu-Qing Huang ◽

Xiong-Fei Mo ◽

Yan-Bin Ye ◽

Nitin Shivappa ◽

Fang-Yu Lin ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Case Control Study ◽

Chinese Women ◽

Case Control ◽

Dietary Inflammatory Index ◽

Inflammatory Index ◽

Increased Risk ◽

Control Study

AbstractPrevious studies have investigated the association between dietary inflammatory potential and the development of cancer. For breast cancer the results have been equivocal. The present study aimed to investigate whether higher Dietary Inflammatory IndexTM (DII) scores were associated with increased risk of breast cancer among Chinese women. A total of 867 cases and 824 controls were recruited into the present case–control study from September 2011 to February 2016. DII scores were computed based on baseline dietary intake assessed by a validated 81-item FFQ. The OR and 95 % CI were assessed by multivariable logistic regression after adjusting for various potential confounders. DII scores in this study ranged from −5·87 (most anti-inflammatory score) to +5·71 (most proinflammatory score). A higher DII score was associated with a higher breast cancer risk (adjusted ORquartile 4 v. 1 2·28; 95 % CI 1·71, 3·03; adjusted ORcontinuous 1·40; 95 %CI 1·25, 1·39). In stratified analyses, positive associations also were observed except for underweight women or women with either oestrogen receptor+ or progesterone receptor+ status (but not both). Results from this study indicated that higher DII scores, corresponding to more proinflammatory diets, were positively associated with breast cancer risk among Chinese women.

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Methylenetetrahydrofolate reductase (MTHFR) and breast cancer risk: a nested-case-control study and a pooled meta-analysis

Breast Cancer Research and Treatment ◽

10.1007/s10549-006-9491-6 ◽

2007 ◽

Vol 106 (2) ◽

pp. 263-271 ◽

Cited By ~ 44

Author(s):

Debora Macis ◽

Patrick Maisonneuve ◽

Harriet Johansson ◽

Bernardo Bonanni ◽

Edoardo Botteri ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Methylenetetrahydrofolate Reductase ◽

Case Control Study ◽

Meta Analysis ◽

Case Control ◽

Nested Case Control ◽

Control Study

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Methylation of WT1, CA10 in peripheral blood leukocyte is associated with breast cancer risk: a case-control study

10.21203/rs.3.rs-27678/v2 ◽

2020 ◽

Author(s):

Anqi Ge ◽

Song Gao ◽

Yupeng Liu ◽

Hui Zhang ◽

Xuan Wang ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Case Control Study ◽

Case Control ◽

Elevated Risk ◽

Luminal B ◽

Increased Risk ◽

Risk Of Cancer ◽

Control Study

Abstract Background: Studies have shown that abnormal changes of specific-gene DNA methylation in leukocytes may be associated with an elevated risk of cancer. However, associations between the methylation of the zinc-related genes, WT1 and CA10, and breast cancer risk remain unknown. Methods: The methylation of WT1 and CA10 was analyzed by methylation-sensitive high-resolution-melting (MS-HRM) in a case-control study with female subjects (N=959). Logistic regression was used to analyze the associations, and propensity score (PS) method was used to adjust confounders. Results: The results showed that WT1 hypermethylation was associated with an increased risk of breast cancer, with an odds ratio (OR) of 3.07 [95% confidence interval (CI): 1.67-5.64, P<0.01]. Subgroup analyses showed that WT1 hypermethylation was specifically associated with an elevated risk of luminal A subtype (OR=2.62, 95% CI: 1.11-6.20, P=0.03) and luminal B subtype (OR=3.23, 95% CI: 1.34-7.80, P=0.01). CA10 hypermethylation was associated with an increased risk of luminal B subtype (OR=1.80, 95% CI: 1.09-2.98, P=0.02). Conclusion: The results of the present study suggest that the hypermethylation of WT1 methylation in leukocytes is significantly associated with an increased risk of breast cancer. The hypermethylation of WT1 is associated with an increased risk of luminal subtypes of breast cancer, and the hypermethylation of CA10 is associated with an increased risk of luminal B subtype of breast cancer.

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