scholarly journals MicroRNAs as potential biomarkers for the diagnosis of traumatic brain injury: a systematic review and meta-analysis

2019 ◽  
Author(s):  
Qian Zhou ◽  
Jian Yin ◽  
Yadong Wang ◽  
Xinsuo Zhuang ◽  
Zhiyang He ◽  
...  
Keyword(s):  
Systematic Review ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Diagnostic Accuracy ◽  
Brain Tissue ◽  
Meta Analysis ◽  
Area Under The Curve ◽  
Clinical Value ◽  
Mirnas Expression ◽  
Potential Biomarkers

Abstract Background: Traumatic brain injury (TBI) is a sudden trauma on the head, commonly associated with death and long-term disability. MicroRNAs (miRNAs) are potential biomarkers of diverse diseases, including TBI. However, few systematic reviews and meta-analyses have been conducted to determine the clinical value of miRNAs expression in TBI patients.Methods: We did a comprehensive literature search to identify articles that have reported on the diagnostic and prognostic value of miRNAs expression in TBI patients.Results: Six studies investating the diagnostic value of miRNA in TBI were analyzed in this study. The overall sensitivity, specificity and area under the curve (AUC) of miRNAs in diagnosis of TBI were 92% [95% confidence interval (CI): 0.87–0.95]; 92% (95% CI 0.78–0.97) and 96% (95% CI 0.94–0.97), respectively. We found that panels of multiple miRNAs could improve the diagnostic accuracy of TBI. Compared to saliva, detected samples like blood and brain tissue could significantly enhance diagnostic accuracy. Besides, the AUC of miRNAs in severe TBI was 0.97, with 92% sensitivity and 92% specificity.Conclusions: This systematic review and meta-analysis demonstrated that miRNAs could be potential diagnostic markers in TBI patients. MiRNAs detected in blood and brain tissue display high accuracy for TBI diagnosis.

scholarly journals MicroRNAs as potential biomarkers for the diagnosis of Traumatic Brain Injury: A systematic review and meta-analysis

2021 ◽  
Vol 18 (1) ◽  
pp. 128-136
Author(s):  
Qian Zhou ◽  
Jian Yin ◽  
Yadong Wang ◽  
Xinsuo Zhuang ◽  
Zhiyang He ◽  
...  
Keyword(s):  
Systematic Review ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Meta Analysis ◽  
Potential Biomarkers

scholarly journals A Systematic Review and Meta-Analysis on Effect of Beta-Blockers in Severe Traumatic Brain Injury

2021 ◽  
pp. 1-7
Author(s):  
William A. Florez-Perdomo ◽  
Edgar Felipe Laiseca Torres ◽  
Sergio a Serrato ◽  
Tariq Janjua ◽  
Andrei F. Joaquim ◽  
...  
Keyword(s):  
Systematic Review ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Severe Traumatic Brain Injury ◽  
Beta Blockers ◽  
Meta Analysis

The Prognostic Significance of Biomarkers in Cerebrospinal Fluid Following Severe Traumatic Brain Injury: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Victor Schwartz Hvingelby ◽  
Carsten Bjarkam ◽  
Frantz Rom Poulsen ◽  
Tiit Illimar Mathiesen ◽  
Morten Thingemann Bøtker ◽  
...  
Keyword(s):  
Systematic Review ◽  
Traumatic Brain Injury ◽  
Cerebrospinal Fluid ◽  
Brain Injury ◽  
Severe Traumatic Brain Injury ◽  
Meta Analysis ◽  
Prognostic Significance

scholarly journals Diagnostic and prognostic value of miRNAs in hepatoblastoma: A systematic review with meta-analysis

2021 ◽  
Author(s):  
Bin Wu ◽  
◽  
Lixia Guo ◽  
Kaikai Zhen ◽  
Chao Sun
Keyword(s):  
Systematic Review ◽  
Prognostic Value ◽  
Meta Analysis ◽  
Area Under The Curve ◽  
Prognostic Indicator ◽  
Diagnostic Odds Ratio ◽  
Diagnostic Value ◽  
Likelihood Ratios ◽  
Clinical Value ◽  
Diagnostic And Prognostic Value

Review question / Objective: Background and aim: Increasing evidence has revealed the valuable diagnostic and prognostic applications of dysregulated microRNAs (miRNAs) in hepatoblastoma (HB), the most common hepatic malignancy during childhood. However, these results are inconsistent and remain to be elucidated. In the present study, we aimed to systematically compile up-to-date information regarding the clinical value of miRNAs in HB. Methods: Articles concerning the diagnostic and prognostic value of single miRNAs for HB were searched from databases. The sensitivity (SEN), specificity (SPE), positive and negative likelihood ratios (PLR and NLR), diagnostic odds ratio (DOR), area under the curve (AUC), and hazard ratios (HRs) were separately pooled to explore the diagnostic and prognostic performance of miRNA. Subgroup and meta-regression analyses were further carried out only in the event of heterogeneity. Results: In all, 20 studies, involving 264 HB patients and 206 healthy individuals, met the inclusion criteria in the six included literature articles. For the diagnostic analysis of miRNAs in HB, the pooled SEN and SPE were 0.76 (95% CI: 0.72–0.80) and 0.75 (95% CI: 0.70–0.80), respectively. Moreover, the pooled PLR was 2.79 (95% CI: 2.12–3.66), NLR was 0.34 (95% CI: 0.26–0.45), DOR was 10.24 (95% CI: 6.55–16.00), and AUC was 0.83, indicating that miRNAs had moderate diagnostic value in HB. For the prognostic analysis of miRNAs in HB, the abnormal expressions of miR-21, miR-34a, miR-34b, miR-34c, miR-492, miR-193, miR-222, and miR-224 in patients were confirmed to be associated with a worse prognosis. The pooled HR was 1.74 (95% CI: 1.20–2.29) for overall survival (OS) and 1.74 (95% CI: 1.31–2.18) for event-free survival (EFS), suggesting its potential as a prognostic indicator for HB. Conclusion: To the best of our knowledge, this is the first comprehensive systematic review and meta-analysis that examines the diagnostic and prognostic role of dysregulated miRNAs in HB patients. The combined meta-analysis results supported the previous individual finds that miRNAs might provide a new, noninvasive method for the diagnostic and prognostic analyses ofHB.

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