Cannabis sativa terpenes are cannabimimetic and selectively enhance cannabinoid activity

Limited evidence has suggested that terpenes found in Cannabis sativa are analgesic, and could produce an “entourage effect” whereby they modulate cannabinoids to result in improved outcomes. However this hypothesis is controversial, with limited evidence. We thus investigated Cannabis sativa terpenes alone and with the cannabinoid agonist WIN55,212 using in vitro and in vivo approaches. We found that the terpenes α-humulene, geraniol, linalool, and β-pinene produced cannabinoid tetrad behaviors in mice, suggesting cannabimimetic activity. Some behaviors could be blocked by cannabinoid or adenosine receptor antagonists, suggesting a mixed mechanism of action. These behavioral effects were selectively additive with WIN55,212, suggesting terpenes can boost cannabinoid activity. In vitro experiments showed that all terpenes activated the CB1R, while some activated other targets. Our findings suggest that these Cannabis terpenes are multifunctional cannabimimetic ligands that provide conceptual support for the entourage effect hypothesis and could be used to enhance the therapeutic properties of cannabinoids.

Designed Synthesis of Diversely Substituted Hydantoins and Hydantoin-Based Hybrid Molecules: A Personal Account

Hydantoin and its analogs such as thiohydantoin and iminohydantoin have received substantial attention both from a chemical and biological point of view. Several compounds of this class have shown useful pharmacological activities such as anticonvulsant, antitumor, antiarrhythmic, herbicidal, and others that lead in some cases to clinical applications. Because of broad-spectrum activities, intensive research efforts have been dedicated in industry and academia to the synthesis and structural modifications of hydantoin and its derivatives. Realizing the importance of hydantoin in organic and medicinal chemistry, we also initiated a research program to successfully design and develop the new routes/methods resulting in the formation of hydantoin, thiohydantoin, and iminohydantoin substituted at different positions particularly at the N-1 position without following protection-deprotection strategy. Given the fact that the combination of two or more pharmacophoric groups may lead to hybrid molecules which result in a mixed mechanism of action on the biological target. We, therefore, further extended the developed strategy for the synthesis of new types of hydantoin-based hybrid molecules by combining hydantoin with a triazole, isoxazoline, and phosphate scaffolds as another pharmacophoric group to exploit diverse biological functions.

Effect of Stress on Creep Behavior of Single Crystal Alloy IC6SX at 980°C

Ni3Al-based single crystal alloy IC6SX was prepared by seed crystal method. The effect of different stress conditions on creep behavior of this alloy at 980°C was investigated. The results showed that the creep life of this alloy at 980°C decreased significantly with the increase of stress. When the stress increased from 180 MPa to 230 MPa, the creep life dropped from 245.5 h to 69.3 h, and the steady-state creep rate increased slightly but not significantly. Meanwhile, the morphology of γ ′ phase and dislocation after creep were studied. The results showed that with the increase of stress, the density of dislocations in the γ ′ phase increased gradually, the strength of this alloy decreased gradually, so the creep life decreased significantly. The Y-NiMo phase resolved from the γ phase decreased gradually as the creep life decreased. The creep experiment of the alloy was carried out at 980°C. Due to the higher temperature, the diffusion of atoms in this alloy became faster. Deformation was not only caused by the slippage of dislocations in the crystal but also by the diffusion of atoms. Therefore, the creep mechanism of single crystal alloy IC6SX at this temperature is a mixed mechanism of dislocation glide and diffusion.

Cannabis sativa Terpenes are Cannabimimetic and Provide Support for the Entourage Effect Hypothesis

Limited evidence has suggested that terpenes found in Cannabis sativa are analgesic, and could produce an “entourage effect” whereby they modulate cannabinoids to result in improved outcomes. However this hypothesis is controversial, with limited evidence. We thus investigated Cannabis sativa terpenes alone and with the cannabinoid agonist WIN55,212 using in vitro and in vivo approaches. We found that the terpenes α-humulene, geraniol, linalool, and β-pinene produced cannabinoid tetrad behaviors in mice, suggesting cannabimimetic activity. Some behaviors could be blocked by cannabinoid or adenosine receptor antagonists, suggesting a mixed mechanism of action. These behavioral effects were additive with WIN55,212, providing support for a terpene “entourage effect.” In vitro experiments showed that all terpenes activated the CB1R, while some activated other targets. Our findings suggest that these Cannabis terpenes are multifunctional cannabimimetic ligands that provide support for the entourage effect hypothesis and could be used to enhance the therapeutic properties of cannabinoids.

A privacy protection solution based on NLPCA for blockchain supply chain financial system

Many supply chain finance problems can be fundamentally solved by using blockchain. The current technical challenge of applying blockchain in supply chain finance is the lack of systematic privacy protection architecture. Based on the architecture of Julongchain, through the nonlinear principal component analysis in private data feature extraction, this paper proposed a new type of privacy protection architecture based on specific supply chain financial system. This privacy protection solution split privacy data by decision machine, then mixed data using mixed mechanism, finally determined the characteristic weight of privacy data by applying the decentralized decision institution.